Abstract:
:According to traditional neurophysiological theory, consciousness requires neocortical functioning, and children born without cerebral hemispheres necessarily remain indefinitely in a developmental vegetative state. Four children between 5 and 17 years old are reported with congenital brain malformations involving total or near-total absence of cerebral cortex but who, nevertheless, possessed discriminative awareness: for example, distinguishing familiar from unfamiliar people and environments, social interaction, functional vision, orienting, musical preferences, appropriate affective responses, and associative learning. These abilities may reflect 'vertical' plasticity of brainstem and diencephalic structures. The relative rarity of manifest consciousness in congenitally decorticate children could be due largely to an inherent tendency of the label 'developmental vegetative state' to become a self-fulfilling prophecy.
journal_name
Dev Med Child Neuroljournal_title
Developmental medicine and child neurologyauthors
Shewmon DA,Holmes GL,Byrne PAdoi
10.1017/s0012162299000821subject
Has Abstractpub_date
1999-06-01 00:00:00pages
364-74issue
6eissn
0012-1622issn
1469-8749journal_volume
41pub_type
杂志文章abstract:AIM:Apolipoprotein E (APOE, protein; [ApoE, gene]) is a lipid transport protein abundantly present in brain cells. We investigated whether the APOE genotype is associated with cerebral palsy (CP) and whether patients with CP with comorbid conditions and more severe neurological deficits are likely to have a particular ...
journal_title:Developmental medicine and child neurology
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