Porcine platelet von Willebrand antigen II (vW AgII): inhibitory effect on collagen-induced aggregation and comparative distribution with human platelets.

abstract：:Two candidate ECAA reference preparations have been calibrated in a multicentre exercise at 14 representative national laboratories to provide reference thromboplastin for a large field study in 16 European countries. Two preparations were required because of the established differences in ISI arising from the two mai...

journal_title：Thrombosis and haemostasis

authors： Poller L,Barrowcliffe TW,van den Besselaar AM,Jespersen J,Tripodi A,Houghton D

更新日期：1996-12-01 00:00:00

abstract：:Myocardial infarction results from a platelet-rich occlusive coronary thrombus. Platelet membrane glycoprotein IIb/IIIa plays an important role in platelet adhesion and aggregation. Two polymorphisms of the gene encoding the IIIa subunit. PLA1 and PLA2, have been identified. We investigated the frequency of these poly...

journal_title：Thrombosis and haemostasis

authors： Durante-Mangoni E,Davies GJ,Ahmed N,Ruggiero G,Tuddenham EG

更新日期：1998-08-01 00:00:00

abstract：:Staphylokinase (SAK) expresses plasminogen activator (PA) activity by forming a complex with plasmin. The interaction between the plasmin-SAK complex and plasminogen was investigated using synthesized peptides, which were constructed according to the amino acid sequence of the SAK molecule. A synthetic nonadecapeptide...

journal_title：Thrombosis and haemostasis

authors： Okada K,Ueshima S,Matsuno H,Kawao N,Okamoto C,Tanaka M,Matsuo O

更新日期：2007-05-01 00:00:00

abstract：:Abnormalities of Hageman factor dependent pathways have been described in a wide variety of human disease states. Congenital deficiencies of factor XII (Hageman trait) prekallikrein (Fletcher trait) and high molecular weight kininogen (Williams, Fitzgerald and Flaujeac traits) although resulting in profound in vitro c...

journal_title：Thrombosis and haemostasis

authors： Colman RW,Wong PY

更新日期：1977-12-15 00:00:00

abstract：:FPA level, fibrinogen turnover rate, and fibrinolytic activity were studied on 18 patients with malignant disease. It was found that the FPA levels were significantly elevated and were correlated with fibrinogen turnover rate (r = 0.74, p less than 0.001) and FDP (r - 0.58, p less than 0.02). Estimated FPA turnover ra...

journal_title：Thrombosis and haemostasis

authors： Yoda Y,Abe T

更新日期：1981-12-23 00:00:00

abstract：:Tissue factor-factor VIIa catalysed activation of factor IX is inhibited by the complex of tissue factor pathway inhibitor (TFPI) and factor Xa. At present, no information is available as to what extent the kinetics of complex formation between TFPI and factor Xa during factor X activation contribute to the overall ra...

journal_title：Thrombosis and haemostasis

authors： Lindhout T,Franssen J,Willems G

更新日期：1995-09-01 00:00:00

abstract：:When compared to normal megakaryocytes, those from a patient with the giant platelet syndrome exhibited numerous cytochemical abnormalities. These reflected disturbances in the metabolism of RNA, glycogen, arginine-rich histone, and various glycolytic enzymes. Ultrastructural studies of the abnormal megakaryocytes als...

journal_title：Thrombosis and haemostasis

authors： Kass L,Leichtman DA,Beals TF,Schnitzer B

更新日期：1977-10-31 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) evolution is unpredictable, and there is no therapy except surgery for patients with an aortic size> 5 cm (large AAA). We aimed to identify new potential biomarkers that could facilitate prognosis and treatment of patients with AAA. A differential quantitative proteomic analysis of plas...

journal_title：Thrombosis and haemostasis

authors： Burillo E,Lindholt JS,Molina-Sánchez P,Jorge I,Martinez-Pinna R,Blanco-Colio LM,Tarin C,Torres-Fonseca MM,Esteban M,Laustsen J,Ramos-Mozo P,Calvo E,Lopez JA,Vega de Ceniga M,Michel JB,Egido J,Andrés V,Vazquéz J,Meilha

更新日期：2015-06-01 00:00:00

abstract：:Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and is considered as an attractive drug target. We generated two different antibody fragments, an antigen-binding fragment (Fab) and a single-chain variable fragment (scFv), derived from three distinct monoclonal antibodies (MAs) that inhibit t...

journal_title：Thrombosis and haemostasis

authors： Develter J,Dewilde M,Gils A,Declerck PJ

更新日期：2009-07-01 00:00:00

abstract：:To assess the thrombotic risk of aprotinin in aortocoronary bypass surgery, we retrospectively analyzed the results of a trial, originally designed to compare the effects of one-year treatment with various antithrombotic drugs in the prevention of vein-graft occlusion. Graft patency at one year was assessed by angiogr...

journal_title：Thrombosis and haemostasis

authors： van der Meer J,Hillege HL,Ascoop CA,Dunselman PH,Mulder BJ,van Ommen GV,Pfisterer M,van Gilst WH,Lie KI

更新日期：1996-01-01 00:00:00

abstract：:The presence of lupus anticoagulant (LA) predisposes to fetal loss and to venous and arterial thrombosis; however, a subgroup of women is unaffected by pregnancy loss. Currently, no predictive markers are available for the identification of women positive for LA at increased risk for pregnancy loss. It was the aim of ...

journal_title：Thrombosis and haemostasis

authors： Sailer T,Zoghlami C,Kurz C,Rumpold H,Quehenberger P,Panzer S,Pabinger I

更新日期：2006-05-01 00:00:00

abstract：:The interaction of bovine platelets with bovine glomerular basement membrane has been studied by aggregometry, transmission and scanning electron microscopy and measurement of [3H] serotonin release. In the absence of added calcium platelets adhere to basement membrane but fail to undergo the release reaction or aggre...

journal_title：Thrombosis and haemostasis

authors： Davis JL,Chandler DK,Riquetti P,Rogers S,Kocan KM,Ownby CL,Hudson BG,Carraway KL

更新日期：1979-12-21 00:00:00

abstract：:High physiological concentrations of plasma vasopressin (aVP) when achieved by infusion cause an increase in plasma factor VIII coagulant activity and shortening of the euglobulin clot lysis time (ECLT). To investigate the effects of aVP on components of the fibrinolytic pathway and on thrombin generation, 9 healthy v...

journal_title：Thrombosis and haemostasis

authors： Hariman H,Grant PJ,Hughes JR,Booth NA,Davies JA,Prentice CR

更新日期：1989-04-25 00:00:00

abstract：:By the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (<5%). Evid...

journal_title：Thrombosis and haemostasis

authors： Hemker HC,Al Dieri R,De Smedt E,Béguin S

更新日期：2006-11-01 00:00:00

abstract：:Increased fibrinogen concentration is a well known phenomenon following acute ischemic stroke. However, the natural course of this hyperfibrinogenemia is uncertain. We aimed to clarify whether it is of a transient or more persistent nature in patients who harbor an underlying morbid biology of atherothrombo-inflammati...

journal_title：Thrombosis and haemostasis

authors： Shenhar-Tsarfaty S,Ben Assayag E,Bova I,Shopin L,Cohen M,Berliner S,Shapira I,Bornstein NM

更新日期：2008-01-01 00:00:00

abstract：:A fibrinolysis inhibitor was purified in serum from post-traumatic patients by the use of flat bed electrofocusing of serum desalted by gel chromatography followed by affinity chromatography on a column of matrix-linked plasminogen. Disc gel electrophoresis yielded one protein band. The inhibitor protein was also foun...

journal_title：Thrombosis and haemostasis

authors： Bagge L,Björk I,Saldeen T,Wallin R

更新日期：1978-02-28 00:00:00

abstract：:In hereditary angioedema (HAE), normal C1-inhibitor (C1-INH) is low and the contact system activated. Recently, the findings of a tissue factor mutant selectively deficient in promoting the conversion of FVII to FVIIa, but with retained cofactor for FVIIa, made it possible to examine reliably the pre-existing content ...

journal_title：Thrombosis and haemostasis

authors： Nielsen EW,Morrissey J,Olsen JO,Osterud B

更新日期：1995-10-01 00:00:00

abstract：:Existing clinical scores do not perform well in predicting bleeding in elderly patients with acute venous thromboembolism (VTE). We sought to derive an easy-to-use clinical score to help physicians identify elderly patients with VTE who are at high-risk of bleeding during extended anticoagulation (>3 months). Our deri...

journal_title：Thrombosis and haemostasis

authors： Seiler E,Limacher A,Mean M,Beer HJ,Osterwalder J,Frauchiger B,Righini M,Aschwanden M,Matter CM,Banyai M,Kucher N,Staub D,Lämmle B,Rodondi N,Squizzato A,Aujesky D

更新日期：2017-08-24 00:00:00

abstract：:The haematopoietic hormone erythropoietin (EPO) has neuroprotective properties and is currently being explored for treatment of stroke and other neurological disorders. Short-term, high-dose treatment with EPO seems to improve neurological function of stroke patients but may be associated with increased thrombotic ris...

journal_title：Thrombosis and haemostasis

authors： Kirkeby A,Torup L,Bochsen L,Kjalke M,Abel K,Theilgaard-Monch K,Johansson PI,Bjørn SE,Gerwien J,Leist M

更新日期：2008-04-01 00:00:00

abstract：:The proposed 2nd International Standard for Factor VIII and von Willebrand Factor activities in plasma, NIBSC code 87/718, was assayed against the 1st IRP, 80/511, and against fresh normal plasma, in 21 laboratories. There were no significant differences between the various assay methods for factor VIII antigen, von W...

journal_title：Thrombosis and haemostasis

authors： Heath AB,Barrowcliffe TW

更新日期：1992-08-03 00:00:00

abstract：:Alpha-enolase is an ubiquitous cytoplasmic glycolytic enzyme which also exhibits cell surface mediated functions and a structural role in the lens of some species. An alpha-enolase related molecule (alpha-ERM) is present on the surfaces of neutrophils, monocytes and monocytoid cells and has the capacity to specificall...

journal_title：Thrombosis and haemostasis

authors： Arza B,Félez J,Lopez-Alemany R,Miles LA,Muñoz-Cánoves P

更新日期：1997-09-01 00:00:00

abstract：:Platelet activation plays a pivotal role in physiological hemostasis and pathological thrombosis causing heart attack and stroke. Previous studies conclude that simultaneous activation of Gi and G12/13 signaling pathways is sufficient to cause platelet aggregation. However, using Gq knockout mice and Gq-specific inhib...

journal_title：Thrombosis and haemostasis

authors： Zhang J,Zhang Y,Zheng S,Liu Y,Chang L,Pan G,Hu L,Zhang S,Liu J,Kim S,Dong J,Ding Z

更新日期：2020-11-01 00:00:00

abstract：:The in vitro vitamin K-dependent carboxylation of peptide- or protein-bound glutamate residues is generally studied in detergent-solubilized microsomes from rat or cow liver. Under the conditions usually employed, the efficiency of the carboxylation reaction is low (less than 1% of the carboxylatable residues is conve...

journal_title：Thrombosis and haemostasis

authors： Soute BA,Ulrich MM,Vermeer C

更新日期：1987-02-03 00:00:00

abstract：:Multifunctional proteins, e.g. high molecular weight kininogen (HK, 120 kDa) and the homotrimer, thrombospondin (TSP, 540 kDa), which have more than one domain on a single polypeptide chain, are particularly well-suited to be structural elements of extracellular matrices because of their ability to bind to several mac...

journal_title：Thrombosis and haemostasis

authors： DeLa Cadena RA,Wyshock EG,Kunapuli SP,Schultze RL,Miller M,Walz DA,Colman RW

更新日期：1994-07-01 00:00:00

abstract：:Antiphospholipid antibodies (aPL) have been associated with thrombosis and pregnancy losses in patients diagnosed with antiphospholipid syndrome (APS) and enhance thrombus formation in vivo in mice, but the mechanism of thrombosis by aPL is not completely understood. It has been proposed that aPL may affect endothelia...

journal_title：Thrombosis and haemostasis

authors： Pierangeli SS,Liu X,Espinola R,Olee T,Zhu M,Harris NE,Chen PP

更新日期：2000-09-01 00:00:00

abstract：:Previous studies have demonstrated that cell-permeable cytoplasmic tail (CT) alpha(II)beta peptides can modulate the activation of alpha(IIb)b(3). As alpha(V) CT contains an alpha(II)beta homologous region, a series of cell-permeable alpha(V) and alpha(IIb) peptides were generated to determine if alpha(V) CT can modul...

journal_title：Thrombosis and haemostasis

authors： Haas TA

更新日期：2008-01-01 00:00:00

abstract：:We investigated the extent to which fibroblasts isolated from diverse tissues differ in their capacity to modulate inflammation by comparing the global gene expression profiles of cultured human fibroblasts from skin, acute and chronically inflamed synovium, lymph node and tonsil. The responses of these fibroblasts to...

journal_title：Thrombosis and haemostasis

authors： Parsonage G,Falciani F,Burman A,Filer A,Ross E,Bofill M,Martin S,Salmon M,Buckley CD

更新日期：2003-10-01 00:00:00

abstract：:Elucidation of the molecular defects responsible for antithrombin III deficiency is proceeding rapidly. In order that a record is kept of the new and duplicated mutations that are found, we have compiled a database that we plan to update annually. In this, the first report of the database, we list 6 antithrombin III l...

journal_title：Thrombosis and haemostasis

authors： Lane DA,Ireland H,Olds RJ,Thein SL,Perry DJ,Aiach M

更新日期：1991-12-02 00:00:00

abstract：:A pulmonary embolism model in hamsters was used for the quantitative evaluation of the thrombolytic and pharmacokinetic properties of variants of tissue-type plasminogen activator (t-PA). A 25 microliters 125I-fibrin labeled human plasma clot was made in vitro and injected into the jugular vein of heparinized hamsters...

journal_title：Thrombosis and haemostasis

authors： Collen D,Lijnen HR,Vanlinthout I,Kieckens L,Nelles L,Stassen JM

更新日期：1991-02-12 00:00:00

abstract：:Previous studies on recombinant human soluble thrombomodulin (rsTM) from Chinese hamster ovary cells revealed that rsTM was expressed as two proteins that differed functionally in vitro due to the presence (rsTM beta) or absence (rsTM alpha) of chondroitin-4-sulfate. The current study evaluates the in vivo behavior of...

journal_title：Thrombosis and haemostasis

authors： Nawa K,Itani T,Ono M,Sakano K,Marumoto Y,Iwamoto M

更新日期：1992-03-02 00:00:00