Abstract:
OBJECTIVE:To determine the long term effects of antibiotic treatment for acute otitis media in young children. DESIGN:Prospective three year follow-up study within the framework of a primary care based, double blind, randomised, placebo controlled trial. SETTING:53 general practices in the Netherlands. PARTICIPANTS:168 children aged 6 months to 2 years with acute otitis media. INTERVENTIONS:Amoxicillin 40 mg/kg/day in three doses compared with placebo. MAIN OUTCOME MEASURES:Recurrence of acute otitis media; referral to secondary care; ear, nose, and throat surgery. RESULTS:Acute otitis media recurred in 63% (47/75) of children in the amoxicillin group and in 43% (37/86) of the placebo group (risk difference 20%, 95% confidence interval 5% to 35%); 30% (24/78 amoxicillin; 27/89 placebo) of children in both groups were referred to secondary care, and 21% (16/78) of the amoxicillin group compared with 30% (27/90) of the placebo group had ear, nose, and throat surgery (risk difference -9%, -23% to 4%). CONCLUSION:Recurrent acute otitis media occurred more often in the children originally treated with amoxicillin. This is another argument for judicious use of antibiotics in children with acute otitis media. Trial registration Netherlands Trial Register NTR1426.
journal_name
BMJjournal_title
BMJ (Clinical research ed.)authors
Bezáková N,Damoiseaux RA,Hoes AW,Schilder AG,Rovers MMdoi
10.1136/bmj.b2525subject
Has Abstractpub_date
2009-06-30 00:00:00pages
b2525eissn
0959-8138issn
1756-1833journal_volume
338pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:To identify additional factors, such as maternal age or factors related to previous reproductive outcome or family history, and the corresponding probability of carrying a chromosome abnormality in couples with two or more miscarriages. DESIGN:Nested case-control study. SETTING:Six centres for clinical gene...
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