Psychotropic drug metabolism in the cancer patient: clinical aspects of management of potential drug interactions.

Abstract:

:An overview of drug metabolism, with particular focus on the cytochrome p450 system, is provided in this review. To date, there has been a growing body of literature concerning the cytochrome p450 enzyme, drug-drug interactions and the role of psychotropic medications when co-administered with medications prescribed in the medically ill population. The article provides an ability to cross-reference commonly prescribed medications to their known involvement as substrates, inhibitors or inducers of p450 enzymes. This information will permit the clinician working in an oncologic setting to better predict potential interactions based on available in vitro and in vivo data and choose psychotropics analytically when confronted with a situation of polypharmacy. A knowledge of drug interactions will decrease the uncertainty in prescription of multidrug therapies and minimize the likelihood of diminished drug efficacy or toxic reactions.

journal_name

Psychooncology

journal_title

Psycho-oncology

authors

Kalash GR

doi

10.1002/(SICI)1099-1611(199807/08)7:4<307::AID-PON

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

307-20

issue

4

eissn

1057-9249

issn

1099-1611

journal_volume

7

pub_type

杂志文章,评审
  • A qualitative study of women's experiences of familial ovarian cancer screening.

    abstract:OBJECTIVE:One risk management strategy that women at increased familial risk of ovarian cancer may use is screening. Until recently, this has been available as part of the UK Familial Ovarian Cancer Screening Study (UKFOCSS), using ultrasound scans of the ovaries and tumour marker blood tests. The present study aimed t...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3324

    authors: Lifford KJ,Clements A,Fraser L,Lancastle D,Brain K,PsyFOCS Management Group.

    更新日期:2013-11-01 00:00:00

  • Cancer-related symptoms predict psychological wellbeing among prostate cancer survivors: results from the PiCTure study.

    abstract:BACKGROUND:Prostate cancer treatments are associated with a range of symptoms and physical side-effects. Cancer can also adversely impact on psychological wellbeing. Because many prostate cancer-related symptoms and side-effects are potentially modifiable, we investigated associations between symptoms and psychological...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3909

    authors: Sharp L,O'Leary E,Kinnear H,Gavin A,Drummond FJ

    更新日期:2016-03-01 00:00:00

  • Illness perceptions in Greek patients with cancer: a validation of the Revised-Illness Perception Questionnaire.

    abstract:OBJECTIVE:The Revised-Illness Perception Questionnaire (IPQ-R) assesses illness perceptions according to Leventhal's self-regulatory model. The aim of this paper is to present findings on the reliability and validity of the IPQ-R in a population of Greek cancer patients. METHODS:A total of 206 patients completed a Gre...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1538

    authors: Giannousi Z,Manaras I,Georgoulias V,Samonis G

    更新日期:2010-01-01 00:00:00

  • Does felt age reflect health-related quality of life in cancer patients?

    abstract::Subjective age is related to health and to life satisfaction. The present study on post-surgical cancer patients addressed two questions: (1) Do people differ in their health-related quality of life (HRQOL) depending on their felt age? (2) Is change in felt age associated with change in HRQOL? Data were collected at o...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1011

    authors: Boehmer S

    更新日期:2006-08-01 00:00:00

  • High prevalence of moral distress reported by oncologists and oncology nurses in end-of-life decision making.

    abstract:OBJECTIVE:Decisions to limit life-prolonging treatment (DLT) are often accompanied by psychological and ethical difficulties. The aim of the study is to investigate prevalence and intensity of moral distress (MD) as well as potential causes experienced by oncology physicians and nurses in DLT situations. METHODS:This ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4868

    authors: Mehlis K,Bierwirth E,Laryionava K,Mumm FHA,Hiddemann W,Heußner P,Winkler EC

    更新日期:2018-12-01 00:00:00

  • Intervening to improve psychological outcomes for men with prostate cancer.

    abstract:BACKGROUND:Prostate cancer is the most common cancer in men in the Western world with well-described negative effects from treatments. However, outcomes are highly heterogeneous. A Phase 3 trial of a psycho-educational intervention was undertaken, aiming to reduce cancer-specific and decision-related distress and impro...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/pon.3095

    authors: Chambers SK,Ferguson M,Gardiner RA,Aitken J,Occhipinti S

    更新日期:2013-05-01 00:00:00

  • Awareness of cancer, satisfaction with care, emotional distress, and adjustment to illness: an Italian multicenter study.

    abstract:OBJECTIVE:The aim of the study was to examine awareness of cancer and the relationship with distress and satisfaction with care among Italian cancer patients. METHODS:Two hundred sixty-two cancer patients consecutively admitted to the Day Hospital of four cancer centers in Italy completed the European Organisation for...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/pon.3768

    authors: Costantini A,Grassi L,Picardi A,Brunetti S,Caruso R,Nanni MG,Bonetti L,de Feudis R,Barni S,Marchetti P

    更新日期:2015-09-01 00:00:00

  • Quality of life of family caregivers 8 years after a relative's cancer diagnosis: follow-up of the National Quality of Life Survey for Caregivers.

    abstract:BACKGROUND:The long-term impact of cancer caregiving on the family caregivers' quality of life (QOL) is currently not known. This study aimed (a) to characterize family caregivers of cancer survivors at 8 years post-diagnosis in terms of multidimensional aspects of QOL and (b) to identify demographic and early caregivi...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3843

    authors: Kim Y,Shaffer KM,Carver CS,Cannady RS

    更新日期:2016-03-01 00:00:00

  • Cognition in breast cancer survivors: hormones versus depression.

    abstract:BACKGROUND: OBJECTIVE:Breast cancer survivors receiving hormone treatment and/or endorsing histories of receiving chemotherapy report changes in their cognitive capacity, which is often not supported by formal testing. To address these conflicting reports, this study examined survivors' applied cognitive capacity and ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3602

    authors: Seliktar N,Polek C,Brooks A,Hardie T

    更新日期:2015-04-01 00:00:00

  • Surgical treatment preferences in Chinese-American women with early-stage breast cancer.

    abstract::Breast-conserving treatment (BCT) is considered preferable to radical or modified radical mastectomy (MRM) for most women diagnosed with early-stage breast cancer. Studies have found that Chinese-American women are more likely to be treated with MRM, regardless of age or stage of disease. The central question posed in...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1032

    authors: Killoran M,Moyer A

    更新日期:2006-11-01 00:00:00

  • The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer.

    abstract:BACKGROUND:The ability to identify men at genetically high-risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa-specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3814

    authors: Bancroft EK,Castro E,Bancroft GA,Ardern-Jones A,Moynihan C,Page E,Taylor N,Eeles RA,Rowley E,Cox K

    更新日期:2015-11-01 00:00:00

  • Couples coping with cancer together: Successful implementation of a caregiver program as standard of care.

    abstract:OBJECTIVE:The couples coping with cancer together program (CCCT) is used to illustrate practical strategies to implement, evaluate, and grow a successful couples-based program in an NCI-designated CCC. CCCT is multimodal program utilizing psychoeducational, strategic, strengths-based, and problem-solving theoretical fr...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.5364

    authors: Bitz C,Kent EE,Clark K,Loscalzo M

    更新日期:2020-05-01 00:00:00

  • Hostility in cancer patients as an underexplored facet of distress.

    abstract:OBJECTIVE:In the present study, we aimed to assess hostility and to examine its association with formal psychiatric diagnosis, coping, cancer worries, and quality of life in cancer patients. METHODS:The World Health Organization (WHO) Composite International Diagnostic Interview (CIDI) to make an ICD-10 (International...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.5594

    authors: Grassi L,Belvederi Murri M,Riba M,de Padova S,Bertelli T,Sabato S,Nanni MG,Caruso R,Ounalli H,Zerbinati L

    更新日期:2020-11-18 00:00:00

  • Depression in patients with colorectal cancer in Saudi Arabia.

    abstract:OBJECTIVE:Persons with colon cancer experience considerable psychological stress due to physical and social changes brought on by illness, increasing their risk of depressive disorder (DD). We examine the prevalence of DD and depressive symptoms and determine baseline demographic, social, psychological, and physical he...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3706

    authors: Shaheen Al Ahwal M,Al Zaben F,Khalifa DA,Sehlo MG,Ahmad RG,Koenig HG

    更新日期:2015-09-01 00:00:00

  • Psychological impact of diagnosis and risk reduction among cancer survivors.

    abstract::Life-threatening health events prompt psychological distress that may motivate individuals to reduce health risks. If so, interventions timed to take advantage of these 'teachable moments' could be particularly effective. To explore this association, early stage prostate and breast cancer patients were identified from...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/1099-1611(200009/10)9:5<418::aid-pon474>3.

    authors: McBride CM,Clipp E,Peterson BL,Lipkus IM,Demark-Wahnefried W

    更新日期:2000-09-01 00:00:00

  • A systematic review of factors related to children's quality of life and mental health after brain tumor.

    abstract:PURPOSE:Brain tumor has been found to have a major impact on children's quality of life (QOL); yet, the subjective impact of the illness is still not well understood. This review aimed to investigate factors related to children's subjective well-being (SWB), or self-reported QOL and mental health after brain tumor. A f...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4850

    authors: Bell H,Ownsworth T,Lloyd O,Sheeran N,Chambers S

    更新日期:2018-10-01 00:00:00

  • Factors associated with adherence to physical activity guidelines in patients with prostate cancer.

    abstract:OBJECTIVE:This study aimed to estimate the proportion of patients with prostate cancer (PCa) meeting the National Physical Activity Guidelines of Australia (NPAGA) and determine sociodemographic and medical factors associated with meeting these guidelines. Secondary aims included examining physical activity (PA) levels...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3310

    authors: Chipperfield K,Fletcher J,Millar J,Brooker J,Smith R,Frydenberg M,Oh T,Burney S

    更新日期:2013-11-01 00:00:00

  • Public policy, human consequences: the gap between biomedicine and psychosocial reality.

    abstract::Despite evidence-based research demonstrating the high prevalence rates of emotional distress, medical systems continue to focus their attention on biomedical aspects of treatment leaving a significant gap in patient care. This paper reflects on values and policy and suggests that we are unlikely to change health care...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.938

    authors: McMurtry R,Bultz BD

    更新日期:2005-09-01 00:00:00

  • Determinants of physical activity among women treated for breast cancer in a 5-year longitudinal follow-up investigation.

    abstract:OBJECTIVE:To estimate the 5-year trajectory of physical activity among women with breast cancer, and to evaluate biopsychosocial variables (health status, physical symptoms, health-related quality of life (HRQL), depressive symptoms, and social support), measured soon after breast cancer diagnosis, as predictors of the...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/pon.1519

    authors: Emery CF,Yang HC,Frierson GM,Peterson LJ,Suh S

    更新日期:2009-04-01 00:00:00

  • A systematic review of men's experiences of their partner's mastectomy: coping with altered bodies.

    abstract:OBJECTIVE:To explore men's experiences of their partner's altered physique and body image as a result of mastectomy and subsequent reconstructive surgeries. DESIGN:A systematic review of qualitative and mixed-methods studies. DATA SOURCES:Ovid, EBSCOhost, Web of Science, SCOPUS and ASSIA ProQuest databases were searc...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,评审

    doi:10.1002/pon.3556

    authors: Rowland E,Metcalfe A

    更新日期:2014-09-01 00:00:00

  • Effect of the partner's health and support on cancer patients' use of general practitioner care.

    abstract:OBJECTIVE:Cancer and its treatment often have a profound impact on patients, leading to increased health care use in the years after diagnosis. Social support is an important determinant of health care use. Partners of cancer patients may not always be able to provide all support patients need and patients may then rev...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3963

    authors: Heins MJ,Hopman EP,Korevaar JC,Schellevis FG,Donker GA,Rijken PM

    更新日期:2016-05-01 00:00:00

  • Cognitive influences as mediators of family and peer support for pediatric cancer survivors' physical activity.

    abstract:OBJECTIVE:The objective of this study was to determine the extent to which self-efficacy mediates the relations between social support and childhood cancer survivors' physical activity (PA). METHODS:A structured telephone survey was conducted with 105 childhood cancer survivors aged 8-16 years. Participants completed ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3140

    authors: Gilliam MB,Madan-Swain A,Whelan K,Tucker DC,Demark-Wahnefried W,Schwebel DC

    更新日期:2013-06-01 00:00:00

  • Digital interventions to facilitate patient-provider communication in cancer care: A systematic review.

    abstract:OBJECTIVE:Patient-provider communication is a critical component of cancer care. Digital tools have been applied to facilitate cancer care and patient-provider communication. However, to date, there is no systematic review on this growing body of literature. The objective of this study is to identify the existing digit...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.5310

    authors: Hong YA,Hossain MM,Chou WS

    更新日期:2020-04-01 00:00:00

  • A follow-up study on men tested for BRCA1/BRCA2 mutations: impacts and coping processes.

    abstract:OBJECTIVE:The objective of this study was to examine cognitive, emotional, and behavioral impacts of testing for germline mutations in breast/ovarian cancer-associated genes (BRCA1/BRCA2) among men who undergo genetic testing. METHODS:A cross-sectional study compared 51 mutation carriers with 30 men who tested negativ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.2106

    authors: Shiloh S,Dagan E,Friedman I,Blank N,Friedman E

    更新日期:2013-02-01 00:00:00

  • Associated and predictive factors of sleep disturbance in advanced cancer patients.

    abstract::Little attention has been paid to sleep disturbance experienced by advanced cancer patients. The purpose of the present study was to investigate longitudinal change in sleep disturbance and to identify factors that associated with and predicted sleep disturbance among 209 consecutive terminally ill cancer patients. Pa...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1122

    authors: Akechi T,Okuyama T,Akizuki N,Shimizu K,Inagaki M,Fujimori M,Shima Y,Furukawa TA,Uchitomi Y

    更新日期:2007-10-01 00:00:00

  • The epidemiology of psychiatric disorders among women with breast cancer in South Korea: analysis of national registry data.

    abstract:OBJECTIVE:Population-based data on the epidemiology of psychiatric disorders in patients with breast cancer are lacking. Because the National Health Insurance (NHI) Program in South Korea is a compulsory social insurance system covering the entire Korean population, the NHI is a good source of information for epidemiol...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3369

    authors: Kang JI,Sung NY,Park SJ,Lee CG,Lee BO

    更新日期:2014-01-01 00:00:00

  • Psychosocial distress among oncology patients in the safety net.

    abstract:OBJECTIVE:Psychosocial distress among cancer patients leads to poor health outcomes and lower satisfaction. However, little is known about psychosocial distress among disadvantaged populations. We examined the prevalence, predictors, and follow-up experience of psychosocial distress among cancer patients within a diver...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.5525

    authors: Cimino T,Said K,Safier L,Harris H,Kinderman A

    更新日期:2020-11-01 00:00:00

  • Knowledge, attitudes and beliefs of Arabic-Australians concerning cancer.

    abstract:OBJECTIVES:To explore with Arabic-Australian patients and their communities, the cultural context of cancer, both sporadic and inherited, by examining their beliefs about its causes and the modes of communication about cancer with family, friends and the community. METHOD:The design is an ethnographic and qualitative ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1884

    authors: Saleh M,Barlow-Stewart K,Meiser B,Tucker K,Eisenbruch M,Kirk J

    更新日期:2012-02-01 00:00:00

  • Psychosocial oncology care resources in Europe: a study under the European Partnership for Action Against Cancer (EPAAC).

    abstract:BACKGROUND:Cancer is a complex health problem requiring multidisciplinary care. There are clinical guidelines available in order to improve the process and outcomes of cancer care within Europe. However, strategic action is still needed in many European Union (EU) Member States to develop or improve national cancer con...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4044

    authors: Travado L,Reis JC,Watson M,Borràs J

    更新日期:2017-04-01 00:00:00

  • Spirituality, emotional distress, and post-traumatic growth in breast cancer survivors and their partners: an actor-partner interdependence modeling approach.

    abstract:BACKGROUND:The association between spirituality and emotional health has been well documented in healthy individuals. A small literature has shown that spirituality plays a role in well-being for some breast cancer (BC) survivors; however, this link is virtually unexplored in partners/spouses of survivors. The current ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4192

    authors: Gesselman AN,Bigatti SM,Garcia JR,Coe K,Cella D,Champion VL

    更新日期:2017-10-01 00:00:00