Recurrence up to 3.5 years after antibiotic treatment of acute otitis media in very young Dutch children: survey of trial participants.

Abstract:

OBJECTIVE:To determine the long term effects of antibiotic treatment for acute otitis media in young children. DESIGN:Prospective three year follow-up study within the framework of a primary care based, double blind, randomised, placebo controlled trial. SETTING:53 general practices in the Netherlands. PARTICIPANTS:168 children aged 6 months to 2 years with acute otitis media. INTERVENTIONS:Amoxicillin 40 mg/kg/day in three doses compared with placebo. MAIN OUTCOME MEASURES:Recurrence of acute otitis media; referral to secondary care; ear, nose, and throat surgery. RESULTS:Acute otitis media recurred in 63% (47/75) of children in the amoxicillin group and in 43% (37/86) of the placebo group (risk difference 20%, 95% confidence interval 5% to 35%); 30% (24/78 amoxicillin; 27/89 placebo) of children in both groups were referred to secondary care, and 21% (16/78) of the amoxicillin group compared with 30% (27/90) of the placebo group had ear, nose, and throat surgery (risk difference -9%, -23% to 4%). CONCLUSION:Recurrent acute otitis media occurred more often in the children originally treated with amoxicillin. This is another argument for judicious use of antibiotics in children with acute otitis media. Trial registration Netherlands Trial Register NTR1426.

journal_name

BMJ

authors

Bezáková N,Damoiseaux RA,Hoes AW,Schilder AG,Rovers MM

doi

10.1136/bmj.b2525

subject

Has Abstract

pub_date

2009-06-30 00:00:00

pages

b2525

eissn

0959-8138

issn

1756-1833

journal_volume

338

pub_type

杂志文章,多中心研究,随机对照试验
  • Selective chromosome analysis in couples with two or more miscarriages: case-control study.

    abstract:OBJECTIVE:To identify additional factors, such as maternal age or factors related to previous reproductive outcome or family history, and the corresponding probability of carrying a chromosome abnormality in couples with two or more miscarriages. DESIGN:Nested case-control study. SETTING:Six centres for clinical gene...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.38498.669595.8F

    authors: Franssen MT,Korevaar JC,Leschot NJ,Bossuyt PM,Knegt AC,Gerssen-Schoorl KB,Wouters CH,Hansson KB,Hochstenbach R,Madan K,van der Veen F,Goddijn M

    更新日期:2005-07-16 00:00:00

  • Accuracy of UK Rapid Test Consortium (UK-RTC) "AbC-19 Rapid Test" for detection of previous SARS-CoV-2 infection in key workers: test accuracy study.

    abstract:OBJECTIVE:To assess the accuracy of the AbC-19 Rapid Test lateral flow immunoassay for the detection of previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. DESIGN:Test accuracy study. SETTING:Laboratory based evaluation. PARTICIPANTS:2847 key workers (healthcare staff, fire and rescue of...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.m4262

    authors: Mulchandani R,Jones HE,Taylor-Phillips S,Shute J,Perry K,Jamarani S,Brooks T,Charlett A,Hickman M,Oliver I,Kaptoge S,Danesh J,Di Angelantonio E,Ades AE,Wyllie DH,EDSAB-HOME and COMPARE Investigators.

    更新日期:2020-11-11 00:00:00

  • Prophylaxis and follow-up after possible exposure to HIV, hepatitis B virus, and hepatitis C virus outside hospital: evaluation of policy 2000-3.

    abstract:PROBLEM:Prophylactic treatment and follow-up after exposure to HIV, hepatitis B, and hepatitis C outside hospital needs to be improved. BACKGROUND AND SETTING:Until January 2000, people in Amsterdam could report exposure outside hospital to either a hospital or the municipal health service. If they reported to the mun...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.330.7495.825

    authors: Sonder GJ,Regez RM,Brinkman K,Prins JM,Mulder JW,Spaargaren J,Coutinho RA,van den Hoek A

    更新日期:2005-04-09 00:00:00

  • Primary and secondary prevention with new oral anticoagulant drugs for stroke prevention in atrial fibrillation: indirect comparison analysis.

    abstract:OBJECTIVE:To do an indirect comparison analysis of apixaban against dabigatran etexilate (2 doses) and rivaroxaban (1 dose), as well as of rivaroxaban against dabigatranetexilate (2 doses), for their relative efficacy and safety against each other, with particular focus on the secondary prevention population for stroke...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e7097

    authors: Rasmussen LH,Larsen TB,Graungaard T,Skjøth F,Lip GY

    更新日期:2012-11-05 00:00:00

  • Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies.

    abstract:OBJECTIVES:To assess the effects of treatments for non-metastatic invasive squamous cell carcinoma (SCC) of the skin using evidence from observational studies, given the paucity of evidence from randomised controlled trials. DESIGN:Systematic review of observational studies. DATA SOURCES:Medline, Embase, to December ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.f6153

    authors: Lansbury L,Bath-Hextall F,Perkins W,Stanton W,Leonardi-Bee J

    更新日期:2013-11-04 00:00:00

  • Screening for carriers of cystic fibrosis--a general practitioner's perspective.

    abstract::The identification of the gene for cystic fibrosis has led to the possibility of population based screening for carriers of cystic fibrosis to identify couples at risk of having an affected child. Pilot studies have shown that screening is feasible and does not cause untoward anxiety, though the uptake of testing vari...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.307.6908.849

    authors: Modell M

    更新日期:1993-10-02 00:00:00

  • Prevalence of antibodies to hepatitis B, hepatitis C, and HIV and risk factors in entrants to Irish prisons: a national cross sectional survey.

    abstract:OBJECTIVES:To determine the prevalence of antibodies to hepatitis B core antigen, hepatitis C virus, and HIV in entrants to Irish prisons and to examine risk factors for infection. DESIGN:Cross sectional, anonymous survey, with self completed risk factor questionnaire and oral fluid specimen for antibody testing. SET...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.323.7323.1209

    authors: Long J,Allwright S,Barry J,Reynolds SR,Thornton L,Bradley F,Parry JV

    更新日期:2001-11-24 00:00:00

  • Renal cell carcinoma.

    abstract::The treatment of renal cell carcinoma (RCC) has changed greatly over the past 15 years. Progress in the surgical management of the primary tumor and increased understanding of the molecular biology and genomics of the disease have led to the development of new therapeutic agents. The management of the primary tumor ha...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.g4797

    authors: Jonasch E,Gao J,Rathmell WK

    更新日期:2014-11-10 00:00:00

  • Treatment of and mortality from diabetic renal failure in patients identified in the 1985 United Kingdom survey. Joint Working Party on Diabetic Renal Failure of the British Diabetic Association, Renal Association, and the Research Unit of the Royal Colle

    abstract::The aim of the study was to determine the outcome in 181 diabetic patients with advanced, previously untreated renal impairment who had been identified in a survey conducted in six health regions in the United Kingdom in 1985. Late in 1987 questionnaires were sent to the consultant physicians, geriatricians, and nephr...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6708.1135

    authors:

    更新日期:1989-11-04 00:00:00

  • Differences in mortality after fracture of hip: the east Anglian audit.

    abstract:OBJECTIVE:To investigate differences between hospitals in clinical management of patients admitted with fractured hip and to relate these to mortality at 90 days. DESIGN:A prospective audit of process and outcome of care based on interviews with patients, abstraction from records with standard proforma, and follow up ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.310.6984.904

    authors: Todd CJ,Freeman CJ,Camilleri-Ferrante C,Palmer CR,Hyder A,Laxton CE,Parker MJ,Payne BV,Rushton N

    更新日期:1995-04-08 00:00:00

  • Effect of perioperative beta blockade in patients with diabetes undergoing major non-cardiac surgery: randomised placebo controlled, blinded multicentre trial.

    abstract:OBJECTIVES:To evaluate the long term effects of perioperative beta blockade on mortality and cardiac morbidity in patients with diabetes undergoing major non-cardiac surgery. DESIGN:Randomised placebo controlled and blinded multicentre trial. Analyses were by intention to treat. SETTING:University anaesthesia and sur...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.332.7556.1482

    authors: Juul AB,Wetterslev J,Gluud C,Kofoed-Enevoldsen A,Jensen G,Callesen T,Nørgaard P,Fruergaard K,Bestle M,Vedelsdal R,Miran A,Jacobsen J,Roed J,Mortensen MB,Jørgensen L,Jørgensen J,Rovsing ML,Petersen PL,Pott F,Haas M,

    更新日期:2006-06-24 00:00:00

  • Improving immunisation coverage in rural India: clustered randomised controlled evaluation of immunisation campaigns with and without incentives.

    abstract:OBJECTIVE:To assess the efficacy of modest non-financial incentives on immunisation rates in children aged 1-3 and to compare it with the effect of only improving the reliability of the supply of services. DESIGN:Clustered randomised controlled study. SETTING:Rural Rajasthan, India. PARTICIPANTS:1640 children aged 1...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.c2220

    authors: Banerjee AV,Duflo E,Glennerster R,Kothari D

    更新日期:2010-05-17 00:00:00

  • Sexual lifestyle of long distance lorry drivers in India: questionnaire survey.

    abstract::This article presents a study on the sexual lifestyle of long distance lorry drivers in India. Using a questionnaire survey method, a total of 5709 consecutive long distance lorry drivers were interviewed by three trained investigators between March 1994 and August 1994. Results showed that 87% (4949 men) of subject...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.318.7177.162

    authors: Rao KS,Pilli RD,Rao AS,Chalam PS

    更新日期:1999-01-16 00:00:00

  • Amblyopia treatment outcomes after screening before or at age 3 years: follow up from randomised trial.

    abstract:OBJECTIVE:To assess the effectiveness of early treatment for amblyopia in children. DESIGN:Follow up of outcomes of treatment for amblyopia in a randomised controlled trial comparing intensive orthoptic screening at 8, 12, 18, 25, 31, and 37 months (intensive group) with orthoptic screening at 37 months only (control ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.324.7353.1549

    authors: Williams C,Northstone K,Harrad RA,Sparrow JM,Harvey I,ALSPAC Study Team.

    更新日期:2002-06-29 00:00:00

  • Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study.

    abstract:OBJECTIVE:To determine if trimethoprim use for urinary tract infection (UTI) is associated with an increased risk of acute kidney injury, hyperkalaemia, or sudden death in the general population. DESIGN:Cohort study. SETTING:UK electronic primary care records from practices contributing to the Clinical Practice Resea...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.k341

    authors: Crellin E,Mansfield KE,Leyrat C,Nitsch D,Douglas IJ,Root A,Williamson E,Smeeth L,Tomlinson LA

    更新日期:2018-02-09 00:00:00

  • Eradication of methicillin resistant Staphylococcus aureus by "ring fencing" of elective orthopaedic beds.

    abstract:PROBLEM:Deep infection after joint arthroplasty can be catastrophic, leading to further surgery, loss of the prosthesis, disability, and risk of mortality. Twenty nine new cases of methicillin resistant Staphylococcus aureus occurred in the first year after elective orthopaedic surgery was centralised to a district gen...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.329.7458.149

    authors: Biant LC,Teare EL,Williams WW,Tuite JD

    更新日期:2004-07-17 00:00:00

  • Performance of alternative strategies for primary cervical cancer screening in sub-Saharan Africa: systematic review and meta-analysis of diagnostic test accuracy studies.

    abstract:OBJECTIVE:To assess and compare the accuracy of visual inspection with acetic acid (VIA), visual inspection with Lugol's iodine (VILI), and human papillomavirus (HPV) testing as alternative standalone methods for primary cervical cancer screening in sub-Saharan Africa. DESIGN:Systematic review and meta-analysis of dia...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.h3084

    authors: Fokom-Domgue J,Combescure C,Fokom-Defo V,Tebeu PM,Vassilakos P,Kengne AP,Petignat P

    更新日期:2015-07-03 00:00:00

  • The views of singlehanded general practitioners: a qualitative study.

    abstract:OBJECTIVES:To examine the concerns of singlehanded general practitioners working in an inner London area and to compare the views of general practitioners in partnerships. DESIGN:Qualitative analysis of semistructured interviews with a random sample of singlehanded general practitioners and a sample of general practit...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.307.6904.607

    authors: Green JM

    更新日期:1993-09-04 00:00:00

  • Use of inhaled corticosteroids during pregnancy and risk of pregnancy induced hypertension: nested case-control study.

    abstract:OBJECTIVE:To determine whether the use of inhaled corticosteroids during pregnancy increases the risk of pregnancy induced hypertension and pre-eclampsia among asthmatic women. DESIGN:Nested case-control study. SETTING:Three administrative health databases from Quebec: RAMQ, MED-ECHO, and Fichier des evenements demog...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38313.624352.8F

    authors: Martel MJ,Rey E,Beauchesne MF,Perreault S,Lefebvre G,Forget A,Blais L

    更新日期:2005-01-29 00:00:00

  • Overprescription of cholera vaccine to travellers by general practitioners.

    abstract::A questionnaire describing five hypothetical patients intending to travel to different countries was sent to 113 general practitioners, who were asked to state which patients they would recommend cholera vaccination to. The response rate was 80%. The general practitioners' recommendations were compared with those of t...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.300.6716.25

    authors: Mott A,Kinnersley P

    更新日期:1990-01-06 00:00:00

  • Commodes: inconvenient conveniences.

    abstract:OBJECTIVES:To investigate use of commodes and attitudes of users and carers to them. DESIGN:Interview with semi-structured questionnaire of subjects supplied with commodes from Leeds community appliance centre. SUBJECTS:140 users of a commode and 105 of their carers. RESULTS:Main reasons for being supplied with a co...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.307.6914.1258

    authors: Naylor JR,Mulley GP

    更新日期:1993-11-13 00:00:00

  • Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine inse

    abstract:OBJECTIVES:To compare the effectiveness of in vitro fertilisation with single embryo transfer or in vitro fertilisation in a modified natural cycle with that of intrauterine insemination with controlled ovarian hyperstimulation in terms of a healthy child. DESIGN:Multicentre, open label, three arm, parallel group, ran...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.g7771

    authors: Bensdorp AJ,Tjon-Kon-Fat RI,Bossuyt PM,Koks CA,Oosterhuis GJ,Hoek A,Hompes PG,Broekmans FJ,Verhoeve HR,de Bruin JP,van Golde R,Repping S,Cohlen BJ,Lambers MD,van Bommel PF,Slappendel E,Perquin D,Smeenk JM,Pelinck MJ,

    更新日期:2015-01-09 00:00:00

  • Prevention of acute knee injuries in adolescent female football players: cluster randomised controlled trial.

    abstract:OBJECTIVE:To evaluate the effectiveness of neuromuscular training in reducing the rate of acute knee injury in adolescent female football players. DESIGN:Stratified cluster randomised controlled trial with clubs as the unit of randomisation. SETTING:230 Swedish football clubs (121 in the intervention group, 109 in th...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.e3042

    authors: Waldén M,Atroshi I,Magnusson H,Wagner P,Hägglund M

    更新日期:2012-05-03 00:00:00

  • Cardiovascular mortality in Dutch men during 1996 European football championship: longitudinal population study.

    abstract:OBJECTIVE:To investigate whether an important football match increases stress to such an extent that it triggers acute myocardial infarction and stroke. DESIGN:Longitudinal study of mortality around 22 June 1996 (the day the Dutch football team was eliminated from the European football championship). Mortality on 22 J...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.321.7276.1552

    authors: Witte DR,Bots ML,Hoes AW,Grobbee DE

    更新日期:2000-12-23 00:00:00

  • Preventing iron deficiency in preschool children by implementing an educational and screening programme in an inner city practice.

    abstract:OBJECTIVE:To assess the feasibility and acceptability of screening young children for iron deficiency in a deprived inner city practice and to assess the effects of a programme of dietary education. DESIGN:Prospective study of children in general practice, comparison with historical controls. SETTING:A deprived inner...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6703.838

    authors: James J,Lawson P,Male P,Oakhill A

    更新日期:1989-09-30 00:00:00

  • Presentation of continuous outcomes in randomised trials: an observational study.

    abstract:OBJECTIVE:To characterise the percentage of available outcome data being presented in reports of randomised clinical trials with continuous outcome measures, thereby determining the potential for incomplete reporting bias. DESIGN:Descriptive cross sectional study. DATA SOURCES:A random sample of 200 randomised trials...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e8486

    authors: Schriger DL,Savage DF,Altman DG

    更新日期:2012-12-18 00:00:00

  • Income inequality and 30 day outcomes after acute myocardial infarction, heart failure, and pneumonia: retrospective cohort study.

    abstract:OBJECTIVES:To examine the association between income inequality and the risk of mortality and readmission within 30 days of hospitalization. DESIGN:Retrospective cohort study of Medicare beneficiaries in the United States. Hierarchical, logistic regression models were developed to estimate the association between inco...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.f521

    authors: Lindenauer PK,Lagu T,Rothberg MB,Avrunin J,Pekow PS,Wang Y,Krumholz HM

    更新日期:2013-02-14 00:00:00

  • Audit of compliance with antenatal protocols.

    abstract:OBJECTIVE:To assess the implementation of action protocols dictated by antenatal risk factors noted at the initial (booking) antenatal visit. DESIGN:Retrospective study of 2000 women delivered between 1 March 1990 and 29 March 1991. SETTING:Maternity department of a district general hospital supporting a multiethnic ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.305.6863.1184

    authors: Yoong AF,Lim J,Hudson CN,Chard T

    更新日期:1992-11-14 00:00:00

  • Use of non-orthodox and conventional health care in Great Britain.

    abstract:OBJECTIVE:To describe the characteristics of patients using non-orthodox health care and their pattern of use of conventional health care with respect to a particular problem. DESIGN:Postal survey of all 2152 practitioners of acupuncture, chiropractic, homeopathy, naturopathy, and osteopathy identified from 11 nationa...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.302.6770.207

    authors: Thomas KJ,Carr J,Westlake L,Williams BT

    更新日期:1991-01-26 00:00:00

  • Randomised trial of personalised computer based information for cancer patients.

    abstract:OBJECTIVE:To compare the use and effect of a computer based information system for cancer patients that is personalised using each patient's medical record with a system providing only general information and with information provided in booklets. DESIGN:Randomised trial with three groups. Data collected at start of r...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.319.7219.1241

    authors: Jones R,Pearson J,McGregor S,Cawsey AJ,Barrett A,Craig N,Atkinson JM,Gilmour WH,McEwen J

    更新日期:1999-11-06 00:00:00