Development of the fluorescent microsphere technique for quantifying regional blood flow in small mammals.

abstract：NEW FINDINGS:What is the central question of this study? The parasternal intercostal electromyogram (EMGpara) is known to provide an accurate, non-invasive index of respiratory load-capacity balance. Although relationships between EMGpara and both airflow obstruction and hyperinflation have been shown, the independent ...

journal_title：Experimental physiology

authors： MacBean V,Pringle CL,Lunt AC,Sharp KD,Ali A,Greenough A,Moxham J,Rafferty GF

更新日期：2017-04-01 00:00:00

abstract：:It is unknown whether changes in corticomotor excitability follow prolonged exercise in healthy humans. Furthermore, the role of supraspinal fatigue in decrements of force production and voluntary activation following prolonged exercise has not been established. This study investigated peripheral and central fatigue a...

journal_title：Experimental physiology

authors： Ross EZ,Middleton N,Shave R,George K,Nowicky A

更新日期：2007-03-01 00:00:00

abstract：:Duchenne muscular dystrophy is a devastating muscular dystrophy of childhood. Mutations in the dystrophin gene destroy the link between the internal muscle filaments and the extracellular matrix, resulting in severe muscle weakness and progressive muscle wasting. There is currently no cure and, whilst palliative treat...

journal_title：Experimental physiology

authors： Fairclough RJ,Bareja A,Davies KE

更新日期：2011-11-01 00:00:00

abstract：:The properties of two types of calcium current (ICa(T) and ICa(L)) and their relationship with contraction were studied in isolated frog atrial trabeculae using the double mannitol gap technique. In Ringer solution containing TTX the calcium currents observed are similar to the ICa(T) and ICa(L) found in single frog a...

journal_title：Experimental physiology

authors： Badaoui A,Léoty C

更新日期：1994-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does the combination of methazolamide and theophylline reduce symptoms of acute mountain sickness (AMS) and improve aerobic performance in acute hypobaric hypoxia? What is the main finding and its importance? The oral combination of methazolamide (100 BID) and th...

journal_title：Experimental physiology

authors： Subudhi AW,Evero O,Reitinger J,Davis C,Gronewold J,Nichols AJ,Van-Houten SJ,Roach RC

更新日期：2021-01-01 00:00:00

abstract：:The aim of the present study was to assess the influence of body posture on post-submaximal exercise parasympathetic reactivation and to examine whether this influence was preserved under a heightened sympathetic background. On four occasions, eleven moderately trained subjects (22.1 +/- 3.0 years old) performed, in r...

journal_title：Experimental physiology

authors： Buchheit M,Al Haddad H,Laursen PB,Ahmaidi S

更新日期：2009-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is electrical pulse stimulation (EPS) an in vitro exercise model able to elicit the hypertrophy of human muscle cells? What is the main finding and its importance? The addition of a restitution period of 8 h after EPS induces the enlargement of human muscle cells...

journal_title：Experimental physiology

authors： Tarum J,Folkesson M,Atherton PJ,Kadi F

更新日期：2017-11-01 00:00:00

abstract：:Neuropeptides and regulatory peptide hormones control many developmental, physiological and behavioural processes in animals, including humans. The nonapeptides oxytocin and arginine vasopressin are produced and released by the pituitary gland and have actions on many organs and tissues. Receptive cells possess partic...

journal_title：Experimental physiology

authors： Gruber CW

更新日期：2014-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the characteristics of the NK cell response following acute moderate-intensity aerobic exercise in prostate cancer survivors and is there a relationship between stress hormones and NK cell mobilization? What is the main finding and its importance? NK cel...

journal_title：Experimental physiology

authors： Hanson ED,Sakkal S,Que S,Cho E,Spielmann G,Kadife E,Violet JA,Battaglini CL,Stoner L,Bartlett DB,McConell GK,Hayes A

更新日期：2020-09-01 00:00:00

abstract：:The pathogenesis of the vasodilatation associated with liver cirrhosis is not fully understood, but it has recently been postulated that it may be related to an increase in nitric oxide production. The aim of this study was to compare the response of isolated aortic rings from normal and cirrhotic rats to two vasocons...

journal_title：Experimental physiology

authors： Van Obbergh L,Leonard V,Chen H,Xu D,Blaise G

更新日期：1995-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Regulation of cardiac function is typically achieved by changes in heart rate (HR) and cardiac shortening velocity (strain rate; SR), but their interdependence in vivo remains poorly understood. What is the main finding and its importance? Using resistance exerci...

journal_title：Experimental physiology

authors： Stöhr EJ,Stembridge M,Esformes JI

更新日期：2015-04-20 00:00:00

abstract：:One of the most basic computational elements within a circuit is the synapse across which signals are transferred. Here we summarize some experimental strategies that allow the synaptic basis of circuit function to be studied through imaging. The two most promising approaches available currently are pHluorin-based rep...

journal_title：Experimental physiology

authors： Dreosti E,Lagnado L

更新日期：2011-01-01 00:00:00

abstract：:The aims of this study were: (1) to determine the within-subject, between-day variability in end-tidal P(CO2) (P(ET,CO2)); (2) to determine whether the within-subject, between-day variability in P(ET,CO2) was caused by variations in metabolic acid-base status; and (3) to determine whether between-subject variations in...

journal_title：Experimental physiology

authors： Crosby A,Robbins PA

更新日期：2003-09-01 00:00:00

abstract：:The purpose of the present study was to characterize the Ca2+ channels in smooth muscle cells from human stomach and to examine the effects of osmotic swelling on the channel activity. Ca2+ channel current with either Ca2+ or Ba2+ as charge carrier was recorded from freshly isolated smooth muscle cells using the conve...

journal_title：Experimental physiology

authors： Kim CH,Rhee PL,Rhee JC,Kim YI,So I,Kim KW,Park MK,Uhm DY,Kang TM

更新日期：2000-09-01 00:00:00

abstract：:Recently attempts have been made to analyse blood pressure (BP) and renal sympathetic nerve activity (RSNA) to determine how patterns contained within them might reflect control by the autonomic nervous system. To date, these studies have primarily used coherence analysis of BP and RSNA in the frequency domain. Howeve...

journal_title：Experimental physiology

authors： Yang Z,Zhang T,Coote JH

更新日期：2002-07-01 00:00:00

abstract：:The Flinders sensitive line (FSL) rats exhibit an increased cholinergic responsiveness in vivo when compared to their counterparts, the Flinders resistant line (FRL) rats. The functional consequences of this phenotypic difference on colonic mucosal function are not known. We sought to determine whether isolated distal...

journal_title：Experimental physiology

authors： Prior T,Hernandez J,Tougas G,Rangachari PK

更新日期：2004-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Our previous study demonstrates that elevated orexin 2 receptor (OX2R) activity within the rostral ventrolateral medulla (RVLM) contributes to hypertension in spontaneously hypertensive rats (SHRs), and a lower OX2R protein level was detected in their RVLM. The p...

journal_title：Experimental physiology

authors： Lee YH,Tsai MC,Li TL,Dai YW,Huang SC,Hwang LL

更新日期：2015-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the molecular underpinnings of seasonal metabolic plasticity during spring and autumn migrations in songbirds? What is the main finding and its importance? We report differences in mRNA levels of genes involved in the regulation of glucose and fat metabo...

journal_title：Experimental physiology

authors： Sharma A,Kumar V

更新日期：2019-12-01 00:00:00

abstract：:Plasticity of insulin secretion is essential to maintain the action of insulin during insulin resistance and to prevent diabetes. Investigation of the plasticity of insulin secretion and its regulation is challenging, and the objective of this study was to develop a novel large-animal-based model. The effect of chroni...

journal_title：Experimental physiology

authors： Gatford KL,De Blasio MJ,How TA,Harland ML,Summers-Pearce BL,Owens JA

更新日期：2012-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do the pulmonary vascular responses to hypoxia change during progressive exposure to high altitude and can alterations in these responses be related to changes in concentrations of circulating biomarkers that affect the pulmonary circulation? What is the main fin...

journal_title：Experimental physiology

authors： Luks AM,Levett D,Martin DS,Goss CH,Mitchell K,Fernandez BO,Feelisch M,Grocott MP,Swenson ER,Caudwell Xtreme Everest Investigators.

更新日期：2017-06-01 00:00:00

abstract：:The intrinsic proton buffering power (beta 1) of individual rat hippocampal and neocortical neurones maintained in culture has been investigated using the fluorescent dye 2', 7'-bis(carboxymethyl)-5, 6-(carboxyfluorescein) (BCECF). The steady-state intracellular pH (pH1) was estimated to be 7.03 +/- 0.04 (n = 22) in H...

journal_title：Experimental physiology

authors： Amos BJ,Richards CD

更新日期：1996-03-01 00:00:00

abstract：:Adenosine 5'-triphosphate (ATP) is a cotransmitter with classical transmitters in most nerves in the peripheral and central nervous systems, although the proportions vary between tissues and species and in different developmental and pathophysiological circumstances. There was early evidence that ATP was released toge...

journal_title：Experimental physiology

authors： Burnstock G

更新日期：2009-01-01 00:00:00

abstract：:In quiescent papillary muscles isolated from hearts of rats with streptozotocin-induced diabetes resting intracellular sodium activity (aiNa) was about 56% greater than in muscles from controls. An intracellular acid load induced by the NH4+ method caused a rise in aiNa whose maximum amplitude was similar in both grou...

journal_title：Experimental physiology

authors： Lagadic-Gossmann D,Feuvray D

更新日期：1991-01-01 00:00:00

abstract：:Experiments were performed to investigate, in the normal and acutely inflamed rabbit knee joint, the role of prostaglandins in the regulation of joint blood flow, measured by laser Doppler flowmetry, as well as their modulation of sympathetic vasoconstriction. Close intra-arterial injection of prostaglandin E2 (PGE2) ...

journal_title：Experimental physiology

authors： Najafipour H,Ferrell WR

更新日期：1994-01-01 00:00:00

abstract：UNLABELLED:The modulation of activity of the upper airway dilator and respiratory muscles plays a key role in the regulation of ventilation, but little is known about the link between their neuromuscular activation processes in vivo. This study investigated genioglossus and diaphragm responses to transcranial magnetic ...

journal_title：Experimental physiology

authors： Wang W,Similowski T,Sériès F

更新日期：2007-07-01 00:00:00

abstract：:The responses of afferent chemosensory fibres of the carotid body to individual chemostimuli have long been established. However, the mechanisms underlying the multiplicative interactions of these stimuli (i.e. how the combined effects of hypoxia and hypercapnia exert a greater effect on afferent nerve discharge than ...

journal_title：Experimental physiology

authors： Peers C

更新日期：2004-01-01 00:00:00

abstract：:Sympathetic baroreflex sensitivity is increased during selective activation of the skeletal muscle metaboreflex with postexercise ischaemia (PEI) in young adults. However, to date, there are no data demonstrating this neural interaction between the arterial baroreflex and the muscle metaboreflex in healthy older adult...

journal_title：Experimental physiology

authors： Greaney JL,Schwartz CE,Edwards DG,Fadel PJ,Farquhar WB

更新日期：2013-10-01 00:00:00

abstract：:In vivo microperfusion techniques were used to investigate the role of Na+-H+ exchange in the efferent ducts of the rat. Individual efferent ducts were perfused with a Krebs-Ringer bicarbonate solution (KRB) containing 0, 1, 3, 5 or 7.5 mM amiloride. Concentrations of 1-5 mM amiloride inhibited fluid reabsorption from...

journal_title：Experimental physiology

authors： Hansen LA,Clulow J,Jones RC

更新日期：1999-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We investigated whether 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) could prevent acute increases in body fat and changes in omental and subcutaneous adipose tissue following the sudden transition from physical activity to physical inactivity. ...

journal_title：Experimental physiology

authors： Ruegsegger GN,Sevage JA,Childs TE,Grigsby KB,Booth FW

更新日期：2017-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does blockade of the IL-6 receptor by tocilizumab inhibit immune cell mobilization to the blood stream in humans during an acute bout of exercise? What is the main finding and its importance? Blockade of IL-6 receptor signalling by tocilizumab attenuates mobiliza...

journal_title：Experimental physiology

authors： Bay ML,Heywood S,Wedell-Neergaard AS,Schauer T,Lehrskov LL,Christensen RH,Legård GE,Jensen PØ,Krogh-Madsen R,Ellingsgaard H

更新日期：2020-10-02 00:00:00