Abstract:
:Clinical trials often assess therapeutic benefit on the basis of an event such as death or the diagnosis of disease. Usually, there are several additional longitudinal measures of clinical status which are collected to be used in the treatment comparison. This paper proposes a simple non-parametric test which combines a time to event measure and a longitudinal measure so that a substantial treatment difference on either of the measures will reject the null hypothesis. The test is applied on AIDS prophylaxis and paediatric trials.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Finkelstein DM,Schoenfeld DAdoi
10.1002/(sici)1097-0258(19990615)18:11<1341::aid-ssubject
Has Abstractpub_date
1999-06-15 00:00:00pages
1341-54issue
11eissn
0277-6715issn
1097-0258pii
10.1002/(SICI)1097-0258(19990615)18:11<1341::AID-Sjournal_volume
18pub_type
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