Inhibition of lymphoproliferative response and its restoration with a glucan immunomodulator in mice with experimental larval toxocarosis.

Abstract:

:A high infective dose of Taxocara canis eggs (2,500 eggs per mouse) induced a partial immunosuppression in mice, manifested by inhibition of the proliferative response of splenic T and B cells to polyclonal activators. A glucan immunomodulator given to infected animals at the beginning of the experiment showed a marked stimulative and restorative effect on the parasite-suppressed lymphoproliferative response. The ability of T. canis to migrate in the host was reduced in glucan-treated animals by 27%.

journal_title

Folia microbiologica

authors

Borosková Z,Reiterová K,Dubinský P,Tomasovicová O,Machnicka B

doi

10.1007/BF02820794

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

475-6

issue

5

eissn

0015-5632

issn

1874-9356

journal_volume

43

pub_type

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