Clinical significance of serum 7S collagen and type VI collagen levels for the diagnosis of hepatic fibrosis.

Abstract:

OBJECTIVE:To measure serum 7S collagen (7S-C) and type VI collagen (VI-C) levels by radioimmunoassay (RIA) in Chinese patients with various liver disorders and in CCl4-treated SD rats, and to investigate the significance of the elevated levels of serum 7S-C and VI-C. METHODS:Serum 7S-C and VI-C levels were measured in 40 healthy control subjects, 168 patients with various liver disorders and non-hepatic diseases, and 52 CCl4-treated SD rats by using RIA which was developed in our hospital. RESULTS:Serum 7S-C and VI-C were significantly elevated in patients with chronic active hepatitis (CAH), liver cirrhosis (LC), hepatic cellular carcinoma (HCC) (P < 0.01 respectively), chronic persistent hepatitis (CPH), and some with non-hepatic diseases (P < 0.05). Serum 7S-C, serum laminin and hyaluronic acid were well correlated. Serum 7S-C and VI-C were not closely correlated. Both collagens were correlated with serum albumin/globulin ratio, aminotransferase and total bilirubin, not with alkaline phosphatase. In CCl4-treated SD rats, serum 7S collagen and type VI collagen levels were correlated with the degree of hepatic fibrosis. CONCLUSIONS:Serum 7S collagen and type VI collagen are useful markers for diagnosing liver fibrosis. And the combined measurement of IV-C, VI-C and other markers of connective tissue metabolism or biochemical data seems to provide additional information to predict progressive hepatic fibrosis.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

Ji X,Li S,Kong X,Xu G,Chen J,Dai X

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

198-201

issue

3

eissn

0366-6999

issn

2542-5641

journal_volume

110

pub_type

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