Estimations of the efficacy and reliability of paternity assignments from DNA microsatellite analysis of multiple-sire matings.

Abstract:

:It is important for bovine DNA testing laboratories to provide the cattle industry with accurate estimates of the efficacy and reliability of DNA tests offered so that end users of this technology can adequately assess the cost-benefits of testing. To address these issues for bovine paternity testing, paternity exclusion probability estimates were obtained from breed panel data and were predictive of the efficacy of the DNA tests used in 39 multiple-sire mating groups, involving 5960 calves and 505 bulls. Paternity testing of these mating groups has demonstrated that the majority involve a variable proportion of unknown sires and this impacts on the reliability of sire allocation. Mathematical models based on binomial or beta-binomial probability distributions were used to estimate the reliability of single-sire allocations from multiple-sire matings involving unknown sires. Reliability of 98-99% is achieved when the exclusion probability is 0.99 or greater, after allowing for up to 20% unknown sires. When the exclusion probability drops below 0.90 and there are 20% unknown sires, the reliability is poor, bringing into question the benefits of testing. This highlights the need for DNA testing laboratories to offer paternity tests with an exclusion power of at least 99%.

journal_name

Anim Genet

journal_title

Animal genetics

authors

Vankan DM,Faddy MJ

doi

10.1046/j.1365-2052.1999.00511.x

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

355-61

issue

5

eissn

0268-9146

issn

1365-2052

journal_volume

30

pub_type

杂志文章
  • A transposable element insertion in APOB causes cholesterol deficiency in Holstein cattle.

    abstract::Cholesterol deficiency, a new autosomal recessive inherited genetic defect in Holstein cattle, has been recently reported to have an influence on the rearing success of calves. The affected animals show unresponsive diarrhea accompanied by hypocholesterolemia and usually die within the first weeks or months of life. H...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12410

    authors: Menzi F,Besuchet-Schmutz N,Fragnière M,Hofstetter S,Jagannathan V,Mock T,Raemy A,Studer E,Mehinagic K,Regenscheit N,Meylan M,Schmitz-Hsu F,Drögemüller C

    更新日期:2016-04-01 00:00:00

  • On measures of association among genetic variables.

    abstract::Systems involving many variables are important in population and quantitative genetics, for example, in multi-trait prediction of breeding values and in exploration of multi-locus associations. We studied departures of the joint distribution of sets of genetic variables from independence. New measures of association b...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2012.02326.x

    authors: Gianola D,Manfredi E,Simianer H

    更新日期:2012-07-01 00:00:00

  • Quantitative trait loci for litter size and prenatal loss in a White Duroc x Chinese Erhualian resource population.

    abstract::To detect quantitative trait loci (QTL) for litter size related traits, the total number of born piglets (TNB), the number of born alive piglets (NBA), the number of stillborn piglets (NSB) and the number of mummies (NM) at the first parity were recorded in 299 F(2) sows in a White Duroc x Chinese Erhualian intercross...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01931.x

    authors: Li K,Ren J,Xing Y,Zhang Z,Ma J,Guo Y,Huang L

    更新日期:2009-12-01 00:00:00

  • Farm-by-farm analysis of microsatellite, mtDNA and SNP genotype data reveals inbreeding and crossbreeding as threats to the survival of a native Spanish pig breed.

    abstract::The Chato Murciano (CM), a pig breed from the Murcia region in the southeastern region of Spain, is a good model for endangered livestock populations. The remaining populations are bred on approximately 15 small farms, and no herdbook exists. To assess the genetic threats to the integrity and survival of the CM breed,...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12001

    authors: Herrero-Medrano JM,Megens HJ,Crooijmans RP,Abellaneda JM,Ramis G

    更新日期:2013-06-01 00:00:00

  • Identifying genetic loci controlling neonatal passive transfer of immunity using a hybrid genotyping strategy.

    abstract::Colostrum intake is critical to a piglet's survival and can be measured by precipitating out the γ-immunoglobulins from serum with ammonium sulfate (immunocrit). Genetic analysis of immunocrits on 5312 piglets indicated that the heritabilities (se) for direct and maternal effects were 0.13 (0.06) and 0.53 (0.08) respe...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12131

    authors: Rohrer GA,Rempel LA,Miles JR,Keele JW,Wiedmann RT,Vallet JL

    更新日期:2014-06-01 00:00:00

  • Accuracy of genomic selection for age at puberty in a multi-breed population of tropically adapted beef cattle.

    abstract::Genomic selection is becoming a standard tool in livestock breeding programs, particularly for traits that are hard to measure. Accuracy of genomic selection can be improved by increasing the quantity and quality of data and potentially by improving analytical methods. Adding genotypes and phenotypes from additional b...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12362

    authors: Farah MM,Swan AA,Fortes MR,Fonseca R,Moore SS,Kelly MJ

    更新日期:2016-02-01 00:00:00

  • Genetic diversity analysis of French goat populations reveals selective sweeps involved in their differentiation.

    abstract::After domestication 11 000 years ago in Asia Minor, the goat followed human migration to Europe and Asia. It was then introduced in Africa and is now raised all over the world. In this study, we exploited a dataset composed of 54 000 SNPs (Illumina goat DNA chip) to analyze the genetic diversity of 223 individuals bel...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12752

    authors: Oget C,Servin B,Palhière I

    更新日期:2019-02-01 00:00:00

  • Polymorphisms in MHC-DRA and -DRB alleles of water buffalo (Bubalus bubalis) reveal different features from cattle DR alleles.

    abstract::Seventy-five individuals of Bubalus bubalis belonging to four different breeds, three of river buffalo and one of swamp buffalo, were studied for polymorphism in MHC DRB (Bubu-DRB) and DRA (Bubu-DRA) loci. Eight alleles of Bubu-DRB were found, and all alleles in the swamp type were shared with the three river breeds. ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2003.00920.x

    authors: Sena L,Schneider MP,Brenig B,Honeycutt RL,Womack JE,Skow LC

    更新日期:2003-02-01 00:00:00

  • Mapping and characterization of the DQ subregion of the ovine MHC.

    abstract::A map of the ovine MHC class II DQ subregion has been constructed from overlapping cosmid clones. This region consists of two loci linked on a linear tract of 130 kb DNA. Each locus consists of a DQA and a DQB gene in a tail-to-tail orientation. The genes in each locus are transcribed but only those designated DQ1 exp...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1994.tb00200.x

    authors: Wright H,Ballingall KT

    更新日期:1994-08-01 00:00:00

  • Genetic variation in the bovine myostatin gene in UK beef cattle: allele frequencies and haplotype analysis in the South Devon.

    abstract::Work on Belgian Blue cattle revealed that an 11 base pair (bp) deletion within the bovine myostatin gene (GDF8) is associated with the double-muscled phenotype seen in this breed. Investigations focusing on other European breeds known to show double-muscling identified several mutations within the coding region of the...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2000.00521.x

    authors: Smith JA,Lewis AM,Wiener P,Williams JL

    更新日期:2000-10-01 00:00:00

  • A genome-wide scan for tying-up syndrome in Japanese Thoroughbreds.

    abstract::Tying-up syndrome, also known as recurrent exertional rhabdomyolysis in Thoroughbreds, is a common muscle disorder for racehorses. In this study, we performed a multipoint linkage analysis using LOKI based on the Bayesian Markov chain Monte Carlo method using 5 half-sib families (51 affected and 277 nonaffected horses...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02112.x

    authors: Tozaki T,Hirota K,Sugita S,Ishida N,Miyake T,Oki H,Hasegawa T

    更新日期:2010-12-01 00:00:00

  • Microphthalmia-associated transcription factor mutations are associated with white-spotted coat color in swamp buffalo.

    abstract::A candidate gene analysis of the microphthalmia-associated transcription factor (MITF) gene was used in an attempt to identify the genetic basis for a white-spotted coat color phenotype in the Asian swamp buffalo (Bubalus bubalis carabanensis). Ninety-three buffaloes-32 solid, 38 spotted and 23 white individuals-were ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12334

    authors: Yusnizar Y,Wilbe M,Herlino AO,Sumantri C,Noor RR,Boediono A,Andersson L,Andersson G

    更新日期:2015-12-01 00:00:00

  • From information to understanding: the role of model organism databases in comparative and functional genomics.

    abstract::Data integration is key to functional and comparative genomics because integration allows diverse data types to be evaluated in new contexts. To achieve data integration in a scalable and sensible way, semantic standards are needed, both for naming things (standardized nomenclatures, use of key words) and also for kno...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2006.01475.x

    authors: Bult CJ

    更新日期:2006-08-01 00:00:00

  • Restriction site heteroplasmy in the mitochondrial DNA of the marine fish Sciaenops ocellatus (L.).

    abstract::Restriction site heteroplasmy involving the enzymes NcoI and XbaI was detected in the mitochondrial DNAs of two individuals of the marine fish Sciaenops ocellatus. This represents only the sixth documented example of mitochondrial DNA restriction site heteroplasmy in animals. Two heteroplasmic individuals were found i...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1990.tb03241.x

    authors: Gold JR,Richardson LR

    更新日期:1990-01-01 00:00:00

  • Restriction fragment length polymorphism among Israeli Holstein-Friesian dairy bulls.

    abstract::Israeli Holstein-Friesian dairy bulls were screened for restriction fragment length polymorphisms by hybridizing cloned DNA probes for bovine growth hormone, for chymosin, and for rat muscle beta-actin to restriction endonuclease-digested DNA immobilized on nitrocellulose filters. The population proved to be polymorph...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1986.tb03185.x

    authors: Beckmann JS,Kashi Y,Hallerman EM,Nave A,Soller M

    更新日期:1986-01-01 00:00:00

  • Linkage disequilibrium and historical effective population size in the Thoroughbred horse.

    abstract::Many genomic methodologies rely on the presence and extent of linkage disequilibrium (LD) between markers and genetic variants underlying traits of interest, but the extent of LD in the horse has yet to be comprehensively characterized. In this study, we evaluate the extent and decay of LD in a sample of 817 Thoroughb...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2010.02092.x

    authors: Corbin LJ,Blott SC,Swinburne JE,Vaudin M,Bishop SC,Woolliams JA

    更新日期:2010-12-01 00:00:00

  • Genome-wide identification of quantitative trait loci in a cross between Hampshire and Landrace I: carcass traits.

    abstract::We report the identification of quantitative trait loci (QTL) affecting carcass composition, carcass length, fat deposition and lean meat content using a genome scan across 462 animals from a combined intercross and backcross between Hampshire and Landrace pigs. Data were analysed using multiple linear regression fitt...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2005.01405.x

    authors: Karlskov-Mortensen P,Bruun CS,Braunschweig MH,Sawera M,Markljung E,Enfält AC,Hedebro-Velander I,Josell A,Lindahl G,Lundström K,von Seth G,Jørgensen CB,Andersson L,Fredholm M

    更新日期:2006-04-01 00:00:00

  • Intrageneric amplification of horse microsatellite markers with emphasis on the Przewalski's horse (E. przewalskii).

    abstract::Primer sequences flanking 13 microsatellite loci isolated from the domestic horse (E. caballus) were successfully used to amplify homologous loci in the Przewalski's horse (E. przewalskii). The results demonstrate that the level of polymorphism at all 13 loci in the Przewalski's horse was comparable to that in the dom...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1994.tb00530.x

    authors: Breen M,Downs P,Irvin Z,Bell K

    更新日期:1994-12-01 00:00:00

  • Isolation and sequencing of porcine lipoprotein lipase cDNA and its use in multiallelic restriction fragment length polymorphism detection.

    abstract::Porcine lipoprotein lipase (LPL) cDNA has been cloned and sequenced. The deduced amino acid sequence shows a high degree of identity to LPL from other species, and contains the Ser/His/Asp triade characteristic of serine proteases and esterases. A repetitive element is present in the 3'-untranslated region of the cDNA...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1992.tb00170.x

    authors: Harbitz I,Kristensen T,Kran S,Davies W

    更新日期:1992-01-01 00:00:00

  • Breed-specific expression of DROSHA, DICER and AGO2 is regulated by glucocorticoid-mediated miRNAs in the liver of newborn piglets.

    abstract::MicroRNA (miRNA) biogenesis is determined mainly by Drosha, Dicer and Argonaute2 (Ago2). Different breeds of pigs with vast differences in serum cortisol level demonstrate distinct profiles of hepatic miRNA expression. As yet, little is known about whether glucocorticoid contributes to the breed differences in miRNA b...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12232

    authors: Li R,Jia Y,Zou H,Zhao R

    更新日期:2014-12-01 00:00:00

  • A linkage map of common carp (Cyprinus carpio) based on AFLP and microsatellite markers.

    abstract::Common carp (Cyprinus carpio) is an important fish for aquaculture, but genomics of this species is still in its infancy. In this study, a linkage map of common carp based on Amplified Fragment Length Polymorphism (AFLP) and microsatellite (SSR) markers has been generated using gynogenetic haploids. Of 926 markers gen...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2009.01985.x

    authors: Cheng L,Liu L,Yu X,Wang D,Tong J

    更新日期:2010-04-01 00:00:00

  • Two MC1R loss-of-function alleles in cream-coloured Australian Cattle Dogs and white Huskies.

    abstract::Loss-of-function variants in the MC1R gene cause recessive red or yellow coat-colour phenotypes in many species. The canine MC1R:c.916C>T (p.Arg306Ter) variant is widespread and found in a homozygous state in many uniformly yellow- or red-coloured dogs. We investigated cream-coloured Australian Cattle Dogs whose coat ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12660

    authors: Dürig N,Letko A,Lepori V,Hadji Rasouliha S,Loechel R,Kehl A,Hytönen MK,Lohi H,Mauri N,Dietrich J,Wiedmer M,Drögemüller M,Jagannathan V,Schmutz SM,Leeb T

    更新日期:2018-08-01 00:00:00

  • A PCR-RFLP for KIT associated with tobiano spotting pattern in horses.

    abstract::An MspI polymorphism was identified in intron 13 of the equine homologue of proto-oncogene c-kit (KIT) by comparing DNA sequences from horses with solid coat colour and horses homozygous for the tobiano spotting (To) gene. The allele associated with solid coat colour was designated KM0, while the allele associated wit...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.2002.00854.x

    authors: Brooks SA,Terry RB,Bailey E

    更新日期:2002-08-01 00:00:00

  • Canine plasma alkaline phosphatase polymorphism and its relationship with the canine Tr blood group system.

    abstract::A canine blood group antigen, QN, which was detected by a naturally occurring alloantibody in the antiglobulin test, was shown to be antigenically related to the human A and cattle J antigens by absorption experiments. Family studies supported a dominant mode of inheritance with the gene controlling the production of ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1992.tb00153.x

    authors: Symons M,Bell K

    更新日期:1992-01-01 00:00:00

  • Diagnostic value of a microsatellite DNA marker for copper toxicosis in West-European Bedlington terriers and incidence of the disease.

    abstract::Recently, linkage of a DNA microsatellite marker to inherited copper toxicosis has been reported in American Bedlington terrier families. Due to the fact that there is little exchange of breeding stock between the USA and Europe, it remains to be investigated whether in Europe the marker is informative and is linked w...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2052.1999.00451.x

    authors: Rothuizen J,Ubbink GJ,van Zon P,Teske E,van den Ingh TS,Yuzbasiyan-Gurkan V

    更新日期:1999-06-01 00:00:00

  • Genomic structure and gene order of swine chromosome 7q1.1-->q1.2.

    abstract::To clarify the structure of the porcine genomic region that contains quantitative trait loci (QTL) related to fat, we constructed a bacterial artificial chromosome (BAC) contig of the region from DST to SRPK1 on porcine chromosome 7 and performed low-redundancy 'skim' shotgun sequencing of the clones that composed a m...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.2005.01362.x

    authors: Tanaka M,Suzuki K,Morozumi T,Kobayashi E,Matsumoto T,Domukai M,Eguchi-Ogawa T,Shinkai H,Awata T,Uenishi H

    更新日期:2006-02-01 00:00:00

  • Combined approaches to reveal genes associated with litter size in Yunshang black goats.

    abstract::Intensive artificial selection has been imposed in Yunshang black goats, the first black specialist mutton goat breed in China, with a breeding object of improving reproductive performance, which has contributed to reshaping of the genome including the characterization of SNP, ROH and haplotype. However, variation in ...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12999

    authors: Tao L,He XY,Jiang YT,Lan R,Li M,Li ZM,Yang WF,Hong QH,Chu MX

    更新日期:2020-12-01 00:00:00

  • Detecting selection signatures in three Iranian sheep breeds.

    abstract::The objective of genome mapping is to achieve valuable insight into the connection between gene variants (genotype) and observed traits (phenotype). Part of that objective is to understand the selective forces that have operated on a population. Finding links between genotype-phenotype changes makes it possible to ide...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12772

    authors: Manzari Z,Mehrabani-Yeganeh H,Nejati-Javaremi A,Moradi MH,Gholizadeh M

    更新日期:2019-06-01 00:00:00

  • Linkage disequilibrium over short physical distances measured in sheep using a high-density SNP chip.

    abstract::The extent of linkage disequilibrium (LD) between genetic loci has implications for both association studies and the accuracy of genomic prediction. To characterise the persistence of LD in diverse sheep breeds, two SNP genotyping platforms were used. First, existing SNP genotypes from 63 breeds obtained using the ovi...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/age.12197

    authors: Kijas JW,Porto-Neto L,Dominik S,Reverter A,Bunch R,McCulloch R,Hayes BJ,Brauning R,McEwan J,International Sheep Genomics Consortium.

    更新日期:2014-10-01 00:00:00

  • Phenotyping of pig alpha 1B-glycoprotein (PO2) and haemopexin by 1D polyacrylamide gel electrophoresis and immunoblotting.

    abstract::Described is an alternative procedure for the phenotyping of pig alpha 1B-glycoprotein (PO2) and haemopexin. The procedure is based on the separation of serum samples by horizontal polyacrylamide gel electrophoresis, passive blotting onto a nitrocellulose (NC) sheet, and immunochemical detection using a mixture of a p...

    journal_title:Animal genetics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2052.1989.tb00870.x

    authors: Kaláb P,Stratil A

    更新日期:1989-01-01 00:00:00