Route and type of nutrition influence mucosal immunity to bacterial pneumonia.

Abstract:

OBJECTIVE:To develop a model of established respiratory immunity against Pseudomonas aeruginosa pneumonia and to investigate the effects of route and type of nutrition on this immunity. SUMMARY BACKGROUND DATA:Diet influences the ability of gut-associated lymphoid tissue (GALT) to maintain mucosal immunity. Complex enteral diets and chow maintain normal GALT populations against established IgA-mediated antiviral respiratory immunity. Both intravenous and intragastric total parenteral nutrition (TPN) produce GALT atrophy, but only intragastric TPN preserves established antiviral immunity. The authors hypothesized that both GALT-depleting diets (intragastric and intravenous TPN) would impair immunity against bacterial pneumonia. METHODS:P. aeruginosa was administered intratracheally to determine the mortality rate at increasing doses, and liposomes containing P. aeruginosa antigens were used to generate effective respiratory immunization. In the final experiment, mice received liposomes containing P. aeruginosa antigens to establish immunity and then were randomized to chow, complex enteral diets, intragastric TPN, or intravenous TPN. After 5 days of diet, mice received live intratracheal P. aeruginosa, and the death rate was recorded at 24 and 48 hours. RESULTS:The LD50 and LD100 were 9 x 10(7) and 12 x 10(7), respectively. Immunization reduced the mortality rate from 66% to 12%. This immunization was maintained in mice fed chow or a complex enteral diet and was lost in animals receiving intravenous TPN. Intragastric TPN partially preserved this respiratory immunity. CONCLUSIONS:Protection against bacterial pneumonia can be induced by prior antigenic immunization. This protection is lost with intravenous TPN, partially preserved with a chemically defined enteral diet, and completely preserved with chow or complex enteral diets. Both route and type of nutrition influence antibacterial respiratory tract immunity.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

King BK,Kudsk KA,Li J,Wu Y,Renegar KB

doi

10.1097/00000658-199902000-00016

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

272-8

issue

2

eissn

0003-4932

issn

1528-1140

journal_volume

229

pub_type

杂志文章
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    doi:10.1097/SLA.0000000000001622

    authors: Bolckmans R,Himpens J

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    doi:10.1097/SLA.0b013e31825074f5

    authors: Shaw AD,Bagshaw SM,Goldstein SL,Scherer LA,Duan M,Schermer CR,Kellum JA

    更新日期:2012-05-01 00:00:00

  • The role of splenectomy in multimodality treatment of thrombotic thrombocytopenic purpura.

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    authors: Schneider PA,Rayner AA,Linker CA,Schuman MA,Liu ET,Hohn DC

    更新日期:1985-09-01 00:00:00

  • Virtual reality applied to hepatic surgery simulation: the next revolution.

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    journal_title:Annals of surgery

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    doi:10.1097/00000658-199811000-00001

    authors: Marescaux J,Clément JM,Tassetti V,Koehl C,Cotin S,Russier Y,Mutter D,Delingette H,Ayache N

    更新日期:1998-11-01 00:00:00

  • Permanent Pancreatic Duct Occlusion With Neoprene-based Glue Injection After Pancreatoduodenectomy at High Risk of Pancreatic Fistula: A Prospective Clinical Study.

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    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/SLA.0000000000003514

    authors: Mazzaferro V,Virdis M,Sposito C,Cotsoglou C,Droz Dit Busset M,Bongini M,Flores M,Prinzi N,Coppa J

    更新日期:2019-11-01 00:00:00

  • Abdominal gunshot wounds. An urban trauma center's experience with 300 consecutive patients.

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    authors: Feliciano DV,Burch JM,Spjut-Patrinely V,Mattox KL,Jordan GL Jr

    更新日期:1988-09-01 00:00:00

  • The role of tumor necrosis factor and nitric oxide in the acute cardiovascular response to endotoxin.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199601000-00009

    authors: Fahey TJ 3rd,Yoshioka T,Shires GT,Fantini GA

    更新日期:1996-01-01 00:00:00

  • Aggressive resection of metastatic disease in selected patients with malignant gastrinoma.

    abstract::Fifteen patients with Zollinger-Ellison syndrome followed at the National Institutes of Health with extensive metastatic disease had an actuarial 5-year survival of 20%. Therefore, in 1982 a prospective study to examine the effect and feasibility of removing all gross tumor in selected patients with extensive metastat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198604000-00003

    authors: Norton JA,Sugarbaker PH,Doppman JL,Wesley RA,Maton PN,Gardner JD,Jensen RT

    更新日期:1986-04-01 00:00:00

  • Splenic injury during resection for esophageal cancer: risk factors and consequences.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000650

    authors: Derogar M,Sadr-Azodi O,Lagergren P,Lagergren J

    更新日期:2015-01-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003984

    authors: Johari Y,Catchlove W,Tse M,Shaw K,Paul E,Chen R,Loh D,Packiyanathan A,Burton P,Nottle P,Ellis S,Brown W

    更新日期:2021-01-19 00:00:00

  • Molecules, cancer, and the surgeon. A review of molecular biology and its implications for surgical oncology.

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    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199007000-00002

    authors: Arbeit JM

    更新日期:1990-07-01 00:00:00

  • Hypothermic circulatory arrest for cerebral protection during combined carotid and cardiac surgery in patients with bilateral carotid artery disease.

    abstract:OBJECTIVE:The authors evaluated the protective effect of hypothermic circulatory arrest for patients with bilateral carotid artery disease who underwent cardiac surgical procedures. SUMMARY BACKGROUND DATA:Severe bilateral carotid artery disease coexisting with cardiac disease that requires surgical treatment is assoc...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199406000-00014

    authors: Kouchoukos NT,Daily BB,Wareing TH,Murphy SF

    更新日期:1994-06-01 00:00:00

  • Perforated stress ulcer in infants: a silent threat.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197912000-00006

    authors: Adeyemi SD,Ein SH,Simpson JS

    更新日期:1979-12-01 00:00:00

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    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0b013e31821fd1ce

    authors: Vlug MS,Wind J,Hollmann MW,Ubbink DT,Cense HA,Engel AF,Gerhards MF,van Wagensveld BA,van der Zaag ES,van Geloven AA,Sprangers MA,Cuesta MA,Bemelman WA,LAFA study group.

    更新日期:2011-12-01 00:00:00

  • Influence of Depression on Recovery After Major Noncardiac Surgery: A Prospective Cohort Study.

    abstract:OBJECTIVES:To determine the influence of patient depression (and anxiety) on postoperative outcome and surgeons' consideration of it. BACKGROUND:Patients' mental state influences the course of nonpsychiatric diseases. Evidence in the surgical setting comes mainly from cardiac-surgery patients and no predictive-model o...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001448

    authors: Orri M,Boleslawski E,Regimbeau JM,Barry C,Hassler C,Gregoire E,Bachellier P,Scatton O,Mabrut JY,Adham M,Vibert E,Revah-Levy A,Farges O

    更新日期:2015-11-01 00:00:00

  • The walk-in anergic patient. How best to assess the risk of sepsis following elective surgery.

    abstract::This prospective study evaluated host resistance in a surgical population who walked into the hospital for elective surgery. Patients were stratified into Hospital Reactive (HR, n = 19) if they reacted to two or more of five recall skin test antigens and Walk-in Anergic (WA, n = 26) if they did not react to the antige...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198404000-00011

    authors: Christou NV,Rode H,Larsen D,Loose L,Broadhead M,Meakins JL

    更新日期:1984-04-01 00:00:00

  • The effects of metoclopramide on postoperative ileus. A randomized double-blind study.

    abstract::Metoclopramide or placebo was administered postoperatively in a randomized, double-blind fashion to 115 patients undergoing laparotomy. The effect of metoclopramide on postoperative adynamic ileus (PAI) was evaluated. The patients were stratified into two groups: Group A--those with laparotomy without a gastrointestin...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197907000-00006

    authors: Davidson ED,Hersh T,Brinner RA,Barnett SM,Boyle LP

    更新日期:1979-07-01 00:00:00

  • Overestimation of hereditary breast cancer risk.

    abstract:OBJECTIVE:To find out how women with breast or ovarian cancer rate their chances of carrying hereditary factors for these cancers and to determine the extent to which they overestimate their risk. SUMMARY BACKGROUND DATA:BRCA1 and BRCA2 are genes that cause breast and ovarian cancer when they are inherited in families...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199809000-00010

    authors: Iglehart JD,Miron A,Rimer BK,Winer EP,Berry D,Shildkraut MJ

    更新日期:1998-09-01 00:00:00

  • Post-traumatic parotid fistulae and sialoceles. A prospective study of conservative management in 51 cases.

    abstract::The management of parotid sialoceles and fistulae have been unsatisfactory in the past, and numerous methods of treatment with varying success and morbidity have been described. The present prospective study reports results of conservative therapy in 51 patients over a 3-year period. In 50 patients, the injury healed ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198901000-00015

    authors: Parekh D,Glezerson G,Stewart M,Esser J,Lawson HH

    更新日期:1989-01-01 00:00:00

  • Variation in Bariatric Surgery Episode Costs in the Commercially Insured: Implications for Bundled Payments in the Private Sector.

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    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002462

    authors: Kelsall AC,Cassidy R,Ghaferi AA

    更新日期:2018-12-01 00:00:00

  • An aggressive surgical approach leads to improved survival in patients with gallbladder cancer: a 12-year study at a North American Center.

    abstract:OBJECTIVE:To determine if an aggressive surgical approach, with an increase in R0 resections, has resulted in improved survival for patients with gallbladder cancer. SUMMARY BACKGROUND DATA:Many physicians express a relatively nihilistic approach to the treatment of gallbladder cancer; consensus among surgeons regardi...

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    pub_type: 杂志文章

    doi:10.1097/01.sla.0000154118.07704.ef

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    更新日期:2005-03-01 00:00:00

  • Implications of Tumor Characteristics and Treatment Modality on Local Recurrence and Functional Outcomes in Children with Chest Wall Sarcoma: A Pediatric Surgical Oncology Research Collaborative Study.

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    pub_type: 杂志文章

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    更新日期:2020-11-04 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    authors: Genç CG,Jilesen AP,Partelli S,Falconi M,Muffatti F,van Kemenade FJ,van Eeden S,Verheij J,van Dieren S,van Eijck CHJ,Nieveen van Dijkum EJM

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    更新日期:1991-10-01 00:00:00

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    doi:10.1097/SLA.0000000000000642

    authors: Scatton O,Katsanos G,Boillot O,Goumard C,Bernard D,Stenard F,Perdigao F,Soubrane O

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    pub_type: 杂志文章

    doi:

    authors: Nyberg SL,Remmel RP,Mann HJ,Peshwa MV,Hu WS,Cerra FB

    更新日期:1994-07-01 00:00:00

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    更新日期:2009-08-01 00:00:00