Abstract:
:The development of new gene delivery technologies is a prerequisite towards gene therapy clinical trials. Because gene delivery mediated by viral vectors remains of limited scope due to immunological and propagation risks, the development of new non-viral gene delivery systems is of crucial importance. We have synthesized a secondary library of mono-functionalized poly-(guanidinium)amines generated from a library of mono-functionalized polyamines applying the concept of "libraries from libraries." The method allows a quick and easy access to mono-functionalized geometrically varied poly-(guanidinium)amines. The new building blocks were introduced into cationic lipids to obtain novel poly-(guanidinium)amine lipids, which are potential DNA vectors for gene delivery.
journal_name
Biotechnol Bioengjournal_title
Biotechnology and bioengineeringauthors
Byk G,Soto J,Mattler C,Frederic M,Scherman Dsubject
Has Abstractpub_date
1998-04-01 00:00:00pages
81-7issue
2eissn
0006-3592issn
1097-0290pii
10.1002/(SICI)1097-0290(199821)61:2<81::AID-BIT1>3journal_volume
61pub_type
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