Muscle regeneration: molecular aspects and therapeutic implications.

abstract：PURPOSE OF REVIEW:Clinical MRI is of paramount importance for multiple sclerosis diagnosis but lacks the specificity to investigate the pathogenic mechanisms underlying disease onset and progression. The application of advanced MR sequences allows the characterization of diverse and complex pathological mechanisms, gra...

journal_title：Current opinion in neurology

authors： Inglese M,Petracca M

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:We present an overview of recent concepts in mechanisms underlying cognitive decline associated with brain aging and neurodegeneration from the perspective of MRI. RECENT FINDINGS:Recent findings challenge the established link between neuroimaging biomarkers of neurodegeneration and age-related or di...

journal_title：Current opinion in neurology

authors： Draganski B,Lutti A,Kherif F

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The relative influence of genes and environment on the liability to neurodevelopmental disorders (NDDs) can be investigated using a twin design. This review highlights the results of the most recent twin studies of NDDs. RECENT FINDINGS:Recent twin studies have confirmed that NDDs show moderate-to-hi...

journal_title：Current opinion in neurology

authors： Posthuma D,Polderman TJ

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The development of successful myelin repair strategies depends on the detailed knowledge of the cellular and molecular processes underlying demyelination and remyelination in the central nervous system of animal models and in patients with multiple sclerosis (MS). Based on the complexity of the demyel...

journal_title：Current opinion in neurology

authors： Gallo V,Armstrong RC

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review draws together the most recent findings in ALS biomarker research from biochemical, imaging and neurophysiology techniques. RECENT FINDINGS:The potential of circulating RNA is highlighted, including new retrieval techniques. With ongoing genetic clinical trials, the need for pharmacodynam...

journal_title：Current opinion in neurology

authors： Verber N,Shaw PJ

更新日期：2020-10-01 00:00:00

abstract：:Trauma to the developing brain constitutes an unexplored field. The few studies attempting to model and study paediatric head trauma, the leading cause of death and disability in the paediatric population, have revealed interesting aspects and potential targets for future research. One feature unique to the developing...

journal_title：Current opinion in neurology

authors： Felderhoff-Mueser U,Ikonomidou C

更新日期：2000-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The computational power of the brain arises from the complex interactions between neurons. One straightforward method to quantify the strength of neuronal interactions is by measuring correlation and coherence. Efforts to measure correlation have been advancing rapidly of late, spurred by the developm...

journal_title：Current opinion in neurology

authors： Snyder AC,Smith MA

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Homonymous hemianopia is the commonest form of acquired homonymous visual field defect; the usual causes are stroke, head injury and intracranial tumours. This impairment can affect a variety of cognitive visual functions, including visual search, safe navigation through changing environments and read...

journal_title：Current opinion in neurology

authors： Schofield TM,Leff AP

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Human ischemic stroke is a multistage disorder with different options for recovery. Imaging has opened a window to explore the pathophysiology and recovery mechanisms of ischemic stroke in vivo. RECENT FINDINGS:It was shown that in the acute phase, arterial recanalization and reperfusion are the most...

journal_title：Current opinion in neurology

authors： Seitz RJ

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describe the role and advancements of MRI in the diagnosis and monitoring of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis patients treated with natalizumab. RECENT FINDINGS:MRI is the most sensitive paraclinical tool in the detection of PML lesions in natalizumab...

journal_title：Current opinion in neurology

authors： Wattjes MP,Barkhof F

更新日期：2014-06-01 00:00:00

abstract：:Slowly, advances are being made in the understanding and treatment of primary childhood brain tumors. The addition of chemotherapy has resulted in better survival for children with medulloblastoma. For other tumor types, therapeutic advances have been slower. High-dose chemotherapy is increasingly being employed to tr...

journal_title：Current opinion in neurology

authors： Packer RJ

更新日期：1997-12-01 00:00:00

abstract：:The ability to recognize elements of the environment as familiar objects, events, or classes underlies virtually all human cognition. Positron emission tomography and functional magnetic resonance imaging studies of the recognition of visually presented objects suggest that several brain areas crucially support this f...

journal_title：Current opinion in neurology

authors： Bly BM,Kosslyn SM

更新日期：1997-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past 25 years, many autoantibodies directed against peripheral nerve glycan and protein antigens have been described. Principally through this area of research, significant advances have been achieved in the understanding of the pathophysiology of inflammatory neuropathies. More evidence cons...

journal_title：Current opinion in neurology

authors： Chavada G,Willison HJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize why there are polarized opinions regarding the management of patients with asymptomatic carotid disease and whether it is possible to identify patients who might benefit from carotid interventions. RECENT FINDINGS:Carotid Revascularization Endarterectomy Versus Stenting Trial and Asympto...

journal_title：Current opinion in neurology

authors： Naylor AR

更新日期：2017-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Research on multiple sclerosis (MS) pathogenesis and therapy is to a large extent driven by results obtained in experimental autoimmune encephalomyelitis (EAE). This approach provided deep insights into the mechanism of brain inflammation and immune mediated tissue injury and, thus, most of our curren...

journal_title：Current opinion in neurology

authors： Lassmann H

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:New insights into the psychophysiological determinants of performance changes and brain plasticity associated with motor sequence learning have recently been gained through behavioral and imaging studies in healthy individuals. In addition, using a variety of motor sequential paradigms in groups of pa...

journal_title：Current opinion in neurology

authors： Doyon J

更新日期：2008-08-01 00:00:00

abstract：:Mild cognitive impairment is not an established diagnosis but a concept for which different criteria have been proposed and modified over time. Mild cognitive impairment refers to the transitional zone between normal ageing and dementia. The mild cognitive impairment stage may be one of the optimum stages at which to ...

journal_title：Current opinion in neurology

authors： Voisin T,Touchon J,Vellas B

更新日期：2003-12-01 00:00:00

abstract：:A relatively small number of studies were published on the intra-arterial therapy of stroke in the past year. Those reports, however, do offer strong evidence for the feasibility and safety of this therapeutic approach. Partly on the basis of these data it has become evident that the intra-arterial thrombolytic therap...

journal_title：Current opinion in neurology

authors： Abou-Chebl A,Furlan AJ

更新日期：2000-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To give an overview on topics of pupillary function selected according to their relevance in clinical neurology. Mainly publications of the last 3 years have been considered. RECENT FINDINGS:The discovery of photosensitive retinal ganglion cells not serving vision, but serving circadian rhythm and th...

journal_title：Current opinion in neurology

authors： Wilhelm H

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to review recent publications on amyotrophic lateral sclerosis (ALS). RECENT FINDINGS:The Awaji recommendations for electrophysiological diagnosis will permit earlier clinical trials entry. The use of ultrasound to visualize fasciculations, even in deep muscles, will contribute to earlier ...

journal_title：Current opinion in neurology

authors： de Carvalho M,Swash M

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review considers the role of neuroimaging in developmental disorders by highlighting recent studies in two distinct, but overlapping, developmental disorders: autism and fragile X syndrome. RECENT FINDINGS:After a decade of conflicting results in neuroimaging studies of autism, recent studies ha...

journal_title：Current opinion in neurology

authors： Greicius MD

更新日期：2003-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review of recent work in the area of neurorehabilitation of multiple sclerosis patients surveys progress and underscores the need for further work to evaluate the effectiveness of treatments. RECENT FINDINGS:Several recent review documents have summarized the current position regarding neuroreha...

journal_title：Current opinion in neurology

authors： Thompson AJ

更新日期：2005-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To gain a complete understanding of how the brain functions, both in illness and good health, data from multiple levels of analysis must be integrated. Technical advances have made direct recordings of neuronal activity deep inside the human brain tractable, providing a rare glimpse into cellular proc...

journal_title：Current opinion in neurology

authors： Viskontas IV

更新日期：2008-12-01 00:00:00

abstract：:Demyelination and inflammation both contribute to the neurological deficits characteristic of multiple sclerosis and Guillain-Barré syndrome. Conduction deficits attributable to demyelination are well known, but it is becoming clear that factors such as nitric oxide, endocaine, cytokines, and antiganglioside antibodie...

journal_title：Current opinion in neurology

authors： Smith KJ,Hall SM

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the clinical findings, differential diagnosis, treatment and outcome of pseudotumoral demyelinating lesions including tumefactive demyelination and Baló's concentric sclerosis. RECENT FINDINGS:MRI findings, such as dynamic restricted diffusion changes at the edge of pseudotumoral lesions he...

journal_title：Current opinion in neurology

authors： Hardy TA

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Multiple sclerosis (MS) is an autoimmune and inflammatory disease of the central nervous system (CNS) that causes neurological disability in young adults and that to date has no cure. Until now, expensive and only partially efficacious therapies have become available. For this reason, researchers, cli...

journal_title：Current opinion in neurology

authors： Mangas A,Coveñas R,Geffard M

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on the major advances in inflammatory myopathies. RECENT FINDINGS:Polymyositis is an uncommon disorder that can be misdiagnosed when the old, and never validated, criteria of Bohan and Peter are used. New diagnostic criteria were recently introduced, in which the MHC/CD8 complex ...

journal_title：Current opinion in neurology

authors： Dalakas MC

更新日期：2004-10-01 00:00:00

abstract：:Magnetic resonance spectroscopy provides noninvasive insight into the regional and global biochemical alterations that are concomitants of the dynamic processes that underlie the evolution of fundamental pathologic changes in multiple sclerosis. These include now well-recognized alterations of neuronal biochemical mar...

journal_title：Current opinion in neurology

authors： Wolinsky JS,Narayana PA

更新日期：2002-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Frontotemporal dementia (FTD) is a clinically, pathologically and genetically heterogeneous disorder. Mutations in a number of genes are associated with FTD, although until recently only two [progranulin (GRN) and microtubule-associated protein tau (MAPT)] were known to be major causes of the disease....

journal_title：Current opinion in neurology

authors： Rohrer JD,Warren JD

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Trigeminal autonomic cephalgias (TACs) are characterized by frequent, short-lasting headache attacks with ipsilateral facial autonomic features. They include cluster headache, paroxysmal hemicrania, and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing. The...

journal_title：Current opinion in neurology

authors： Wilbrink LA,Ferrari MD,Kruit MC,Haan J

更新日期：2009-06-01 00:00:00