Gastrointestinal alcohol dehydrogenase.

Abstract:

:Alcohol dehydrogenase (ADH) consists of a family of isozymes that convert alcohols to their corresponding aldehydes using NAD+ as a cofactor. The metabolism of ethanol by gastrointestinal ADH isozymes results in the production of acetaldehyde, a highly toxic compound that binds to cellular protein and DNA if not further metabolized to acetate by acetaldehyde dehydrogenase isozymes. Acetaldehyde seems to be involved in ethanol-associated cocarcinogenesis. The metabolism of retinol and the generation of retinoic acid is a function of class I and class IV ADH, and its inhibition by alcohol may lead to an alteration of epithelial cell differentiation and cell growth and may also be involved in ethanol-associated gastrointestinal cocarcinogenesis.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Seitz HK,Oneta CM

doi

10.1111/j.1753-4887.1998.tb01692.x

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

52-60

issue

2 Pt 1

eissn

0029-6643

issn

1753-4887

journal_volume

56

pub_type

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