The effect of hyperbaric oxygen on medial collateral ligament healing in a rat model.

Abstract:

:Hyperbaric oxygen has been shown to promote healing in bone and some soft tissues. This study was undertaken to determine its effect on ligamentous healing. Forty-eight Sprague-Dawley rats underwent a standardized surgical laceration of the right (divided) medial collateral ligament, whereas the left (undivided) medial collateral ligament was not surgically lacerated. A control group of 24 rats recovered without intervention. An experimental group consisting of the other 24 rats was exposed to hyperbaric oxygen at 2.8 atmospheres for 1.5 hours a day for 5 days after the surgery. Six rats from each group were euthanized at 2, 4, 6, and 8 weeks. The stiffness and final force to failure were recorded for the divided and undivided medial collateral ligaments. At 4 weeks, a statistically greater force was required to cause failure of the previously divided ligaments that had been exposed to hyperbaric oxygen than those that had not. The stiffness and force to cause failure of previously divided ligaments were statistically greater at 4 weeks than at 2 weeks, whether or not hyperbaric oxygen was used. No additional statistical increases in stiffness or force were observed at 6 weeks.

journal_name

Clin Orthop Relat Res

authors

Horn PC,Webster DA,Amin HM,Mascia MF,Werner FW,Fortino MD

doi

10.1097/00003086-199903000-00028

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

238-42

issue

360

eissn

0009-921X

issn

1528-1132

pub_type

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