Clinical study on the thrombolytic effect with different doses of urokinase in acute myocardial infarction. The Collaborative Research Group on Thrombolysis.

Abstract:

OBJECTIVE:To investigate the effects of different doses of intravenous domestic urokinase. METHODS:One thousand and twenty three cases of acute myocardial infarction within 6 hours after acute onset were divided randomly into two groups with 539 cases in the low dose group (urokinase 22,000IU/kg, total dose not lower than 1.2 million) and 484 in the high dose group (30,000IU/kg, total dose not more than 2.4 million). The patency of infarct-related coronary artery was assessed by uniform clinical criteria. RESULTS:In the low and high dose groups the patency rates were 67.3% and 67.8% respectively (P > 0.05); 4-week mortalities were 9.5% and 8.7% respectively (P > 0.05). Frequency of severe complications had no statistically significant difference between the two groups. Adverse bleeding was a little more frequent in the high than in the low dose group, and fatal cerebral hemorrhage in 2 cases occurred in the high dose group. CONCLUSION:Low dose urokinase, 22,000 IU per kg body weight with a total dose not lower than 1.2 million IU, is not only equally effective as high dose but also safer.

journal_name

Chin Med J (Engl)

journal_title

Chinese medical journal

authors

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

43-6

issue

1

eissn

0366-6999

issn

2542-5641

journal_volume

110

pub_type

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