Complex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension.

Abstract:

:Anorectic agents, such as aminorex and fenfluramine derivatives, have been associated previously with the development of primary pulmonary hypertension. The combination diet drug phentermine-fenfluramine (or "phen-fen") was recently marketed in the United States. We describe a case of a 39-year-old woman with rapidly progressing, fatal pulmonary hypertension following administration of phentermine-fenfluramine. Autopsy was remarkable for complex pulmonary vascular lesions most consistent with thrombotic arteriopathy.

journal_name

Arch Pathol Lab Med

authors

Strother J,Fedullo P,Yi ES,Masliah E

doi

10.1043/0003-9985(1999)123<0539:CVLAAI>2.0.CO;2

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

539-40

issue

6

eissn

0003-9985

issn

1543-2165

journal_volume

123

pub_type

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