Synthesis of optically active NC-1800, a therapeutic agent for urinary disturbance.

Abstract:

:A new synthetic method for chiral oxazolidinone derivatives, therapeutic agents for treating urinary disturbance, is described. The condensed compound obtained from chiral 1-amino-3-phenyl-2-propanol and 1-phenyl-3-morpholino-1-propanone was reduced with Me4NBH(OAc)3 to give the intermediate, 1-(3-morpholino-1-phenylpropyl)amino-3-phenyl-2-propanol (MAPP) in 34% diastereomeric excess (d.e.). MAPP was converted to an urethane and purified by recrystallization of its methanesulfonate, to afford a single isomer, (2R)-1-[N-[(1S)-3-morpholino-1-phenylpropyl]-N -ethoxycarbonyl]amino-3-phenyl-2-propanol methanesulfonate (4-A. methanesulfonate).

authors

Yoshida S,Yamamoto M,Mochizuki N,Nohira H

doi

10.1248/cpb.47.1154

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

1154-6

issue

8

eissn

0009-2363

issn

1347-5223

journal_volume

47

pub_type

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