Abstract:
:The present article reviews the basic principles of a new approach to the characterization of pulmonary disease. This approach is based on the unique nuclear magnetic resonance (NMR) properties of the lung and combines experimental measurements (using specially developed NMR techniques) with theoretical simulations. The NMR signal from inflated lungs decays very rapidly compared with the signal from completely collapsed (airless) lungs. This phenomenon is due to the presence of internal magnetic field inhomogeneity produced by the alveolar air-tissue interface (because air and water have different magnetic susceptibilities). The air-tissue interface effects can be detected and quantified by magnetic resonance imaging (MRI) techniques using temporally symmetric and asymmetric spin-echo sequences. Theoretical models developed to explain the internal (tissue-induced) magnetic field inhomogeneity in aerated lungs predict the NMR lung behavior as a function of various technical and physiological factors (e.g., the level of lung inflation) and simulate the effects of various lung disorders (in particular, pulmonary edema) on this behavior. Good agreement has been observed between the predictions obtained from the mathematical models and the results of experimental NMR measurements in normal and diseased lungs. Our theoretical and experimental data have important pathophysiological and clinical implications, especially with respect to the characterization of acute lung disease (e.g., pulmonary edema) and the management of critically ill patients.
journal_name
Bioelectromagneticsjournal_title
Bioelectromagneticsauthors
Cutillo AG,Ailion DCdoi
10.1002/(sici)1521-186x(1999)20:4+<110::aid-bem13>subject
Has Abstractpub_date
1999-01-01 00:00:00pages
110-9eissn
0197-8462issn
1521-186Xjournal_volume
Suppl 4pub_type
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pub_type: 临床试验,杂志文章
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/(SICI)1521-186X(1996)17:6<436::AID-BEM2>3.
更新日期:1996-01-01 00:00:00
abstract::To investigate the ability of prokaryotic microorganisms to activate strategies in adapting themselves to the environmental stress induced by exposure to extremely low frequency electromagnetic fields (ELF-EMF), cultures of Escherichia coli ATCC 700926 exposed at 50 Hz EMF (0.1, 0.5, 1.0 mT), and the respective sham-e...
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pub_type: 杂志文章
doi:10.1002/bem.20391
更新日期:2008-05-01 00:00:00
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更新日期:2008-10-01 00:00:00
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journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/(sici)1521-186x(200004)21:3<197::aid-bem7>
更新日期:2000-04-01 00:00:00
abstract::The aim of the present study was to determine millimeter wave (MMW) absorption by blood vessels traversing the subcutaneous fat layer of murine skin. Most calculations were performed using the finite-difference time-domain (FDTD) technique. We used two types of models: (1) a rectangular block of multilayer tissue with...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:10.1002/bem.20658
更新日期:2011-09-01 00:00:00
abstract::We investigated the thermal distribution and cardiovascular effects produced by sustained exposure of rats to 94 GHz radio-frequency electromagnetic radiation (RFR). Sixteen ketamine-anesthetized Sprague-Dawley rats were exposed individually at a power density of 75 mW/cm2 under far-field conditions in E orientation. ...
journal_title:Bioelectromagnetics
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
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