Anti-epiligrin cicatricial pemphigoid with IgG autoantibodies to the beta and gamma subunits of laminin 5.

Abstract:

:Anti-epiligrin cicatricial pemphigoid is an autoimmune subepithelial blistering disorder of mucous membranes and skin. By immunoblot analyses, sera of most patients with antiepiligrin cicatricial pemphigoid have been shown to react specifically with the alpha3 chain of laminin 5. We describe the first patient with anti-epiligrin cicatricial pemphigoid in whom circulating IgG autoantibodies directed against the beta3 and gamma2-chains of laminin 5 were detected. Treatment with oral prednisolone was beneficial in controlling the disease.

journal_name

J Am Acad Dermatol

authors

Fujimoto W,Toi Y,Okazaki F,Lazarova Z,Yancey KB,Arata J

doi

10.1016/s0190-9622(99)70453-6

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

637-9

issue

4

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(99)70453-6

journal_volume

40

pub_type

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