Z and S mutations of the alpha1-antitrypsin gene and the risk of chronic obstructive pulmonary disease.

abstract：:Macrophages are the primary lung phagocyte and are instrumental in maintenance of a sterile, noninflamed microenvironment. IFNs are produced in response to bacterial and viral infection, and activate the macrophage to efficiently counteract and remove pathogenic invaders. Respiratory syncytial virus (RSV) inhibits IFN...

journal_title：American journal of respiratory cell and molecular biology

authors： Senft AP,Taylor RH,Lei W,Campbell SA,Tipper JL,Martinez MJ,Witt TL,Clay CC,Harrod KS

更新日期：2010-04-01 00:00:00

abstract：:The mTOR pathway is one of the key signal cascades in the pathogenesis of idiopathic pulmonary fibrosis. Previous studies have mainly focused on this pathway in the fibroblasts and/or myofibroblasts, but not in the epithelial cells. In this study, we sought to investigate the role of the mTOR pathway in lung epithelia...

journal_title：American journal of respiratory cell and molecular biology

authors： Saito M,Mitani A,Ishimori T,Miyashita N,Isago H,Mikami Y,Noguchi S,Tarui M,Nagase T

更新日期：2020-06-01 00:00:00

abstract：:Sarcoidosis is characterized by the accumulation of activated lymphocytes in the lungs and other organs and by the spontaneous production of the active form of vitamin D, calcitriol. We hypothesized that calcitriol may modulate the responsiveness of human lymphocytes to the relevant biologic mediator, interleukin-2 (I...

journal_title：American journal of respiratory cell and molecular biology

authors： Fraher LJ,Caveney AN,McFadden RG

更新日期：1995-06-01 00:00:00

abstract：:Isoprostanes are prostaglandin-like molecules that accumulate in oxidative stress and also exert powerful biological effects on a wide variety of tissues. We investigated the effects of several different isoprostanes on contractions evoked by electrical field stimulation (EFS) in bovine trachealis, finding only 15-E2t...

journal_title：American journal of respiratory cell and molecular biology

authors： Paredes C,Tazzeo T,Janssen LJ

更新日期：2007-12-01 00:00:00

abstract：:The application of conditional reprogramming culture (CRC) methods to nasal airway epithelial cells would allow more wide-spread incorporation of primary airway epithelial culture models into complex lung disease research. In this study, we adapted the CRC method to nasal airway epithelial cells, investigated the grow...

journal_title：American journal of respiratory cell and molecular biology

authors： Reynolds SD,Rios C,Wesolowska-Andersen A,Zhuang Y,Pinter M,Happoldt C,Hill CL,Lallier SW,Cosgrove GP,Solomon GM,Nichols DP,Seibold MA

更新日期：2016-09-01 00:00:00

abstract：:Airway epithelial cells produce a number of chemokines, including eotaxins. Among the three known eotaxins, T helper (Th) type 2 cytokines have been observed to induce the expression of eotaxin-3 mRNA. This study investigated the effect of interferon (IFN)-gamma, a Th1 cytokine, on Th2 cytokine-induced eotaxin-3 produ...

journal_title：American journal of respiratory cell and molecular biology

authors： Yamamoto S,Kobayashi I,Tsuji K,Nishi N,Muro E,Miyazaki M,Zaitsu M,Inada S,Ichimaru T,Hamasaki Y

更新日期：2004-10-01 00:00:00

abstract：:Integrins are heterodimeric cell-surface glycoproteins that mediate cell-cell and cell-matrix adhesion. We previously identified cDNA encoding a novel integrin beta subunit, beta 7, from bronchoalveolar lavage fluid (BALF) leukocytes. The beta 7 subunit protein is now known to associate with at least two integrin alph...

journal_title：American journal of respiratory cell and molecular biology

authors： Erle DJ,Brown T,Christian D,Aris R

更新日期：1994-03-01 00:00:00

abstract：:Pulmonary artery hypertension (PAH) is a rare and fatal disorder that involves extensive remodeling of the pulmonary arteries mediated by hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Aberrant platelet-derived growth factor (PDGF) activity can lead to hyperproliferation of PASMCs; however, littl...

journal_title：American journal of respiratory cell and molecular biology

authors： Chen J,Guo J,Cui X,Dai Y,Tang Z,Qu J,Raj JU,Hu Q,Gou D

更新日期：2018-02-01 00:00:00

abstract：:Latent cytomegalovirus (CMV) infection is often reactivated in the lung. We postulated that this reactivation could occur by stimulation of the CMV major immediate early (IE) promoter by other viruses that infect the lung. The specific aim of this study was to investigate whether adenovirus early proteins could stimul...

journal_title：American journal of respiratory cell and molecular biology

authors： Metcalf JP,Monick MM,Stinski MF,Hunninghake GW

更新日期：1994-04-01 00:00:00

abstract：:The etiology of acute lung injury is complex and associated with numerous, chemically diverse precipitating factors. During acute lung injury in mice, one key event is epithelial cell injury that leads to reduced surfactant biosynthesis. We have previously reported that transgenic mice that express transforming growth...

journal_title：American journal of respiratory cell and molecular biology

authors： Bein K,Wesselkamper SC,Liu X,Dietsch M,Majumder N,Concel VJ,Medvedovic M,Sartor MA,Henning LN,Venditto C,Borchers MT,Barchowsky A,Weaver TE,Tichelaar JW,Prows DR,Korfhagen TR,Hardie WD,Bachurski CJ,Leikauf GD

更新日期：2009-08-01 00:00:00

abstract：:The present study investigated mechanisms underlying apical and basolateral P2Y(1)-mediated Cl(-) secretion in human airway epithelial cells. Apical and basolateral ATP induced short-circuit currents (I(sc)) with different properties via P2Y(1) receptors. The former comprised an immediate rise followed by a slow atten...

journal_title：American journal of respiratory cell and molecular biology

authors： Son M,Ito Y,Sato S,Ishikawa T,Kondo M,Nakayama S,Shimokata K,Kume H

更新日期：2004-03-01 00:00:00

abstract：:The cystic fibrosis transmembrane conductance regulator (CFTR) serves a pivotal role in normal epithelial homeostasis; its absence leads to destruction of exocrine tissues, including those of the gastrointestinal tract and lung. Acute regulation of CFTR protein in response to environmental stimuli occurs at several le...

journal_title：American journal of respiratory cell and molecular biology

authors： Guimbellot JS,Fortenberry JA,Siegal GP,Moore B,Wen H,Venglarik C,Chen YF,Oparil S,Sorscher EJ,Hong JS

更新日期：2008-11-01 00:00:00

abstract：:Airway neutrophilia is a prominent feature of chronic obstructive pulmonary disease. As cigarette smoke (CS) and epidermal growth factor (EGF) both cause release of interleukin-8 (IL-8) from epithelial cells in vitro, we investigated whether autocrine ligands for the EGF receptor (EGFR) are involved in this proinflamm...

journal_title：American journal of respiratory cell and molecular biology

authors： Richter A,O'Donnell RA,Powell RM,Sanders MW,Holgate ST,Djukanović R,Davies DE

更新日期：2002-07-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases-3 (TIMP-3) has emerged as a key mediator of inflammation. Recently, we reported that the resolution of inflammation is impaired in Timp3(-/-) mice after bleomycin-induced lung injury. Here, we demonstrate that after LPS instillation (another model of acute lung injury), Timp3(-/-...

journal_title：American journal of respiratory cell and molecular biology

authors： Gill SE,Gharib SA,Bench EM,Sussman SW,Wang RT,Rims C,Birkland TP,Wang Y,Manicone AM,McGuire JK,Parks WC

更新日期：2013-11-01 00:00:00

abstract：:Pulmonary lymphangioleiomyomatosis (LAM), a disease of young women, is characterized by proliferation of immature-appearing smooth-muscle cells (LAM cells) in the lungs and abdomen. LAM cells react with monoclonal antibody HMB45, which recognizes a 100-kD glycoprotein (gp100) originally found in human melanoma cells. ...

journal_title：American journal of respiratory cell and molecular biology

authors： Matsumoto Y,Horiba K,Usuki J,Chu SC,Ferrans VJ,Moss J

更新日期：1999-09-01 00:00:00

abstract：:To investigate mechanisms regulating intra-alveolar coagulation, we studied monolayers of the A549 human lung epithelial cell line. The surface of A549 cells delayed the onset of prothrombin-to-thrombin conversion and prevented total prothrombin consumption in normal plasma compared to plastic cell-free wells. Similar...

journal_title：American journal of respiratory cell and molecular biology

authors： Berry L,Andrew M,Post M,Ofosu F,O'Brodovich H

更新日期：1991-04-01 00:00:00

abstract：:Interleukin (IL)-1beta stimulates the release of granulocyte macrophage colony-stimulating factor (GM-CSF) from lung epithelial cells. To investigate the molecular mechanisms underlying GM-CSF regulation, we studied GM-CSF production, messenger RNA (mRNA) expression levels, and GM-CSF promoter activity in A549 human a...

journal_title：American journal of respiratory cell and molecular biology

authors： Bergmann M,Barnes PJ,Newton R

更新日期：2000-05-01 00:00:00

abstract：:Activation of G protein-coupled receptor by dopamine and hypoxia-generated reactive oxygen species promote Na+,K+-ATPase endocytosis. This effect is clathrin dependent and involves the activation of protein kinase C (PKC)-zeta and phosphorylation of the Na+,K+-ATPase alpha-subunit. Because the incorporation of cargo i...

journal_title：American journal of respiratory cell and molecular biology

authors： Chen Z,Krmar RT,Dada L,Efendiev R,Leibiger IB,Pedemonte CH,Katz AI,Sznajder JI,Bertorello AM

更新日期：2006-07-01 00:00:00

abstract：:Retention kinetics for insoluble particles that deposit in the lung oftentimes resemble a multicomponent process during alveolar clearance, with each component appearing to follow simple first-order kinetics. Inasmuch as alveolar macrophages (AM) are thought to play an important role in particle removal from the lung,...

journal_title：American journal of respiratory cell and molecular biology

authors： Lehnert BE,Valdez YE,Tietjen GL

更新日期：1989-08-01 00:00:00

abstract：:In allergic airway diseases, intermediate progenitor cells (IPCs) increase in number in the surface epithelium. IPCs arise from basal cells, the origin of hallmark pathological changes, including goblet cell hyperplasia and mucus hypersecretion. Thus, targeting IPCs will benefit future treatment of allergic airway dis...

journal_title：American journal of respiratory cell and molecular biology

authors： Lee SN,Kim SJ,Yoon SA,Song JM,Ahn JS,Kim HC,Choi AMK,Yoon JH

更新日期：2020-12-02 00:00:00

abstract：:Lung development is associated with a surge in surfactant phosphatidylcholine (PC) production to prepare the newborn for extrauterine breathing. This process is associated with a marked increase in the activity of the rate-regulatory surfactant enzyme, CTP:phosphocholine cytidylyltransferase (CCTalpha). To investigate...

journal_title：American journal of respiratory cell and molecular biology

authors： McCoy DM,Fisher K,Robichaud J,Ryan AJ,Mallampalli RK

更新日期：2006-09-01 00:00:00

abstract：:Neutrophils were found to demonstrate chemotactic responses to pepsinized human placental type IV collagen and its purified aminoterminal 7S domain. The maximal chemotactic responses occur at approximately 400 ng/ml and approximately 30 ng/ml of type IV collagen and 7S collagen, respectively, and are similar in magnit...

journal_title：American journal of respiratory cell and molecular biology

authors： Senior RM,Hinek A,Griffin GL,Pipoly DJ,Crouch EC,Mecham RP

更新日期：1989-12-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMN) release gelatinase B in response to variable stimuli. Gelatinase B degrades basement membrane components in vitro, and inhibition of matrix metalloproteinase activity blunts PMN migration through a prototype basement membrane (Matrigel) and amnionic membranes. Accordingly, it has bee...

journal_title：American journal of respiratory cell and molecular biology

authors： Betsuyaku T,Shipley JM,Liu Z,Senior RM

更新日期：1999-06-01 00:00:00

abstract：:Although neutrophil migration from the systemic circulation involves the beta2- (or CD18) integrin family, the existence of an alternative, CD18-independent route of neutrophil extravasation to tissues has been demonstrated in animal models. The molecular interactions involved in this alternative migratory route have ...

journal_title：American journal of respiratory cell and molecular biology

authors： Mackarel AJ,Russell KJ,Brady CS,FitzGerald MX,O'Connor CM

更新日期：2000-08-01 00:00:00

abstract：:Recently, we described the isolation through fluorescent-activated cell sorting (FACS) of low autofluorescent (LAF) cells from human bronchoalveolar lavage (BAL). These LAF cells displayed an immunophenotype comparable with that of dendritic cells (DC), and showed a high potency to stimulate naive T cells. In the stud...

journal_title：American journal of respiratory cell and molecular biology

authors： van Haarst JM,Verhoeven GT,de Wit HJ,Hoogsteden HC,Debets R,Drexhage HA

更新日期：1996-12-01 00:00:00

abstract：:The precise role of each nitric oxide (NO) synthase (NOS) isoform in the pathobiology of asthma is not well established. Our objective was to investigate the contribution of constitutive NO synthase (cNOS) and inducible NOS (iNOS) isoforms to lung mechanics and inflammatory and remodeling responses in an experimental ...

journal_title：American journal of respiratory cell and molecular biology

authors： Prado CM,Leick-Maldonado EA,Yano L,Leme AS,Capelozzi VL,Martins MA,Tibério IF

更新日期：2006-10-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) can result in cell death or genetic alterations when cells are subjected to radiation, exposure to toxins, or other environmental stresses. A complex DNA-damage-response pathway is activated to repair the damage, and the inability to repair these breaks can lead to carcinogenesis. One o...

journal_title：American journal of respiratory cell and molecular biology

authors： Msiska Z,Pacurari M,Mishra A,Leonard SS,Castranova V,Vallyathan V

更新日期：2010-08-01 00:00:00

abstract：:Fetal airway smooth muscle contracts to neural stimulation from early gestation. This study aimed to document the development of the nerves and ganglia within the bronchial tree of the fetal pig lung as the structural correlates for this function. The formation of these structures during lung development (pseudoglandu...

journal_title：American journal of respiratory cell and molecular biology

authors： Weichselbaum M,Sparrow MP

更新日期：1999-11-01 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) is an allergic granulomatous interstitial lung disease resulting from a reaction of selected individuals to repeated inhalations of certain antigens. HP is characterized by chronic inflammation, and the development of the disease seems to be immunologically mediated. In farmer's lung,...

journal_title：American journal of respiratory cell and molecular biology

authors： Denis M,Cormier Y,Tardif J,Ghadirian E,Laviolette M

更新日期：1991-08-01 00:00:00

abstract：:Recently, investigators demonstrated associations between fine particulate matter (PM)-associated metals and adverse health effects. Residual oil fly ash (ROFA), a waste product of fossil fuel combustion from boilers, is rich in the transition metals Fe, Ni, and V, and when released as a fugitive particle, is an impor...

journal_title：American journal of respiratory cell and molecular biology

authors： Farraj AK,Hazari MS,Haykal-Coates N,Lamb C,Winsett DW,Ge Y,Ledbetter AD,Carll AP,Bruno M,Ghio A,Costa DL

更新日期：2011-02-01 00:00:00