Abstract:
:Thyrotoxicosis factitia, a syndrome due to the surreptitious ingestion of excess thyroid hormones, has generally been diagnosed in young or middle-aged women with psychopathological disturbances. We reviewed all the cases seen at our Institution over a 24-yr period, from 1973 to 1996. All 25 patients were women. Analysis was restricted to 17 patients who were born and lived in Tuscany (our region), since only these patients were distributed during the whole observation period. Diagnosis of thyrotoxicosis factitia was based on the following parameters: elevated serum total and/or free thyroid hormone levels, undetectable serum thyrotropin levels, low/undetectable serum thyroglobulin concentration, normal urinary iodine excretion, low/suppressed thyroidal radioactive iodine uptake (RAIU), absence of goiter, absence of circulating anti-thyroid antibodies. Surreptitious ingestion of thyroid hormone pill was eventually admitted by all patients. Age at diagnosis was >50 yr in 7/17 patients (41%): 6 of them were distributed in the period 1995-1996, and one in 1988. Patients older than 60 yr were 5/17 (29%), all in the last two years of the period under investigation. There was an increase in the age of patients with thyrotoxicosis factitia (p=0.02), which lost a statistical significance when the patients of the 1995-1996 period were excluded from analysis (p=0.88). This study provides evidence of an increased age of patients with thyrotoxicosis factitia in more recent years. From a practical standpoint, our study suggests that thyrotoxicosis factitia should be suspected and adequately looked for even in old patients with thyrotoxicosis of inexplicable origin, especially in the absence of goiter and thyroid autoimmune phenomena, and when common causes of low-RAIU hyperthyroidism, such as a load with iodine-containing drugs or subacute thyroiditis, have been excluded.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Bogazzi F,Bartalena L,Scarcello G,Campomori A,Rossi G,Martino Edoi
10.1007/BF03350892keywords:
subject
Has Abstractpub_date
1999-02-01 00:00:00pages
128-33issue
2eissn
0391-4097issn
1720-8386journal_volume
22pub_type
杂志文章abstract:BACKGROUND/AIMS:Aldosterone and the mineralocorticoid receptor (MR) play a major role in sodium balance and blood pressure control. They are also involved in adipocyte metabolism. The aim of this study was to analyze the association between the MR p.I180V polymorphism with hypertension and markers of cardiovascular ris...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346627
更新日期:2010-07-01 00:00:00
abstract::Homocysteine (HCY) is a sulfur-containing amino acid involved in two metabolic pathways, catalized by cystathionine-B-synthase and methionine synthase, depending on vitamin (vit) B6, B12, and folate levels and enzymatic activity of methylenetetrahydrofolate. High HCY levels (HHCY) are associated with cardiovascular (C...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
abstract::Pituitary collision tumors are rare. They may create difficult diagnostic problems and their histogenesis is not clear. We report here an unusual case of a somatotroph adenoma colliding with a gonadotroph adenoma.The 64-year-old man had clinical acromegaly. His blood growth hormone level was elevated and magnetic reso...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03343674
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:An increased aggressiveness of familial papillary thyroid carcinoma (FPTC) compared with sporadic form has been reported. On the contrary, the biological behavior of familial microPTC (FmPTC) is still debated. To assess if familial diseases should be considered as a negative prognostic factor in mPTC, the clini...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-019-01039-0
更新日期:2019-10-01 00:00:00
abstract::Ketoacidosis is a metabolic alteration caused by absolute or relative insulin deficiency and oversecretion of glucagon. Prompt diagnosis and rapid initiation of treatment are mandatory to avoid the complications and fatal outcome. Reduction of plasma glucose to levels within acceptable limits, block of ketogenesis, re...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Traumatic brain injury (TBI) combined with fractures of long bones or large joints is often associated with enhanced osteogenesis (early fracture healing accompanied by hypertrophic callus formation and/or heterotopic ossifications). Humoral factors that cause enhanced osteogenesis in patients with TBI are not yet ide...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350319
更新日期:1998-02-01 00:00:00
abstract:AIM:In the last years there has been a progressive reduction of the average duration of sleep and an increase in the incidence of sleep disturbances. At the same time, an increase of the incidence of the metabolic syndrome has been described, partly attributable to the progressive worsening of dietary habits and the in...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40618-013-0016-y
更新日期:2014-02-01 00:00:00
abstract::Tumor-induced osteomalacia (TIO), also known as "oncogenic osteomalacia", is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to re...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.1007/s40618-018-0849-5
更新日期:2018-10-01 00:00:00
abstract::Testosterone therapy has been reported to be useful in the treatment of hypogonadism and partial androgen deficiency of the aging male (PADAM) syndrome. Testosterone administration is needed in order to maintain secondary sexual characteristics, muscle mass, bone mineral density, cognitive function and sexual drive. N...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
abstract::It has previously been suggested that ghrelin mediates GH-independent biologic activities on the heart. We investigated the acute effects on cardiac contraction of a single iv administration of human ghrelin (in a dose of 1 microg/kg) in severe untreated GH deficient subjects. Prior to the ghrelin infusion, an echocar...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/BF03347499
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors ass...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-018-0946-5
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:This study aimed to investigate the interactive effect of polycystic ovary syndrome (PCOS) status and obesity status on the serum levels of adipokines. METHODS:In this comparative case-control cross-sectional study, 58 women with PCOS and 104 eumenorrheic non-hirsute women as the control group were recruited. ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/s40618-017-0650-x
更新日期:2017-08-01 00:00:00
abstract::The authors report the results of a correlation study between the direct Immunobead Test (d-IBT) and other techniques for antisperm antibodies detection. The Gelatin Agglutination Test (GAT) and Tray Agglutination Test (TAT) were used to detect antibodies in blood serum and seminal plasma ("indirect methods"). The Dir...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346835
更新日期:1991-06-01 00:00:00
abstract:OBJECTIVE:Globalisation has extended to the kitchen and the Asian cuisine has gained international popularity with sushi and seaweed now being widespread. We explored the possible acute adverse effects of an iodine load from a single sushi-and-seaweed meal as seaweed iodine may induce thyroid dysfunction. METHODS:Nine...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s40618-019-01122-6
更新日期:2020-04-01 00:00:00
abstract::Somatomedin was measured by rat bioassay in samples obtained from renal artery and vein, in order to study the role of this organ in the production of somatomedin activity. The results showed a significant difference, with an increase of the activity in the venous samples. According to the data reported in the literat...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03350423
更新日期:1979-07-01 00:00:00
abstract::Cardiovascular problems have long been recognized as responsible for an increased morbidity and mortality in patients with acromegaly. The aim of the present study was to evaluate echocardiographically the prevalence of cardiomyopathy in a cohort of acromegalic patients and to analyze the results in relation to demogr...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03349779
更新日期:1995-09-01 00:00:00
abstract::Traumatic brain injury (TBI)-induced hypopituitarism remains a relevant medical problem, because it may affect a significant proportion of the population. In the last decade important studies have been published investigating pituitary dysfunction after TBI. Recently, a group of experts gathered and revisited the topi...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/7805
更新日期:2011-07-01 00:00:00
abstract::Pituitary metastases account for about 1% of operated pituitary lesions. Most derive from primaries in the breast or lung. Pituitary metastases from hepatocellular carcinoma (HCC) have rarely been reported. We describe a patient in whom headache and left external ophthalmoplegia were the only presenting signs of a cli...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347227
更新日期:2005-05-01 00:00:00
abstract::We evaluated the oral calcium-loading test (OCLT) in diagnosing normocalcemic primary hyperparathyroidism. Calcium and PTH levels were measured before, 60, 120 and 180 min after oral 1 g of calcium gluconolactate administration in 102 consecutive females with high circulating PTH levels, and 25 controls. Patients were...
journal_title:Journal of endocrinological investigation
pub_type: 临床试验,杂志文章
doi:10.1007/BF03345180
更新日期:2003-04-01 00:00:00
abstract::We hereby present a rare variant of multiple endocrine neoplasia type 2A (MEN2A) associated with a rare skin disease primary cutaneous lichen amyloidosis and discrete malignant pheochromocytoma in both adrenal glands and pancreatic tail, and interestingly accompanied ganglioneuroma located in retroperitoneum in a 34-y...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03347557
更新日期:2005-09-01 00:00:00
abstract::Growth hormone (GH) response to provocative tests was compared in normal short children. Seven of 23 children failed to respond to insulin hypoglycemia. Using insulin hypoglycemia followed by L-dopa only 2 of 23 children did not respond and giving bromocriptine combined with insulin hypoglycemia only 1 of 8 children f...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03351005
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Immune dysfunction is very common in diabetes mellitus (DM). However, there is no evidence whether such immune dysfunction can influence the development of DM, especially the development of diabetic nephropathy (DN). AIM:To investigate the influence of absence of T cells on DN. MATERIALS AND METHODS:Balb/c...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8962
更新日期:2013-12-01 00:00:00
abstract::During a systematic study of women with idiopathic galactorrhea, we observed several patients with normal random serum prolactin (PRL) levels and normal menses, but abnormal sellar tomograms characteristic of a pituitary adenoma. To test the hypothesis that these women might have intermittent PRL hypersecretion, we st...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348450
更新日期:1984-10-01 00:00:00
abstract::Androgens' metabolism and activity are gaining a more and more important role in human physiology particularly referring to aging and to neurodegenerative diseases. Androgen treatment is often required for long-lasting disorders. In order to improve their duration and effects, androgens can be administered as esters o...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/8655
更新日期:2013-06-01 00:00:00
abstract:INTRODUCTION:Interleukins and cytokines play an important role in the pathogenesis of many cancers.We aimed to evaluate the interleukin (IL)-6 gene polymorphisms in patients with papillary thyroid carcinoma (PTC) and control subjects. MATERIAL AND METHODS:In this study, 42 patients with PTC and 340 healthy controls we...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03346494
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Non-exercise activity thermogenesis has recently drawn attention because of its potential to prevent weight gain. AIM:This study evaluated the relationships between the duration of daily non-sedentary activities and the prevalence of metabolic syndrome and insulin resistance (IR) in the Japanese population....
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.3275/9066
更新日期:2013-12-01 00:00:00
abstract::Vitamin D via its receptor has essential actions on parathyroid cells, inhibiting PTH secretion, and parathyroid cell proliferation. While the effects of vitamin D depletion in the pathogenesis of secondary hyperparathyroidism in elderly individuals or in the occurrence of parathyroid hyperplasia in patients with rena...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:
更新日期:2011-07-01 00:00:00
abstract::Resveratrol, the naturally occurring polyphenolic compound characterized by anti-oxidative, anti-inflammatory and apoptotic properties, appears to contribute substantially to cardioprotection and cancer-prevention. In addition, resveratrol is believed to regulate several biological processes, mainly metabolism and agi...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章,评审
doi:10.3275/7926
更新日期:2011-11-01 00:00:00
abstract::Insulin degradation in IM-9 cultured human lymphocytes occurs extracellularly. In the presence of 0.1% bovine serum albumin, insulin degradation products are formed that are soluble in 5% trichloroacetic acid. In the presence of 5% bovine serum albumin, the major products of insulin degradation are insoluble in 5% tri...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348223
更新日期:1980-01-01 00:00:00
abstract::The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...
journal_title:Journal of endocrinological investigation
pub_type: 杂志文章
doi:10.1007/BF03348615
更新日期:1990-06-01 00:00:00