Abstract：
:Retinal ganglion cells (RGCs) undergo programmed cell death (apoptosis) after axonal injury. This cell death is mediated by several mechanisms, including deprivation of neurotrophic factors, alterations in gene expression, and production of reactive oxygen species. However, death of RGCs is delayed after axonal injury, and a significant number survive even after several days. This suggests that RGC death is not an immediate result of axonal injury, and that other pro-survival factors may play a role. While we and other researchers have focused on the mechanisms of cell death after axonal injury, it may be that determining the regulation of cell survival mechanisms may lead to innovative methods for neuroprotection. The final common pathway of glaucomatous optic neuropathy is RGC death, probably via damage to their axons occurring at or near the lamina cribrosa. Axonal injury leads directly (1) or indirectly (2) to the death of retinal ganglion cells. We and others have demonstrated that axotomy is associated with RGC apoptosis (3-7) as well as specific changes in expression of certain genes at the mRNA and protein level (8, 9). Reactive oxygen species may also be part of the pathway for RGC death (10, 11). We therefore hypothesize that axotomy leads to molecular events that are potentially destructive to RGCs, but also induces changes that are potentially protective against cellular injury. If this is the case, then RGC death from axonal injury would result not only from initiation of apoptosis, but also from failure of intrinsic neuroprotective mechanisms. It should therefore be theoretically possible to modulate these two classes of responses, and thus improve RGC cell survival after axotomy.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Levin LAsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
S12-6eissn
1120-6721issn
1724-6016journal_volume
9 Suppl 1pub_type
杂志文章,评审abstract：:The objectives of this study were two-fold: to identify tear histamine content and its relationship to changes in tear histaminase activity during the early (EPR) and late phases (LPR) of the allergic reaction induced by a conjunctival provocation test (CPT) and to evaluate the effects of lodoxamide on histamine relea...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-04-01 00:00:00
abstract：PURPOSE:To correlate conjunctival intercellular adhesion molecule 1 (ICAM-1) expression with cytologic and clinical findings of chronic graft-versus-host disease (GVHD). METHODS:Seven patients with chronic GVHD-related keratoconjunctivitis and five age-matched normal controls were recruited for the study. Clinical exa...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600104
更新日期：2006-01-01 00:00:00
abstract：:The changes in the cardiovascular system are associated with ocular manifestations, often as a consequence of pathological alteration in the ocular vasculature. The ease of visualization of these retinal changes makes the eye a window to the cardiovascular system. Certain congenital cardiac defects lead to changes in ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1177/1120672120914232
更新日期：2020-11-01 00:00:00
abstract：INTRODUCTION:Preretinal hemorrhages can be located in subhyaloid or sub-internal limiting membrane (ILM) space. Though optical coherence tomography (OCT) may help to distinguish the exact location of hemorrhage in selected cases, it is often difficult to discern clinically. The purpose is to describe a novel clinical s...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120934958
更新日期：2020-06-22 00:00:00
abstract：PURPOSE:To report a case series of anterior uveitis after Transepithelial Photorefractive Keratectomy (TransPRK) and determine its incidence, demographics and associated clinical features over a study period of 1 year. METHODS:This retrospective case series comprised of 200 eyes (100 patients) which underwent elective...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120974946
更新日期：2020-11-25 00:00:00
abstract：PURPOSE:To report a case of bilateral retinocytoma associated with calcified vitreous deposits. METHODS:Case report. RESULTS:On routine examination, a 35-year-old asymptomatic father of a child with bilateral retinoblastoma presented bilateral retinocytoma associated with vitreous calcifications, in the vicinity of t...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600227
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:To emphasize and create awareness of the possibility of inadvertently grafting an inverted corneal button and describe 4 cases that showed this phenomenon on human donor corneas during preservation and transportation from an eye bank. METHODS:Three out of 4 tissues showed inadvertent inversion during transport...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000711
更新日期：2016-02-15 00:00:00
abstract：:Two cases of idiopathic sclerochoroidal calcification are reported with follow-up of two and ten years. In addition we have reviewed 102 cases of choroidal osteoma, including six misleading case reports which actually described idiopathic sclerochoroidal calcification and not choroidal osteoma. Clinical manifestation ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：INTRODUCTION:Parinaud syndrome, caused by midbrain infarction, usually manifests as an ocular conjugate upgaze palsy. However, this sign should not point out straightforwardly to Parinaud syndrome, as other lesions in the central nervous system could cause it. CASE DESCRIPTION:The case of a 47-year-old woman showing a...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119855845
更新日期：2020-11-01 00:00:00
abstract：:Purpose. Extraocular muscle (EOM) pulleys are important in eye movement physiology and may play a role in the outcome of strabismus surgery. Few studies have evaluated "normal" position of EOM pulleys. We sought to assess intraoperatively medial rectus (MR) pulley location and variations in a prospective observational...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000187
更新日期：2013-01-21 00:00:00
abstract：PURPOSE:The imaging quality provided by a piggyback integrated by a monofocal intraocular lens (IOL) + a bifocal IOL of zero power and +3.75 diopters of addition is compared with the optics quality of a simple multifocal IOL of the same power and addition. METHODS:The imaging quality was evaluated by determining the m...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067211002000109
更新日期：2010-01-01 00:00:00
abstract：:Peripheral choroidal neovascularization can result in an elevated subretinal lesion which can simulate a choroidal tumor. We reviewed 8 eyes with 11 peripheral areas of subretinal fluid and exudate which were subsequently determined to be secondary to peripheral choroidal neovascularization. Previous reports of periph...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:To compare diagnostic capabilities and agreement between Oculus-Spark perimetry and 3 procedures of glaucoma morphologic analysis. METHODS:A total of 102 normal eyes and 104 consecutive eyes with suspected or confirmed glaucoma (1 eye per subject) were analyzed in a prospective observational case-control study...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000233
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:This prospective, randomized, double-masked, clinical trial was designed to evaluate visual acuity, contrast sensitivity, subjective quality of vision, and quality of life in 47 patients symmetrically, and randomly, implanted with 4 different IOL designs (SN6AD1, SN60D3, ReZoom NXG1, and Tecnis ZMA00), 3 months...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.5301/EJO.2011.8371
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of switching from bevacizumab to ranibizumab in patients with diabetic macular edema (DME). METHODS:This was a retrospective study of patients with DME initially treated with bevacizumab and switched to ranibizumab. Visual acuity (VA) and central retinal thickness (CRT) were retrieved ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000838
更新日期：2017-03-10 00:00:00
abstract：:Electroretinogram (ERG) changes with age have been studied widely, but there is no general agreement about the age at which ERG parameters reach adult values. We studied 296 eyes from 148 healthy subjects, divided into 14 age groups, ranging from 1 week to 21 years. Although most of the maturational changes or ERG tak...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Indocyanine green video-angiography (ICG) was done twice on three patients with choroidal osteoma. Choroidal osteoma consisted of two portions, a yellow-white area and a surrounding orange area. The early phase of ICG angiography showed hypofluorescence due to blockage, corresponding to the osteoma. However, the hypof...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：PURPOSE:This study aimed to assess details of therapy required to achieve an intraocular pressure (IOP) of ⩽12 mmHg in patients with severe glaucoma of different etiologies. METHODS:Patients with a follow-up of at least 1 year, who fulfilled inclusion criteria were selected, and data analyzed with respect to baseline ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120979903
更新日期：2020-12-08 00:00:00
abstract：PURPOSE:Avastin (bevacizumab) intravitreal injections are widely used for treatment of diabetic retinopathy. The aim of our study was to analyze effect of 1.25 mg of intravitreal Avastin on serum concentration of vascular endothelial growth factor (VEGF) in diabetic patients. METHODS:Participants were 10 diabetic pati...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000118
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:To evaluate optical coherence tomography (OCT) modifications of outer retinal layers as determinants for functional recovery after surgery for idiopathic macular hole (IMH). METHODS:This prospective study included 23 eyes of 23 consecutive patients who underwent vitreoretinal surgery for IMH. We excluded patie...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000905
更新日期：2017-03-10 00:00:00
abstract：:Wet age-related macular degeneration is a chronic condition culminating, in most cases, in blindness. The introduction of anti-angiogenic agents in 2006 has represented a major breakthrough in the treatment of the disease, but timely and effective treatment with regular follow-up and monitoring is mandatory to stabili...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1177/1120672120915685
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:Currently there is little information available about the corneal thickness values of healthy emmetropic subjects. Therefore, the authors decided to analyze the corneal thickness in healthy emmetropic subjects. METHODS:The authors analyzed the difference in thickness values between the thinnest corneal site an...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600207
更新日期：2006-03-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy and safety of needle revision and examine factors predictive of failure. METHODS:In total, 157 eyes of 131 patients that underwent needle revision augmented with either 5-fluorouracil or betamethasone for trabeculectomy failure were included in this retrospective study. Complete failur...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119830861
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:To present an unusual case of simultaneous bilateral retinal detachment (RD) following a coronary artery bypass graft in a patient with acute myocardial infarction (AMI). METHODS:A 78-year-old man was first seen for bilateral sudden visual loss after surgical treatment of AMI. The patient underwent ultrasound ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700530
更新日期：2007-09-01 00:00:00
abstract：PURPOSE:To evaluate the role of postoperative prone posturing for a single night in the outcome of trans pars plana vitrectomy (TPPV) with internal limiting membrane (ILM) peel and 20% perfluoroethane (C2F6) internal tamponade for idiopathic macular hole. METHODS:This prospective trial enrolled 14 eyes in 14 consecuti...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000039
更新日期：2012-05-01 00:00:00
abstract：:Purpose. To compare long-term variability of retinal nerve fiber layer thickness (RNFLT) measurements made with the RTVue-100 Fourier-domain optical coherence tomograph (RTVue-OCT) and scanning laser polarimetry with variable (GDx-VCC) and enhanced (GDx-ECC) corneal compensation. Methods. One eye each of 110 Caucasian...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000178
更新日期：2013-01-21 00:00:00
abstract：PURPOSE:Iridoschisis is a rare, bilateral condition, found in the elderly and connected with the coexistence of closed-angle glaucoma. Stromal atrophy or separation of the anterior from the posterior laminae with coexisting posterior synechiae are present. Phacoemulsification in eyes with a narrow pupil, unresponsive t...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000300
更新日期：2013-11-01 00:00:00
abstract：PURPOSE:To describe a case of multiorganism, drug-resistant keratitis that responded well to corneal crosslinking (CXL) treatment. METHODS:A 52-year-old man presented to our institute with a 2-month ocular history of infectious keratitis in his right eye, on topical antibacterial, antifungal, and antiprotozoan treatme...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000755
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of AcrySof SN60WF aspheric intraocular lens (IOL) in decreasing spherical aberration and total higher order aberrations (HOAs) after cataract surgery compared to the spherical SN60AT lens. METHODS:Wavefront analysis was conducted on 28 eyes of 28 patients that underwent un-complicated ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700307
更新日期：2007-05-01 00:00:00
abstract：:A 62-year-old female developed pseudophakic bullous keratopathy after cataract surgery and underwent Descemet stripping automated endothelial keratoplasty (DSAEK). Intraoperatively, a white opacified pre-Descemet's layer was noticed after scoring and removal of trypan blue stained Descemet's membrane (DM), and endothe...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120974271
更新日期：2020-11-30 00:00:00
