Abstract:
:An overview of drug metabolism, with particular focus on the cytochrome p450 system, is provided in this review. To date, there has been a growing body of literature concerning the cytochrome p450 enzyme, drug-drug interactions and the role of psychotropic medications when co-administered with medications prescribed in the medically ill population. The article provides an ability to cross-reference commonly prescribed medications to their known involvement as substrates, inhibitors or inducers of p450 enzymes. This information will permit the clinician working in an oncologic setting to better predict potential interactions based on available in vitro and in vivo data and choose psychotropics analytically when confronted with a situation of polypharmacy. A knowledge of drug interactions will decrease the uncertainty in prescription of multidrug therapies and minimize the likelihood of diminished drug efficacy or toxic reactions.
journal_name
Psychooncologyjournal_title
Psycho-oncologyauthors
Kalash GRdoi
10.1002/(SICI)1099-1611(199807/08)7:4<307::AID-PONsubject
Has Abstractpub_date
1998-07-01 00:00:00pages
307-20issue
4eissn
1057-9249issn
1099-1611journal_volume
7pub_type
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