Oral immunization with a Streptococcal pneumoniae polysaccharide conjugate vaccine in enterocoated microparticles induces serum antibodies against type specific polysaccharides.

abstract：:Vaccines that could protect humans against the highly lethal Marburg and Ebola viruses have eluded scientists for decades. Classical approaches have been generally unsuccessful for Marburg and Ebola viruses and pose enormous safety concerns as well. Modern approaches, in particular those using vector-based approaches ...

journal_title：Vaccine

authors： Reed DS,Mohamadzadeh M

更新日期：2007-03-01 00:00:00

abstract：:Putative TB vaccine candidates were selected from lists of genes induced in response to in vivo-like stimuli, such as low oxygen and carbon starvation or growth in macrophages, and tested as plasmid DNA vaccines for their ability to protect against Mycobacterium tuberculosis challenge in a guinea pig aerosol infection...

journal_title：Vaccine

authors： Vipond J,Vipond R,Allen-Vercoe E,Clark SO,Hatch GJ,Gooch KE,Bacon J,Hampshire T,Shuttleworth H,Minton NP,Blake K,Williams A,Marsh PD

更新日期：2006-09-11 00:00:00

abstract：:Oral poliovirus vaccine (OPV) is tested for safety by evaluation of neurovirulence in rhesus and cynomolgus macaques. After intraspinal or intrathalamic injection of varying doses of vaccine, monkeys are followed for 17-21 days, killed, and a histopathological evaluation is made of the severity of poliomyelitis lesion...

journal_title：Vaccine

authors： Nathanson N,Horn SD

更新日期：1992-01-01 00:00:00

abstract：:Age-specific force of varicella infection, hospitalisation and death rates in non-immune persons were calculated using an age-based mathematical model and national data for France. A cost-effectiveness model was then applied to hypothetical cohorts of persons aged 15-45 years with a negative or uncertain history of va...

journal_title：Vaccine

authors： Hanslik T,Boëlle PY,Schwarzinger M,Carrat F,Freedberg KA,Valleron AJ,Flahault A

更新日期：2003-09-08 00:00:00

abstract：:CpG-DNA is currently attracting attention as an effective and safe vaccine adjuvant to prevent from microbial infections. In this report, we examined the effects of oligo B, which is a synthetic CpG-DNA, in mucosal administration of Bacillus Calmette-Guérin (BCG) and diphtheria toxoid (DT). Co-administration with olig...

journal_title：Vaccine

authors： Maeyama J,Komiya T,Takahashi M,Isaka M,Goto N,Yamamoto S

更新日期：2009-02-18 00:00:00

abstract：:Rubella is a mild disease characterized by low-grade fever, and a morbilliform rash, but causes congenital defects in neonates born from mothers who suffered from rubella during the pregnancy. After many passages of wild-type rubella virus strains in various types of cultured cells, five live attenuated rubella vaccin...

journal_title：Vaccine

authors： Otsuki N,Abo H,Kubota T,Mori Y,Umino Y,Okamoto K,Takeda M,Komase K

更新日期：2011-02-24 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) is still one of the most serious pathogens in cattle, meriting the development of improved vaccines. Recently, we developed a new adjuvant consisting of poly[di(sodium carboxylatoethylphenoxy)]-phosphazene (PCEP), either CpG ODN or poly(I:C), and an immune defense regulator (IDR) pep...

journal_title：Vaccine

authors： Snider M,Garg R,Brownlie R,van den Hurk JV,van Drunen Littel-van den Hurk S

更新日期：2014-11-28 00:00:00

abstract：:Genetic immunization holds promise as a vaccination method, but has so far proven ineffective in large primate and human trials. Herein, we examined the relative merits of genetic immunization and peptide immunization using bacteriophage λ. Bacteriophage λ has proven effective in immune challenge models using both imm...

journal_title：Vaccine

authors： Thomas BS,Nishikawa S,Ito K,Chopra P,Sharma N,Evans DH,Tyrrell DL,Bathe OF,Rancourt DE

更新日期：2012-02-01 00:00:00

abstract：:Effects of cholera toxin B subunits supplemented with 0.1% cholera toxin (CTB*) on systemic IgE antibody responses to ovalbumin (OVA) were examined in BDFI (H-2b/d), Balb/c (H-2d) and C3H (H-2k) mice given OVA intragastrically or intranasally. Two successive doses of OVA intragastrically administered to Balb/c and C3H...

journal_title：Vaccine

authors： Tamura S,Shoji Y,Hasiguchi K,Aizawa C,Kurata T

更新日期：1994-10-01 00:00:00

abstract：:DNA-mediated immunizations have been used to raise neutralizing antibodies for measles virus. Single inoculations of plasmids expressing measles hemagglutinin or fusion glycoproteins raised neutralizing antibody in BALB/c mice. Plasmids expressing the hemagglutinin glycoprotein (both normal and secreted) raised neutra...

journal_title：Vaccine

authors： Yang K,Mustafa F,Valsamakis A,Santoro JC,Griffin DE,Robinson HL

更新日期：1997-06-01 00:00:00

abstract：:Pneumococcal infection is a leading cause of adult morbidity and mortality in the United States. Immunization against this infection is a valuable strategy in preventive medicine. An effective pneumococcal vaccine has been available in this country for over a decade, but it remains poorly utilized. The purpose of the ...

journal_title：Vaccine

authors： Rushton TC,Ganguly R,Sinnott JT 4th,Banerji M

更新日期：1994-10-01 00:00:00

abstract：:All hospital discharges and deaths related to CAP and pneumococcal-pneumonia from adults over 50 from 2003 to 2007 in Spain were obtained. Among the 447,670 Pneumonia-all causes discharges 17% were pneumococcal pneumonia. The annual hospitalisation rate was 6.27 and 1.09 cases per 1000, respectively. 75,932 deaths for...

journal_title：Vaccine

authors： Gil-Prieto R,García-García L,Alvaro-Meca A,Méndez C,García A,de Miguel AG

更新日期：2011-01-10 00:00:00

abstract：BACKGROUND:Bacillus Calmette-Guérin (BCG) vaccination is a widely-used public health intervention for tuberculosis (TB) control. In Taiwan, like other intermediate TB burden settings, steadily declining TB incidence raises important questions on whether universal BCG vaccination should be discontinued. Recent surveys o...

journal_title：Vaccine

authors： Fu H,Lin HH,Hallett TB,Arinaminpathy N

更新日期：2018-09-18 00:00:00

abstract：:Racial differences in diarrheal disease have not been systematically examined, and the impact of rotavirus vaccine on these differences has not been assessed. We compared diarrhea-associated hospitalizations by race/ethnicity among children <5 years pre- (2000-2006) and post- (2007 and 2008) rotavirus vaccine introduc...

journal_title：Vaccine

authors： Yen C,Steiner CA,Barrett M,Curns AT,Hunter K,Wilson E,Parashar UD

更新日期：2010-10-28 00:00:00

abstract：:Enteropathogenic Escherichia coli (EPEC) is an important cause of diarrhea in children. EPEC adheres to the intestinal epithelium and causes attaching and effacing (A/E) lesions. Recombinant Mycobacterium smegmatis (Smeg) and Mycobacterium bovis BCG strains were constructed to express either BfpA or intimin. The entir...

journal_title：Vaccine

authors： Vasconcellos HL,Scaramuzzi K,Nascimento IP,Da Costa Ferreira JM Jr,Abe CM,Piazza RM,Kipnis A,Dias da Silva W

更新日期：2012-09-07 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. METHODS:We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospita...

journal_title：Vaccine

authors： Menniti-Ippolito F,Da Cas R,Traversa G,Santuccio C,Felicetti P,Tartaglia L,Trotta F,Di Pietro P,Barabino P,Renna S,Riceputi L,Tovo PA,Gabiano C,Urbino A,Baroero L,Le Serre D,Virano S,Perilongo G,Daverio M,Gnoato E,

更新日期：2014-07-31 00:00:00

abstract：:Prevention of lifestyle-related diseases and promotion of physical and mental well-being in adolescents require an understanding of how life situations place adolescents at risk. The most important risk factors for hepatitis B virus (HBV) infection are sexual activity with more than one partner and injecting drug use....

journal_title：Vaccine

authors： Meheus A

更新日期：2000-02-18 00:00:00

abstract：:Children in public care have poor health outcomes despite statutory health assessments. Incomplete immunisation of children entering the care system has been reported. Does this health disadvantage persist for those established in the care system? The immunisation status of 119 children in public care for at least 6 m...

journal_title：Vaccine

authors： Barnes P,Price L,Maddocks A,Cheung WY,Williams J,Jackson S,Mason B

更新日期：2005-04-15 00:00:00

abstract：:In this report, we describe a short peptide, containing a T helper- and a B-cell epitope, located in the Gag protein of the caprine arthritis encephalitis virus (CAEV). This T-cell epitope is capable of inducing a robust T-cell proliferative response in vaccinated goats with different genetic backgrounds and to provid...

journal_title：Vaccine

authors： Fluri A,Nenci C,Zahno ML,Vogt HR,Charan S,Busato A,Pancino G,Peterhans E,Obexer-Ruff G,Bertoni G

更新日期：2006-01-30 00:00:00

abstract：:The prevalence of hepatitis B virus (HBV) infection and its sequelae vary widely in the different populations living in the Asian-Pacific region. Horizontal transmission plays an important role in the spread of the disease; in East Asia, however, maternal transmission is particularly significant since a high portion o...

journal_title：Vaccine

authors： Sung JL

更新日期：1990-03-01 00:00:00

abstract：:In a 12-month cohort follow-up study of 2435 children vaccinated in 2007 by Statens Serum Institute BCG strain (BCG SSI, 17.8% had an adverse event (AE): erythema 12.4%, induration 12.2%, abscesses 2.5%, ulceration 0.9%, lymphadenitis 0.1%. The factors associated with a lower risk of AE were: age at vaccination <1 yea...

journal_title：Vaccine

authors： Dommergues MA,de La Rocque F,Guy C,Lécuyer A,Jacquet A,Guérin N,Fagot JP,Boucherat M,d'Athis P,Cohen R

更新日期：2009-11-23 00:00:00

abstract：:To identify Mycobacterium tuberculosis (Mtb) antigens as candidates for a subunit vaccine against tuberculosis (TB), we have employed a CD4+ T-cell expression screening method. Mtb-specific CD4+ T-cell lines from nine healthy PPD positive donors were stimulated with different antigenic substrates including autologous ...

journal_title：Vaccine

authors： Coler RN,Dillon DC,Skeiky YA,Kahn M,Orme IM,Lobet Y,Reed SG,Alderson MR

更新日期：2009-01-07 00:00:00

abstract：:Serological results obtained in a single laboratory from twin-studies on maternal immunisation, in Vietnam and Belgium offer the opportunity to compare antibody kinetics in infants before and after infant vaccination in the presence of vaccine-induced maternal antibodies. Nonlinear mixed-effects models (NLMMs) making ...

journal_title：Vaccine

authors： Tran TMP,Maertens K,Hoang HTT,Van Damme P,Leuridan E,Hens N

更新日期：2020-10-21 00:00:00

abstract：:The current total of AIDS cases in Mexico is 37,000 of which 86% have occurred in men. The major route of transmission is sexual. The campaign to prevent AIDS has fallen into four phases, and has now been extended to other sexually transmitted diseases, including hepatitis B. The first phase (1985-1989) was based arou...

journal_title：Vaccine

authors： Hernández Tepichin G

更新日期：2000-02-18 00:00:00

abstract：:A robust vaginal immune response is considered essential for an effective prophylactic vaccine that prevents transmission of HIV and other sexually acquired diseases. Considerable attention has recently focused on the potential of vaginally administered vaccines as a means to induce such local immunity. However, the p...

journal_title：Vaccine

authors： Pattani A,McKay PF,Curran RM,McCaffrey J,Gupta PN,Lowry D,Kett VL,Shattock RJ,McCarthy HO,Malcolm RK

更新日期：2012-04-05 00:00:00

abstract：BACKGROUND:Elimination of congenital rubella syndrome depends not only on effective childhood immunization but also on the identification and immunization of rubella susceptible women. We assessed rubella susceptibility among pregnant women and evaluated the adherence and response to postpartum immunization with measle...

journal_title：Vaccine

authors： Vilajeliu A,García-Basteiro AL,Valencia S,Barreales S,Oliveras L,Calvente V,Goncé A,Bayas JM

更新日期：2015-04-08 00:00:00

abstract：OBJECTIVES:With the re-emergence of chikungunya virus (CHIKV) in an explosive form and in the absence of a commercially available vaccine, we aimed to develop candidate vaccines employing recombinant E2 protein or chemically inactivated whole virus. DESIGN AND METHODS:E2 gene of CHIKV isolate of ECSA genotype was clon...

journal_title：Vaccine

authors： Kumar M,Sudeep AB,Arankalle VA

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:Recent guidance from related regulatory agencies and medical societies supports mandatory vaccination of healthcare workers (HCW) against influenza. At St. Jude Children's Research Hospital, a pediatric oncology referral center, more than 90% of HCWs receive vaccine each year without a policy mandating immun...

journal_title：Vaccine

authors： Hakim H,Gaur AH,McCullers JA

更新日期：2011-08-11 00:00:00

abstract：:Vaccination is considered the most cost-effective approach to preventing infectious diseases, yet better formulations and delivery methods for efficient distribution and administration of vaccines are needed, especially for low-resource settings. A fast-dissolving tablet (FDT) that could be packaged in a compact stack...

journal_title：Vaccine

authors： Lal M,Priddy S,Bourgeois L,Walker R,Pebley W,Brown J,Desai J,Darsley MJ,Kristensen D,Chen D

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Rotavirus infection mainly affects children under 5 years of age and causes 453,000 deaths annually throughout the world. Several countries in Latin America have introduced the rotavirus vaccine and the majority have epidemiological data to measure impact following vaccine introduction. OBJECTIVE:To asses...

journal_title：Vaccine

authors： De Oliveira LH,Giglio N,Ciapponi A,García Martí S,Kuperman M,Sanwogou NJ,Ruiz-Matus C,Marinho de Sousa MF

更新日期：2013-07-02 00:00:00