Abstract:
:Developmental dysphasia, a severe childhood learning disorder, is thought to result from problems in hemispheric specialization involving both left and right cerebral hemispheres. Regional cerebral blood flow (rCBF) was measured at rest and during stimulation of both hemispheres independently: dichotic listening for the left, dichaptic palpation for the right. Eight right-handed boys with expressive dysphasia, aged 8 to 12 years, were investigated using SPECT and compared with eight right-handed age-matched boys with Duchenne muscular dystrophy with reading disorders but normal speech. rCBF values at rest were also compared with those of five right-handed age-matched normal boys. In the dichotic task, children with dysphasia differed from children with dystrophia by failure to increase rCBF in the left hemisphere, in Broca's area, but rCBF increased in the right hemisphere, in the region homologous to Broca's area. In the dichaptic task, rCBF increased bilaterally for children with dysphasia whereas in children with dystrophia rCBF increased only in the right hemisphere. At rest the physiological asymmetry was reversed in favor of the right hemisphere in all areas except Broca's area. Surprisingly, the same applied at rest and for all areas in children with dystrophia. These results confirm that functional specialization of both hemispheres is impaired in developmental dysphasia. Moreover, they suggest that learning disabilities associated with Duchenne muscular dystrophy could also be related to abnormal hemispheric specialization.
journal_name
Dev Med Child Neuroljournal_title
Developmental medicine and child neurologyauthors
Chiron C,Pinton F,Masure MC,Duvelleroy-Hommet C,Leon F,Billard Cdoi
10.1017/s0012162299001139subject
Has Abstractpub_date
1999-08-01 00:00:00pages
512-20issue
8eissn
0012-1622issn
1469-8749journal_volume
41pub_type
杂志文章abstract::A survey of the population of the Spina Bifida Service (107 patients) of Georgetown University Hospital, Washington, D.C., and of a control population in the same hospital revealed that, although situated in an ethnically heterogeneous area, Service patients with a history of neural-tube defects in siblings or family ...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1975.tb03523.x
更新日期:1975-10-01 00:00:00
abstract::Fine motor skills are related to functioning in daily life and at school. We reviewed the status of knowledge, in preterm children, on the development of fine motor skills, the relation with gross motor skills, and risk factors for impaired fine motor skills. We searched the past 15 years in PubMed, using ['motor skil...
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doi:10.1017/s0012162299001279
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
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doi:10.1111/j.1469-8749.1984.tb04414.x
更新日期:1984-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1469-8749.1996.tb12084.x
更新日期:1996-02-01 00:00:00
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journal_title:Developmental medicine and child neurology
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
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更新日期:1990-06-01 00:00:00
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journal_title:Developmental medicine and child neurology
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