The age of patients with thyrotoxicosis factitia in Italy from 1973 to 1996.

Abstract:

:Thyrotoxicosis factitia, a syndrome due to the surreptitious ingestion of excess thyroid hormones, has generally been diagnosed in young or middle-aged women with psychopathological disturbances. We reviewed all the cases seen at our Institution over a 24-yr period, from 1973 to 1996. All 25 patients were women. Analysis was restricted to 17 patients who were born and lived in Tuscany (our region), since only these patients were distributed during the whole observation period. Diagnosis of thyrotoxicosis factitia was based on the following parameters: elevated serum total and/or free thyroid hormone levels, undetectable serum thyrotropin levels, low/undetectable serum thyroglobulin concentration, normal urinary iodine excretion, low/suppressed thyroidal radioactive iodine uptake (RAIU), absence of goiter, absence of circulating anti-thyroid antibodies. Surreptitious ingestion of thyroid hormone pill was eventually admitted by all patients. Age at diagnosis was >50 yr in 7/17 patients (41%): 6 of them were distributed in the period 1995-1996, and one in 1988. Patients older than 60 yr were 5/17 (29%), all in the last two years of the period under investigation. There was an increase in the age of patients with thyrotoxicosis factitia (p=0.02), which lost a statistical significance when the patients of the 1995-1996 period were excluded from analysis (p=0.88). This study provides evidence of an increased age of patients with thyrotoxicosis factitia in more recent years. From a practical standpoint, our study suggests that thyrotoxicosis factitia should be suspected and adequately looked for even in old patients with thyrotoxicosis of inexplicable origin, especially in the absence of goiter and thyroid autoimmune phenomena, and when common causes of low-RAIU hyperthyroidism, such as a load with iodine-containing drugs or subacute thyroiditis, have been excluded.

journal_name

J Endocrinol Invest

authors

Bogazzi F,Bartalena L,Scarcello G,Campomori A,Rossi G,Martino E

doi

10.1007/BF03350892

keywords:

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

128-33

issue

2

eissn

0391-4097

issn

1720-8386

journal_volume

22

pub_type

杂志文章
  • In vitro detection of glycoprotein production and secretion by human nonfunctioning pituitary adenomas.

    abstract::This study, carried out on 9 nonfunctioning pituitary adenomas, was undertaken in order to evaluate the ability of these tumors to synthesize and release gonadotropins and/or free alpha-subunit (alpha-SU) of glycoproteins. The morphological study included electron microscopy and immunofluorescence analysis while hormo...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347659

    authors: Saccomanno K,Gil del Alamo P,Bassetti M,Reza-Elahi F,Spada A

    更新日期:1993-02-01 00:00:00

  • Bone turnover is reduced in children with juvenile rheumatoid arthritis.

    abstract::Juvenile Rheumatoid Arthritis (JRA) is frequently associated with osteoporosis. In order to determine if JRA osteoporosis is related to reduced formation or to increased bone resorption or both, serum levels of calcium (Ca), phosphorus (PO4), magnesium (Mg), alkaline phosphatase (ALP), parathormone (PTHi), 25-hydroxyv...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347283

    authors: Falcini F,Ermini M,Bagnoli F

    更新日期:1998-01-01 00:00:00

  • Treatment of pituitary macroadenomas secreting PRL, HGH or ACTH with long-acting bromocriptine.

    abstract::Long-acting im bromocriptine was administered to 7 patients with pituitary macroadenomas (4 acromegalics, 1 Nelson's syndrome and 2 prolactinomas), with good tolerance except during the first 24 h. During a 42-day period hormonal, CT-scan and visual field variations were followed. In acromegalics HGH decrease was not ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348130

    authors: Halperin I,Rodriguez MD,Cardenal C,Casamitjana R,Martinez Osaba MJ,Lienas V,Vilardell E

    更新日期:1987-06-01 00:00:00

  • Effects of starvation on pituitary and plasma growth hormone in rats.

    abstract::The present experiments were undertaken to study the effect of complete food removal on body weight, pituitary growth hormone (GH), plasma GH and glucose concentration in male and female Wistar rats. Plasma and pituitary GH levels were measured by means of a specific radioimmunoassay. Plasma glucose concentration decr...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349417

    authors: Gonzalez C,Jolin T

    更新日期:1981-01-01 00:00:00

  • Hypothyroidism in the "Arnolfini Portrait" (1434) by Jan Van Eyck (1390-1441).

    abstract:BACKGROUND:The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art. PURPOSE:The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these req...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-017-0751-6

    authors: Ashrafian H

    更新日期:2018-01-01 00:00:00

  • GH replacement therapy and second neoplasms in adult survivors of childhood cancer: a retrospective study from a single institution.

    abstract:PURPOSE:Growth hormone deficiency (GHD) is the most common endocrine late effect observed in childhood cancer survivors (CCS) previously submitted to cranial irradiation. Radiation therapy can also increase the risk of second neoplasms (SNs). Since in previous studies GH replacement therapy was associated with increase...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-014-0179-1

    authors: Brignardello E,Felicetti F,Castiglione A,Fortunati N,Matarazzo P,Biasin E,Sacerdote C,Ricardi U,Fagioli F,Corrias A,Arvat E

    更新日期:2015-02-01 00:00:00

  • Central hypothyroidism and growth hormone treatment: clinical care.

    abstract::Central hypothyroidism (CH) is a rare cause of hypothyroidism characterized by a defect of thyroid hormone production due to an insufficient TSH stimulation. CH can be congenital in the case of genetic defects or acquired in the case of lesions affecting either pituitary or hypothalamus. Diagnosis is usually made on a...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Lania A,Giavoli C,Ferrante E,Beck-Peccoz P

    更新日期:2008-09-01 00:00:00

  • Spying on organelle Ca²⁺ in living cells: the mitochondrial point of view.

    abstract::Over the past years, the use of genetically encoded Ca(2+) indicators (GECIs), derived from aequorin and green fluorescent protein, has profoundly transformed the study of Ca(2+) homeostasis in living cells leading to novel insights into functional aspects of Ca(2+) signalling. Particularly relevant for a deeper under...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-014-0178-2

    authors: Pendin D,Greotti E,Filadi R,Pozzan T

    更新日期:2015-01-01 00:00:00

  • Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects.

    abstract::Reportedly, the responsiveness of somatotrope cells to GHRH is reduced in elderly humans but it is totally restored by arginine (ARG) which likely acts by inhibiting hypothalamic release of somatostatin. As this effect was observed after infusion of high doses of the amino acid, in this study, we compared the effect o...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03347695

    authors: Ghigo E,Ceda GP,Valcavi R,Goffi S,Zini M,Mucci M,Valenti G,Cocchi D,Müller EE,Camanni F

    更新日期:1994-02-01 00:00:00

  • Thyroid nodule recurrence following lobo-isthmectomy: incidence, patient's characteristics, and risk factors.

    abstract:PURPOSE:This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors ass...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-018-0946-5

    authors: Zatelli MC,Lamartina L,Meringolo D,Arvat E,Damiani L,Grani G,Nervo A,Durante C,Giacomelli L

    更新日期:2018-12-01 00:00:00

  • Thyroid hormone inhibition of intermediary metabolism in dog thyroid slices stimulated by different agonists.

    abstract::The role of thyroid hormones in a short loop feedback in the thyroid is controversial. This process was studied in dog thyroid slices stimulated by TSH, carbachol and phorbol esters. Incubation of thyroid slices with T3 and T4 for 1 hour inhibited the subsequent stimulation of glucose oxidation induced by carbachol an...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347936

    authors: Pasquali D,Bellastella A,Field JB

    更新日期:1991-11-01 00:00:00

  • Development of diabetic nephropathy in nude mice.

    abstract:BACKGROUND:Immune dysfunction is very common in diabetes mellitus (DM). However, there is no evidence whether such immune dysfunction can influence the development of DM, especially the development of diabetic nephropathy (DN). AIM:To investigate the influence of absence of T cells on DN. MATERIALS AND METHODS:Balb/c...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8962

    authors: Lin S,Xu PC,Huang QE,Jia JY,Jia ZH,Wei L,Zheng ZF,Shang WY

    更新日期:2013-12-01 00:00:00

  • Mutations of LH and FSH receptors.

    abstract::Gonadotropins control male and female gonadal function by acting through specific receptors. The recent description of several mutations in LH and FSH receptors has significantly improved our understanding of the pathophysiology of several sexual disorder. Both gain- and loss-of-function germline mutations leading to ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03343777

    authors: Beck-Peccoz P,Romoli R,Persani L

    更新日期:2000-10-01 00:00:00

  • Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms.

    abstract::The pathogenesis of human obesity is the result of dysregulation of the reciprocal relationship between food intake and energy expenditure (EE), which influences daily energy balance and ultimately leads to weight gain. According to principles of energy homeostasis, a relatively lower EE in a setting of energy balance...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-017-0732-9

    authors: Piaggi P,Vinales KL,Basolo A,Santini F,Krakoff J

    更新日期:2018-01-01 00:00:00

  • Historical milestones in endocrinology.

    abstract::The 1865 volume of the "II Morgagni", one of the most important Italian medical journals of the 19th century, presented two important articles, milestones for further scientific studies in the field of sexual differentiation. One was the original description of the "ramified cells" of testicular tubules by E. Sertoli,...

    journal_title:Journal of endocrinological investigation

    pub_type: 历史文章,杂志文章

    doi:10.1007/BF03345329

    authors: Virdis R

    更新日期:2005-11-01 00:00:00

  • Cognitive functions and mood during chronic thyrotropin-suppressive therapy with L-thyroxine in patients with differentiated thyroid carcinoma.

    abstract:BACKGROUND:Subclinical thyroid dysfunctions may cause cognitive deficits and mood disorders. Chronic TSH-suppressive therapy with L-T(4) causing subclinical hyperthyroidism has been widely used in treatment of patients with thyroid differentiated carcinoma. The impact of this therapy on cognitive functions and mood hav...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8013

    authors: Jaracz J,Kucharska A,Rajewska-Rager A,Lacka K

    更新日期:2012-09-01 00:00:00

  • Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein.

    abstract:BACKGROUND:Thyroid gland is highly dependent on dietary intake of iodine for normal function, so it is particularly subjected to "endocrine disruptor" action. The human sodium/iodide symporter (hNIS) is an integral plasma membrane glycoprotein mediating the active transport of iodide into thyroid follicular cells, a cr...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347061

    authors: Agretti P,Dimida A,De Marco G,Ferrarini E,Rodrìguez Gonzàlez JC,Santini F,Vitti P,Pinchera A,Tonacchera M

    更新日期:2011-03-01 00:00:00

  • Indexes of abdominal adiposity in patients with type 2 diabetes.

    abstract:OBJECTIVE:To assess the relationship of waist circumference and weight/height ratio with height, and their association with components of the metabolic syndrome, in Type 2 diabetic patients. DESIGN:multicenter cross-sectional survey on a cohort enrolled in a prospective observational study. SUBJECTS:13,232 patients (...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,多中心研究

    doi:10.1007/BF03347475

    authors: Mannucci E,Alegiani SS,Monami M,Sarli E,Avogaro A,DAI (Diabetes and Informatics) Study Group.

    更新日期:2004-06-01 00:00:00

  • European collaborative study on luteinizing hormone assay: 2. Discrepancy among assay kits is related to variation both in standard curve calibration and epitope specificity of kit monoclonal antibodies.

    abstract::This report describes the results of the second part of the collaborative study organized by a working group sponsored by the Community Bureau of Reference of the European Community Commission. The whole study was designed to understand the causes of discrepancy among LH immunoassay methods. In the parent report we de...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF03347727

    authors: Costagliola S,Niccoli P,Florentino M,Carayon P

    更新日期:1994-06-01 00:00:00

  • Dietary fatty acids modify insulin secretion of rat pancreatic islet cells in vitro.

    abstract::The type of dietary fat affects the action of insulin by changes induced in the fatty acid composition of cell membranes. Little is known, however, about the effects of dietary fatty acids on insulin secretion or the possible relation between the fatty acid composition of the membrane phospholipids and insulin secreti...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03344034

    authors: Tinahones FJ,Pareja A,Soriguer FJ,Gómez-Zumaquero JM,Cardona F,Rojo-Martínez G

    更新日期:2002-05-01 00:00:00

  • Feminization as a result of both peripheral conversion of androgens and direct estrogen production from an adrenocortical carcinoma.

    abstract::A 45-year-old man presented with gynecomastia, hypertension and a large left adrenal mass. Further evaluation revealed elevated serum concentrations of estrogen, estrone sulfate, androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate, deoxycorticosterone, and aldosterone and increased 24-hour urinary ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348975

    authors: Zayed A,Stock JL,Liepman MK,Wollin M,Longcope C

    更新日期:1994-04-01 00:00:00

  • Silver-Russell syndrome and its genetic origins.

    abstract::Silver-Russell syndrome (SRS) is both clinically and genetically a heterogeneous congenital disorder. Patients are characterised by severe intrauterine and post-natal growth retardation, dysmorphic facial features and, asymmetry. Various chromosome abnormalities have been associated with the disease, involving most of...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Rossignol S

    更新日期:2006-01-01 00:00:00

  • Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system.

    abstract::Ghrelin is a 28-amino-acid hormone produced mainly by the stomach which strongly promotes food intake. It is the only known peripheral orexigenic hormone that induces the release of GH. Ghrelin has been proposed as a link between the enteric system and central regulation of energy balance and growth. Although it has r...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350806

    authors: Seoane LM,Al-Massadi O,Barreiro F,Dieguez C,Casanueva FF

    更新日期:2007-10-01 00:00:00

  • American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules.

    abstract::American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules are systematically developed statements to assist health care professionals in medical decision making for ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,实务指引

    doi:

    authors: Gharib H,Papini E,Paschke R,Duick DS,Valcavi R,Hegedüs L,Vitti P,AACE\/AME\/ETA Task Force on Thyroid Nodules.

    更新日期:2010-01-01 00:00:00

  • Glucose and insulin suppression of plasma free fatty acids in obese subjects with normal glucose tolerance or mild, newly diagnosed type 2 (non-insulin-dependent) diabetes.

    abstract::The in vivo suppressive effect of glucose and insulin on plasma free fatty acid concentrations was investigated in obese subjects with (n = 6) and without (n = 6) Type 2 (non-insulin-dependent) diabetes mellitus during a 4h-hyperglycemic glucose clamp (about 11.2 mmol/l). Somatostatin was infused (250 micrograms/h) du...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348582

    authors: Zancanaro C,Cigolini M,Bonora E,Moghetti P,Querena M,Muggeo M

    更新日期:1990-01-01 00:00:00

  • Resumption of menstruation and pituitary response to gonadotropin-releasing hormone in functional hypothalamic amenorrhea subjects undertaking estrogen replacement therapy.

    abstract:BACKGROUND:Functional hypothalamic amenorrhea (FHA) refers to a functional menstrual disorder with various causes and presentations. Recovery of menstrual cyclicity is common in long-term follow-up but the affecting factors remain unknown. AIM:To explore factors affecting the menstrual resumption and to evaluate the p...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/8939

    authors: Shen ZQ,Xu JJ,Lin JF

    更新日期:2013-11-01 00:00:00

  • Immunoreactive beta-endorphin levels in cerebrospinal fluid of children with acute lymphoblastic leukemia: relationship with glucocorticoid therapy and neurological complications.

    abstract::Neurological disorders, such as seizures, are not infrequently associated with anti-leukemic therapy. It has been hypothesized that a disrupted peptidergic transmission between neurons could be the cellular basis of the neurological dysfunction. Since endogenous opioids have been recently found to alter neuronal funct...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350022

    authors: Iannetti P,Fabbri A,Meloni G,Moleti ML,Ulisse S,Mandelli F,Isidori A,Imperato C

    更新日期:1989-10-01 00:00:00

  • Percutaneous intranodular ethanol injection: a new treatment for autonomous thyroid adenoma.

    abstract::Established methods for definitive ablation of autonomous thyroid nodules are surgery and radioiodine. Since it has been demonstrated that percutaneous ethanol injection can inactivate parathyroid adenomas and small hepatocellular carcinomas, we started a trial of this treatment in patients with autonomous thyroid nod...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348753

    authors: Paracchi A,Ferrari C,Livraghi T,Reschini E,Macchi RM,Bergonzi M,Raineri P

    更新日期:1992-05-01 00:00:00

  • The response of growth hormone and prolactin to oral diazepam in diabetics.

    abstract::We studied 8 insulin dependent stable young diabetics with a mean age of 20 yr. Each patient received 10 mg of diazepam orally after with drawing the baseline blood sample. Subsequent samples were obtained at 30 min intervals for 150 min. The oral administration of diazepam resulted in a significant increase in serum ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349471

    authors: Ajlouni K,El-Khateeb M,El-Zaheri MM,El-Najdawi A

    更新日期:1982-05-01 00:00:00

  • Reduced serum thyroglobulin response to bovine TSH in malignant hypofunctioning solid thyroid nodules: comparison to benign nodular disease.

    abstract::Forty-three euthyroid patients with a single, solid, nonfunctioning thyroid nodule were submitted to fine needle aspiration biopsy and serum thyroglobulin (Tg) was measured before and after (48h) 10 U of bovine TSH. Twenty-two normal subjects were also submitted to the bTSH test. Patients with nonfunctioning nodules w...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348125

    authors: Leite Z,Carneiro P,Halpern A,Medeiros-Neto G

    更新日期:1987-06-01 00:00:00