Abstract:
:To investigate the function of trichohyalin during terminal differentiation of the skin, immunohistochemical studies were performed on trichohyalin and its related proteins, filaggrin and involucrin, the components of the cornified cell envelope. In skin disorders unrelated to tumours, weak trichohyalin expression was found in a few granular cells or in the horny layer of psoriasis, ichthyosis, keratosis pilaris, porokeratosis, chronic dermatitis and callus. Similar trichohyalin expression was found in epidermal tumours, such as seborrheic keratosis, actinic keratosis, Bowen's disease and well-differentiated squamous cell carcinoma. In follicular tumours, trichohyalin expression was positive in trichoepithelioma, keratotic basal cell epithelioma, proliferating trichilemmal tumour, trichilemmoma, pilomatricoma and keratoacanthoma. From comparative studies with filaggrin and involucrin, trichohyalin expression was co-localized with them in molluscum contagiosum, keratoacanthoma and pilomatricoma. From this study, trichohyalin is revealed to have close functional relationship with other markers of terminal differentiation as a precursor of the cornified cell envelope of the skin.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Lee SC,Lee JB,Seo JJ,Kim YPdoi
10.1080/000155599750011336subject
Has Abstractpub_date
1999-03-01 00:00:00pages
122-6issue
2eissn
0001-5555issn
1651-2057journal_volume
79pub_type
杂志文章abstract::The possibility that topically-applied minoxidil might affect the growth cycle of hair follicles was studied in inbred Herston white mice and HRA/Skh1 hairless mice. In the normal follicular cycle, the anagen or growth phase can be followed by autoradiographic demonstration of [3H]thymidine uptake in proliferating mat...
journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
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journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/0001555575353356
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
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