Abstract:
:The retinas of adult teleost fish can regenerate following injury, but little is known about the neuronal integration of the visual scene that is performed by the regenerated retina. Using goldfish retinal ganglion cells (RGCs) as the experimental system, an evaluation of dendritic arbor structure and passive electrotonic properties was developed, the aim being to quantitatively test the hypothesis that native and regenerated RGC dendritic arbors have similar structural and modeled electrotonic attributes. Fractal dimension was chosen as the descriptor of RGC dendritic arbor complexity, and the arbors' transfer function magnitudes were estimated using an electrically passive, equivalent-circuit analysis. For both native and regenerated RGCs, arbors qualitatively judged to be simple tended to have lower fractal dimension values than arbors judged to be more complex. All cells had similar cut-off frequencies, and for random stimulation of greater than 25% of an RGC's population of dendritic tips, there was a positive correlation between fractal dimension and transfer function magnitude. Some regenerated RGCs had abnormally long primary dendrites, but neither the distributions of fractal dimension values, nor the estimated transfer function magnitudes, were significantly different between native and regenerated RGCs. The results appear to support the hypothesis that structural and modeled electrotonic attributes of regenerated goldfish RGCs are similar to those of native RGCs, suggesting that regenerated RGCs may restore normal visual function.
journal_name
Vis Neuroscijournal_title
Visual neuroscienceauthors
Cameron DA,Vafai H,White JAdoi
10.1017/s0952523899162060subject
Has Abstractpub_date
1999-03-01 00:00:00pages
253-61issue
2eissn
0952-5238issn
1469-8714pii
S0952523899162060journal_volume
16pub_type
杂志文章abstract::Transgenic mice overexpressing bcl-2, due to inhibition of naturally occurring cell death, have much larger brains and optic nerves as compared to wild-type mice. Since developmental cell death is believed to exert a crucial role in establishing the mature neural circuitry and function, we asked the question of whethe...
journal_title:Visual neuroscience
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journal_title:Visual neuroscience
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800009524
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523899166100
更新日期:1999-11-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
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journal_title:Visual neuroscience
pub_type: 杂志文章
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journal_title:Visual neuroscience
pub_type: 杂志文章
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journal_title:Visual neuroscience
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更新日期:2005-03-01 00:00:00
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journal_title:Visual neuroscience
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doi:10.1017/s095252380000300x
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journal_title:Visual neuroscience
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doi:10.1017/s0952523800001152
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800010531
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523808080371
更新日期:2008-05-01 00:00:00
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journal_title:Visual neuroscience
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doi:10.1017/S0952523812000235
更新日期:2012-09-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523898146047
更新日期:1998-01-01 00:00:00
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journal_title:Visual neuroscience
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doi:10.1017/S0952523814000066
更新日期:2014-05-01 00:00:00
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journal_title:Visual neuroscience
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更新日期:1989-12-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800008312
更新日期:1995-05-01 00:00:00
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journal_title:Visual neuroscience
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doi:10.1017/s0952523804213256
更新日期:2004-05-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
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journal_title:Visual neuroscience
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更新日期:2011-01-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800001826
更新日期:1992-12-01 00:00:00
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journal_title:Visual neuroscience
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doi:10.1017/s0952523800000171
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/s0952523800005964
更新日期:1989-11-01 00:00:00
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journal_title:Visual neuroscience
pub_type: 杂志文章
doi:10.1017/S0952523809090014
更新日期:2009-01-01 00:00:00
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journal_title:Visual neuroscience
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journal_title:Visual neuroscience
pub_type: 杂志文章,评审
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journal_title:Visual neuroscience
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doi:10.1017/s0952523800003230
更新日期:1993-01-01 00:00:00