Bootstrap confidence intervals for cost-effectiveness ratios: some simulation results.

Abstract:

:Recently, a number of papers have brought up the issue of how to make cost-effectiveness (CE) studies stochastic, i.e. how to obtain confidence intervals for CE ratios. In this note we present a bootstrap procedure for estimating bias-corrected confidence intervals for CE ratios. The bootstrap procedure is tested in a simulation study based on the assumptions made in a recent paper by Wakker and Klaassen in this journal. We test two variants of CE ratio bootstrap confidence intervals. The first is a bootstrap analogue of the parametric method proposed by Wakker and Klaassen which gives results similar to those obtained with the parametric method. However, computing bootstrap confidence intervals directly for the CE ratio produce results closer to the predetermined significance level.

journal_name

Health Econ

journal_title

Health economics

authors

Tambour M,Zethraeus N

doi

10.1002/(sici)1099-1050(199803)7:2<143::aid-hec322

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

143-7

issue

2

eissn

1057-9230

issn

1099-1050

pii

10.1002/(SICI)1099-1050(199803)7:2<143::AID-HEC322

journal_volume

7

pub_type

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