Focal cortical dysplasia with glioproliferative changes causing seizures: report of 3 cases.

Abstract:

:In contrast to neoplasia, lesions of focal cerebral dysplasia are thought to be completed developmental processes of abnormal neuronal migration. We present three children with seizures resulting from brain lesions which pathologically demonstrate regions of both clearcut focal cortical dysplasia and also hypercellularity and monomorphism typical of proliferative lesions such as low grade glial tumor. These cases suggest the existence of a distinct subgroup of patients with prominent glioproliferative changes in association with focal cortical dysplasia, challenging the conventional dichotomy between dysplastic and proliferative categories of brain lesions. Recognition of patients with dual pathology may be of practical as well as theoretical importance.

journal_name

Pediatr Neurosurg

journal_title

Pediatric neurosurgery

authors

Madsen JR,Vallat AV,Poussaint TY,Scott RM,De Girolami U,Anthony DC

doi

10.1159/000028662

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

261-6

issue

5

eissn

1016-2291

issn

1423-0305

pii

pne28261

journal_volume

28

pub_type

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