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A worldwide assessment of the frequency of suicide, suicide attempts, or psychiatric hospitalization after predictive testing for Huntington disease.

Abstract：

:Prior to the implementation of predictive-testing programs for Huntington disease (HD), significant concern was raised concerning the likelihood of catastrophic events (CEs), particularly in those persons receiving an increased-risk result. We have investigated the frequency of CEs-that is, suicide, suicide attempt, and psychiatric hospitalization-after an HD predictive-testing result, through questionnaires sent to predictive-testing centers worldwide. A total of 44 persons (0.97%) in a cohort of 4,527 test participants had a CE: 5 successful suicides, 21 suicide attempts, and 18 hospitalizations for psychiatric reasons. All persons committing suicide had signs of HD, whereas 11 (52.4%) of 21 persons attempting suicide and 8 (44.4%) of 18 who had a psychiatric hospitalization were symptomatic. A total of 11 (84.6%) of 13 asymptomatic persons who experienced a CE during the first year after HD predictive testing received an increased-risk result. Factors associated with an increased risk of a CE included (a) a psychiatric history

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Almqvist EW,Bloch M,Brinkman R,Craufurd D,Hayden MR

doi

10.1086/302374

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

1293-304

issue

5

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)62274-5

journal_volume

64

pub_type

杂志文章,多中心研究

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