Abstract:
:We analyze a two-state stochastic corral model for regulation of protein diffusion in a cell membrane. This model could mimic control of protein transport in the membrane by the cytoskeleton. The dynamic corral acts as a gate which when open permits an otherwise trapped protein to escape to a neighboring corral in the cytoskeletal network. We solve for the escape rate over a wide range of parameters of the model, and compare these results with Monte Carlo simulations. Upon introducing measured values of the model parameters for Band 3 in erythrocyte membranes, we are able to estimate the value for one unknown parameter, the average rate at which the corral closes. The ratio of calculated closing rate to measured opening rate is roughly 100:1, consistent with a gating mechanism whereby protein mobility is regulated by dissociation and reassociation of segments of the cytoskeletal network.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Leitner DM,Brown FL,Wilson KRdoi
10.1016/S0006-3495(00)76579-9subject
Has Abstractpub_date
2000-01-01 00:00:00pages
125-35issue
1eissn
0006-3495issn
1542-0086pii
S0006-3495(00)76579-9journal_volume
78pub_type
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