Abstract:
:Ogi-Keishi-Gomotsu-To-Ka-Kojin (OKGK) is a traditional herbal medicine (Kampo medicine) which has been found to ameliorate hypercholesterolemia and hypertriglyceridemia in rats and rabbits. In the present study, the effect of OKGK on acyl-CoA:cholesterol acyltransferase (ACAT) was studied in order to elucidate the mechanism of its antihypercholesterolemic action. Oral administration of OKGK to rats fed a cholesterol-enriched diet for 4 weeks markedly repressed the increase in ACAT activity in the small intestine. In contrast, OKGK did not influence hepatic ACAT activity. These results indicate that OKGK selectively inhibits ACAT activity in the small intestine relative to that in the liver, resulting in a reduction of cholesterol absorption, followed by a decrease in serum cholesterol.
journal_name
Biol Pharm Bulljournal_title
Biological & pharmaceutical bulletinauthors
Wu CZ,Inoue M,Ogihara Ydoi
10.1248/bpb.22.994subject
Has Abstractpub_date
1999-09-01 00:00:00pages
994-6issue
9eissn
0918-6158issn
1347-5215journal_volume
22pub_type
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