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Relationship estimation by Markov-process models in a sib-pair linkage study.

Abstract：

:The results of sib-pair linkage studies may be compromised if a substantial number of putative sib pairs are not actually sib pairs. For classification of pairs in a sib-pair genome scan, I propose multipoint methods that are based on a Markov-process model of allele sharing along the chromosome. These methods can be implemented by standard algorithms that compute multipoint marker allele-sharing probabilities for sib pairs. When marker data from at least half the genome are used, misclassification rates are small. The methods will be implemented in an upcoming version of the computer software package S.A.G.E.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Olson JM

doi

10.1086/302360

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

1464-72

issue

5

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)62294-0

journal_volume

64

pub_type

杂志文章

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