Cell death in the oligodendrocyte lineage: a molecular perspective of life/death decisions in development and disease.

abstract：:In the peripheral nervous system, Schwann cells make myelin, a specialized sheath that is essential for rapid axonal conduction of action potentials. Immature Schwann cells initially interact with many axons, but, through a process termed radial sorting, eventually interact with one segment of a single axon as promyel...

journal_title：Glia

authors： Raphael AR,Lyons DA,Talbot WS

更新日期：2011-07-01 00:00:00

abstract：:The poor regenerative ability of neurons of the central nervous system in mammals, as compared with their counterpart in fish or amphibians, is thought to stem from differences in their immediate nonneuronal environment and its response to axonal injury. We describe one aspect of the environmental response to axonal i...

journal_title：Glia

authors： Cohen I,Sivron T,Lavie V,Blaugrund E,Schwartz M

更新日期：1994-01-01 00:00:00

abstract：:The possible consequences of activating bradykinin (Bk) receptors on identified astrocyte subtypes derived from rat cortex have been investigated in terms of: 1) mobilization of intracellular Ca2+; and 2) electrophysiological response. Bk induced a rapid, transient rise in intracellular Ca2+ in 63% of cortical type-1-...

journal_title：Glia

authors： Stephens GJ,Cholewinski AJ,Wilkin GP,Djamgoz MB

更新日期：1993-12-01 00:00:00

abstract：:Galactosylceramide (GalC) is the major sphingolipid of the myelin membrane. Mice lacking GalC due to ceramide galactosyltransferase (CGT) deficiency form unstable and functionally affected myelin and exhibit a progressive demyelination, accompanied by severe motor coordination deficits. In addition to oligodendrocytes...

journal_title：Glia

authors： Zöller I,Büssow H,Gieselmann V,Eckhardt M

更新日期：2005-11-15 00:00:00

abstract：:The biologically active lipid metabolite, platelet-activating factor (PAF), is thought to contribute to inflammatory processes and tissue damage in a variety of central nervous system (CNS) injuries. In previous studies, we found that after contusion spinal cord injury, treatment with a PAF antagonist led to significa...

journal_title：Glia

authors： Hostettler ME,Knapp PE,Carlson SL

更新日期：2002-05-01 00:00:00

abstract：:The substantia nigra pars reticulata (SNr) is a major output nucleus of the basal ganglia circuitry particularly sensitive to pathological dopamine depletion. Indeed, hyperactivity of SNr neurons is known to be responsible for some motor disorders characteristic of Parkinson's disease. The neuronal processing of basal...

journal_title：Glia

authors： Bosson A,Boisseau S,Buisson A,Savasta M,Albrieux M

更新日期：2015-04-01 00:00:00

abstract：:Neurogenesis persists in the adult subventricular zone (SVZ) of the mammalian brain. During aging, the SVZ neurogenic capacity undergoes a progressive decline, which is attributed to a decrease in the population of neural stem cells (NSCs). However, the behavior of the NSCs that remain in the aged brain is not fully u...

journal_title：Glia

authors： Capilla-Gonzalez V,Cebrian-Silla A,Guerrero-Cazares H,Garcia-Verdugo JM,Quiñones-Hinojosa A

更新日期：2014-05-01 00:00:00

abstract：:Synaptic zinc ions released during synaptic transmission interact with pre- and postsynaptic neuroreceptors, thus modulating neurotransmission. It is likely that they have to be efficiently cleared from the extracellular milieu to assure subsequent synaptic events. Both neurons and glia are assumed to participate in t...

journal_title：Glia

authors： Varea E,Alonso-Llosà G,Molowny A,Lopez-Garcia C,Ponsoda X

更新日期：2006-09-01 00:00:00

abstract：:Plaque deposition in Alzheimer's disease (AD) is known to decrease proliferation in neurogenic niches in AD mouse models, but the effects on cell proliferation and differentiation in other brain areas have not been studied in detail. We analyzed cell proliferation in the cortex of wild type (WT) and APPswePS1dE9 trans...

journal_title：Glia

authors： Kamphuis W,Orre M,Kooijman L,Dahmen M,Hol EM

更新日期：2012-04-01 00:00:00

abstract：:Astrocytes play a key role regulating aspects of inflammation in the central nervous system (CNS). Several enzymes, such as the inducible nitric oxide synthase (iNOS) or the cyclooxygenase-2 (COX-2), along with different inflammatory mediators such as the free radical nitric oxide (NO) or proinflammatory cytokines, ha...

journal_title：Glia

authors： Ortega-Gutiérrez S,Molina-Holgado E,Guaza C

更新日期：2005-11-01 00:00:00

abstract：:Microglial activation has been reported to promote neurotoxicity and also neuroprotective effects. A possible contributor to this dichotomy of responses may be the degree to which proximal neurons are injured. The aim of this study was to determine whether varying the severity of neuronal injury influenced whether mic...

journal_title：Glia

authors： Lai AY,Todd KG

更新日期：2008-02-01 00:00:00

abstract：:In the course of adult hippocampal neurogenesis, new cells go through a series of stages associated with proliferative activity. The most highly proliferative cell type is an intermediate precursor cell, called type-2 cell. We here report that on the level of type-2 cells a transition takes place between features asso...

journal_title：Glia

authors： Steiner B,Klempin F,Wang L,Kott M,Kettenmann H,Kempermann G

更新日期：2006-12-01 00:00:00

abstract：:The receptors for the complement anaphylatoxins C3a and C5a are expressed by glial cells and neurons in normal and inflamed brain. Previous studies demonstrated modest elevations in mRNA expression of these receptors in a model of focal cerebral ischemia. Using a similar model system for both mice and rats, we report ...

journal_title：Glia

authors： Barnum SR,Ames RS,Maycox PR,Hadingham SJ,Meakin J,Harrison D,Parsons AA

更新日期：2002-04-15 00:00:00

abstract：:Astrocytes are thought to exert diverse functions in the brain, but it has been difficult to prove this in vivo because of a scarcity of tools to manipulate these cells. Here, we report the generation of new transgenic mouse lines that allow for conditional gene ablation in astrocytes using the tamoxifen- (TAM-) induc...

journal_title：Glia

authors： Slezak M,Göritz C,Niemiec A,Frisén J,Chambon P,Metzger D,Pfrieger FW

更新日期：2007-11-15 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) of the optic nerve are generated in the preoptic area, from where they migrate to colonize it entirely. Sonic hedgehog (Shh) induces the proliferation of these cells as well as influencing their migration, acting through its canonical receptor (Ptc-1). However, the multiligand re...

journal_title：Glia

authors： Ortega MC,Cases O,Merchán P,Kozyraki R,Clemente D,de Castro F

更新日期：2012-05-01 00:00:00

abstract：:The basic helix-loop-helix (bHLH) transcription factor Ascl1 plays crucial roles in both oligodendrocyte development and neuronal development; however, the molecular target of Ascl1 in oligodendrocyte progenitor cells (OPCs) remains elusive. To identify the downstream targets of Ascl1 in OPCs, we performed gene expres...

journal_title：Glia

authors： Ueno T,Ito J,Hoshikawa S,Ohori Y,Fujiwara S,Yamamoto S,Ohtsuka T,Kageyama R,Akai M,Nakamura K,Ogata T

更新日期：2012-10-01 00:00:00

abstract：:We demonstrate that there are significantly more p75 neurotrophin receptor- (NTR)-expressing cells in olfactory ensheathing cell (OEC) primary cultures from olfactory nerve rootlets (ONR), but a greater proportion of O4 antigen- and PSA-NCAM-expressing cells in parallel cultures from the nerve fibre layer of the olfac...

journal_title：Glia

authors： Kumar R,Hayat S,Felts P,Bunting S,Wigley C

更新日期：2005-04-01 00:00:00

abstract：:Aging is a major risk factor for the development of neurodegenerative diseases. Alzheimer's disease and other neurodegenerative diseases are characterized by abnormal and prominent protein aggregation in the brain, partially due to deficiency in protein clearance. It has been proposed that alterations in microglia pha...

journal_title：Glia

authors： Rodriguez-Callejas JD,Fuchs E,Perez-Cruz C

更新日期：2020-09-01 00:00:00

abstract：:The p75 neurotrophin receptor has been implicated in the regulation of multiple cellular functions that differ depending on the cell context. We have observed that p75(NTR) is strongly induced on astrocytes as well as neurons in the hippocampal CA3 region after seizures; however, the function of this receptor on these...

journal_title：Glia

authors： Cragnolini AB,Huang Y,Gokina P,Friedman WJ

更新日期：2009-10-01 00:00:00

abstract：:Th17 cells and interleukin-17 (IL-17) have been found to play an important role in the pathology of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Response to IL-17, reactive astrocytes accompany with immune cells infiltration and axonal damage in MS/EAE. However, the ro...

journal_title：Glia

authors： Liu X,Zhou F,Yang Y,Wang W,Niu L,Zuo D,Li X,Hua H,Zhang B,Kou Y,Guo J,Kong F,Pan W,Gao D,Meves JM,Sun H,Xue M,Zhang Q,Wang Y,Tang R

更新日期：2019-01-01 00:00:00

abstract：:In the last decade, microRNAs have been increasingly recognized as key modulators of glial development. Recently, we identified miR-125a-3p as a new player in oligodendrocyte physiology, regulating in vitro differentiation of oligodendrocyte precursor cells (OPCs). Here, we show that miR-125a-3p is upregulated in acti...

journal_title：Glia

authors： Marangon D,Boda E,Parolisi R,Negri C,Giorgi C,Montarolo F,Perga S,Bertolotto A,Buffo A,Abbracchio MP,Lecca D

更新日期：2020-10-01 00:00:00

abstract：:A growth cone-enriched fraction was prepared from 3-4 day rat cerebra. Examination of the growth cone fraction by electron microscopy revealed numerous structures circular in appearance that contain a number of features common to neuronal growth cones in vivo. The isolated growth cones stimulated a dose-dependent inco...

journal_title：Glia

authors： Dent EW,Ida JA Jr,Yoshino JE

更新日期：1992-01-01 00:00:00

abstract：:The predominant glial cells of the drone retina (outer pigment cells) respond to an increase in extracellular [K+] (Ko) by a net uptake of K+; thus, they contribute to bringing Ko back toward its baseline value. The authors report herein that there is also a different mechanism by which light stimulation of the retina...

journal_title：Glia

authors： Coles JA,Schneider-Picard G

更新日期：1989-01-01 00:00:00

abstract：:Neuroaxonal degeneration is a pathological hallmark of multiple sclerosis (MS) contributing to irreversible neurological disability. Pathological mechanisms leading to axonal damage include autoimmunity to neuronal antigens. In actively demyelinating lesions, myelin is phagocytosed by microglia and blood-borne macroph...

journal_title：Glia

authors： Huizinga R,van der Star BJ,Kipp M,Jong R,Gerritsen W,Clarner T,Puentes F,Dijkstra CD,van der Valk P,Amor S

更新日期：2012-03-01 00:00:00

abstract：:When central nervous system (CNS) homeostasis is altered, microglial cells become rapidly activated, proliferate and release a broad range of molecules. Among the plethora of molecules involved in the regulation of microglial activation, cytokines are considered crucial. Although production of interleukin-10 (IL-10) h...

journal_title：Glia

authors： Recasens M,Shrivastava K,Almolda B,González B,Castellano B

更新日期：2019-04-01 00:00:00

abstract：:The technology to generate autologous pluripotent stem cells (iPS cells) from almost any somatic cell type has brought various cell replacement therapies within clinical research. Besides the challenge to optimize iPS protocols to appropriate safety and GMP levels, procedures need to be developed to differentiate iPS ...

journal_title：Glia

authors： Czepiel M,Balasubramaniyan V,Schaafsma W,Stancic M,Mikkers H,Huisman C,Boddeke E,Copray S

更新日期：2011-06-01 00:00:00

abstract：:The effect of cholinergic agonists and antagonists on the intracellular free Ca2+ concentration ([Ca2+]i) of leech neuropile glial cells was investigated by use of iontophoretically injected fura-2. In neuropile glial cells, cholinergic agonists induced a marked increase in [Ca2+]i that was inhibited by d-tubocurarine...

journal_title：Glia

authors： Hochstrate P,Schlue WR

更新日期：1995-09-01 00:00:00

abstract：:Microglia transform from homeostatic to disease-associated-microglia (DAM) profiles in neurodegeneration. Within DAM, we recently identified distinct pro-inflammatory and anti-inflammatory sub-profiles although transcriptional regulators of homeostatic and distinct DAM profiles remain unclear. Informed by these studie...

journal_title：Glia

authors： Gao T,Jernigan J,Raza SA,Dammer EB,Xiao H,Seyfried NT,Levey AI,Rangaraju S

更新日期：2019-10-01 00:00:00

abstract：:Sciatic nerve explants cultured either alone or in the presence of peritoneal macrophages were used to study prostaglandin E(2) (PGE(2)) and 6-keto-PGF(1alpha) production following traumatic peripheral nerve injury. Although barely detectable at early time points (1-3 h in vitro), the production of PGE(2) and 6-keto-P...

journal_title：Glia

authors： Muja N,DeVries GH

更新日期：2004-04-15 00:00:00

abstract：:It is now generally accepted that massive neuronal death due to oxidative stress is a regular feature of brains in neurodegenerative diseases. However, much less attention has been given to the death of glial cells. In this study, we examined p53-sensitive apoptosis of cells by using human glioblastoma A172 cells and ...

journal_title：Glia

authors： Kitamura Y,Ota T,Matsuoka Y,Tooyama I,Kimura H,Shimohama S,Nomura Y,Gebicke-Haerter PJ,Taniguchi T

更新日期：1999-01-15 00:00:00