Abstract:
:Validity of naked eye single tube red cell osmotic fragility test ('Nestroft') was evaluated on 253 individuals divided into two groups. The HbA2 values estimated in each child was taken as gold standard. Group I comprised of 93 individuals belonging to families in which at least one of the children was suffering from beta-thalassemia major and group II consisted of 160 normal children. The sensitivity of 'Nestroft' was 95.59 per cent (grp I) & 85.71 per cent (grp II), specificity was 84.2 per cent (grp I) and 81.7 per cent (grp II) with a negative predictive value as high as 99.21 per cent in general population. The results of the test were assessed by two independent observers and P values of 0.75 and 0.69 were found in grp I and grp II, respectively. The values clearly showed that the interobserver variation was statistically insignificant thus proving it to be an objective test. Comparative analysis of 'nestroft' with red cell indices, i.e. MCV (< 70 fi) and RBC count (> 4.5 x 10(12)/l) revealed it to be the most sensitive and specific test. 'Nestroft' has emerged as the single most effective, inexpensive and easily reproducible test of population screening for beta-thalassemia trait.
journal_name
J Trop Pediatrjournal_title
Journal of tropical pediatricsauthors
Gomber S,Sanjeev,Madan Ndoi
10.1093/tropej/43.6.363subject
Has Abstractpub_date
1997-12-01 00:00:00pages
363-6issue
6eissn
0142-6338issn
1465-3664journal_volume
43pub_type
临床试验,杂志文章abstract::Till date, there is paucity of published literature on clinical manifestations of Coronavirus disease 2019 (COVID-19) in children from low-middle-income countries (LMIC). Most of the reports are from Europe, USA or China. Our study aimed to capture data on varied and unusual clinical presentation and management of MIS...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmaa127
更新日期:2021-01-29 00:00:00
abstract::This facility-based cross-sectional study was conducted to determine the patterns of disclosure of HIV positive serostatus among 145 Indian children aged >5 years. Only 60 (41.4%) children were aware of their HIV-positive status. Disclosure was most frequently done by parents [51/60 (85%)] at a mean age of 9.1 ± 1.4 y...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmq115
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To determine whether angiopoietin-1 and endostatin levels in the cord blood could predict the subsequent development of bronchopulmonary dysplasia (BPD) in preterm infants. PATIENTS AND METHODS:A total of 102 preterm (gestational age ≤ 32 weeks) infants (28 infants developed BPD and 74 had no BPD) were enrol...
journal_title:Journal of tropical pediatrics
pub_type: 临床试验,杂志文章
doi:10.1093/tropej/fmq112
更新日期:2011-10-01 00:00:00
abstract::We studied 80 children with parapneumonic effusion (PPE) with respect to the clinical manifestations and treatment alternatives as well as prospective follow-up for 1 year. Out of the 80 patients, 59 per cent were male. The mean age of the patients was 4.0 +/- 3.1 years. Mild effusion was successfully treated by antib...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmi067
更新日期:2006-02-01 00:00:00
abstract::Fifty-three children with tuberculous meningitis (TBM) were studied in parallel with 37 children with primary pulmonary complex (PPC), 32 tuberculin skin positive controls, and 38 skin negative controls for immunological evaluation. Proportions of peripheral blood total T and T helper lymphocytes (TH) were significant...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/38.1.31
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:In Tanzania, nurses play an important role in the management of patients with malaria. The study was conducted to identify the current status of the performance of nurses in the management of malaria patients, in order to provide the baseline data before the training intervention. METHODS:The study was cond...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmq100
更新日期:2011-10-01 00:00:00
abstract::Exclusive breastfeeding (EBF) is being promoted by WHO/UNICEF as the recommended mode of feeding for all infants from birth to around 6 months of age. It is also recommended for the initial few months, for infants born to HIV-positive mothers in the developing world where conditions may not be ideal for replacement fe...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/50.6.348
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:In developing countries, 80% of the births take place in the community. METHODS:Birthweight, mid-arm and chest circumferences were measured in 294 newborns admitted in a tertiary-level hospital in Kolkata between April and August 2010. Colour-coded measuring tapes were devised using receiver operating chara...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmr004
更新日期:2011-12-01 00:00:00
abstract::The composition (total solids, total protein, casein, coagulable proteins, lactose, fat, and ash) and mineral content (calcium, phosphorus, sodium, potassium, magnesium, zinc, and copper) of human milk was estimated longitudinally for the first year of lactation. Concentration of various nutrients, except zinc and cop...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/35.3.126
更新日期:1989-06-01 00:00:00
abstract:Objective:This study described the prevalence of IgG class antibodies against Toxocara spp. and their association with urticaria in 2- to 12-year-old children. Methods:This population-based cross-sectional study was conducted between May 2012 and September 2014. The study sample comprised 168 children. Blood samples w...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmw094
更新日期:2017-10-01 00:00:00
abstract::As fewer children in Thailand are exposed to hepatitis A virus (HAV) and so do not have seroprotective anti-HAV antibodies, they are becoming an important source of HAV transmission. A flexible HAV vaccination schedule would facilitate incorporation of the vaccine into existing immunization programmes, and we compared...
journal_title:Journal of tropical pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/tropej/49.6.333
更新日期:2003-12-01 00:00:00
abstract::Focus group discussions involving rural and urban residents drawn from Kanuri and Bura settlements, were conducted as part of an on-going survey of the perception and treatment of diarrhoea among major ethnic groups in northeastern Nigeria. Awareness of oral rehydration therapy (ORT) was universal among participants, ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/42.3.180
更新日期:1996-06-01 00:00:00
abstract::One thousand children with cerebral palsy (CP) were reviewed to study their clinical profile, etiological factors and associated problems. Spastic quadriplegia constituted the predominant group (61 per cent), followed by spastic diplegia (22 per cent). Dyskinetic CP was present in 7.8 per cent of the cases. Acquired C...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/48.3.162
更新日期:2002-06-01 00:00:00
abstract::In a previous study of rachitic children in Jos, Nigeria we concluded that inadequate dietary intake of calcium was the primary contributing factor to the development of their rickets. The objective of the present study was to determine the effect of calcium supplementation in 10 children with radiographically and bio...
journal_title:Journal of tropical pediatrics
pub_type: 临床试验,杂志文章
doi:10.1093/tropej/45.4.202
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Results in neonatal screening programs aiming at detection of congenital adrenal hyperplasia (CAH) can only report elevated levels of 17-hydroxy-progesterone (17-OHP), without being able to differentiate presence or absence of salt loss. AIM:To predict presence or absence of salt loss in newborn infants wit...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmv078
更新日期:2016-04-01 00:00:00
abstract::Infantile encephalitic beriberi (IEBB) is a rare form of thiamine deficiency and is poorly described. A proportion of Leigh's disease (LD) patients have similar clinical picture and response to thiamine as beriberi, leading to confusion in diagnosis and management. Data on IEBB and LD is scarce and status of thiamine ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmn031
更新日期:2008-10-01 00:00:00
abstract::We report diagnosis, treatment and evolution of cases of ocular toxocariasis in specialized consultation in Quindío, Colombia. No cases were seen during the 2000-17 period, but five cases were confirmed from November 2017 to March 2019; two children resulted with definitive loss of vision on the affected eye. Studies ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmaa096
更新日期:2020-12-13 00:00:00
abstract:INTRODUCTION:Early diagnosis and treatment is necessary to prevent HIV-infected infants progressing to AIDS. Antibody testing is not confirmatory before the age of 18 months and PCR not widely available in resource-poor settings. We studied the accuracy of CD4(+) T-lymphocyte count, CD4% and CD4/CD8 ratio as surrogate ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmr102
更新日期:2012-10-01 00:00:00
abstract::Congenital abnormalities are important causes of morbidity and mortality in children and significantly add to the burdens on healthcare in developing countries. Unfortunately, there remains a paucity of information on congenital birth defects in most developing countries. This is a 4-year prospective study that assess...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmx067
更新日期:2018-08-01 00:00:00
abstract::The objectives of this study were to determine causes of admission to a district hospital neonatal nursery; to describe outcomes; and to determine risk factors for these outcomes. The study was based at the neonatal nursery of Hlabisa hospital, KwaZulu/Natal; 149 consecutive admissions to the nursery between May and N...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/45.2.76
更新日期:1999-04-01 00:00:00
abstract::We reported the case of a boy who fled from Chechnya to Belgium. He was diagnosed with a human immune deficiency virus (HIV)/Visceral leishmaniasis (VL) coinfection. In both countries, the prevalence of HIV-infected children is low and VL is not endemic. Migration of people results in confrontation with diseases that ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmr024
更新日期:2011-12-01 00:00:00
abstract::The seroepidemiology of infection due to rubella virus in Saudi Arabia was investigated in various age groups including unvaccinated children (newborn to 15 years of age) using a newer rubella antibody test system, the ELISA with maximum sensitivity and reliability. The assessment of the immune status indicated the lo...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/35.4.169
更新日期:1989-08-01 00:00:00
abstract::Interleukin-12 receptor beta1 IL12RB1 deficiency causes vulnerability to poorly virulent mycobacteria and nontyphoid Salmonella species. We describe a 2.5 year-old girl with IL12RB1 deficiency, caused by a homozygous mutation in this gene, who presented with recurrent bacteremia caused by Salmonella spp. ...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fml001
更新日期:2006-08-01 00:00:00
abstract::With the aim of studying the feeding patterns in infants under 6 months of age, 451 mothers attending the children's clinic in two university hospitals in the north of Tehran were interviewed. All babies had been born in hospital and > 98 per cent had been breastfed during the first few hours of birth. The rate of ful...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/49.2.89
更新日期:2003-04-01 00:00:00
abstract::The etiological spectrum of 558 children (< 16 years) with partial seizures seen in a university hospital in south India, was analysed using syndromic classification proposed by the International League Against Epilepsy (ILAE). Partial seizures accounted for 57 per cent of childhood epilepsies. Idiopathic localization...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/46.4.202
更新日期:2000-08-01 00:00:00
abstract::To identify the immunization providers' characteristics associated with immunization rate in children younger than 2 years. A cohort and a cluster sampling design were implemented; 528 children between 18 and 70 months of age were sampled in five public health clinics in Mosul-Iraq. Providers' characterizations were o...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fms014
更新日期:2012-12-01 00:00:00
abstract::Although group A meningococcal disease is a major cause of child morbidity and mortality in sub-Saharan Africa, little is known about vitamin A status and T-cell subpopulations in affected children. A prospective study of vitamin A levels and T-cell subpopulations was conducted in 41 children hospitalized for meningoc...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/42.5.287
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:HIV-infected adolescents are a heterogeneous population; source of infection, immunodeficiency severity and antiretroviral (ARV) experience vary. Here, we describe youth followed in an observational study at Latin American sites of the NICHD International Site Development Initiative (NISDI). METHODS:The NISD...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/fmq068
更新日期:2011-06-01 00:00:00
abstract::This study was carried out to determine the vitamin A status and nutritional intake of carotenoids of 213 children between the ages of 6 months and 6 years in a rural community in Nigeria. There were 109 males and 104 females. A total of 57 (26.8 per cent) children were deficient in serum retinol levels (< 10 microg/d...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/49.1.42
更新日期:2003-02-01 00:00:00
abstract::Haemolysin production (Hly) and mannose-resistant haemagglutination induction (MRHA) of human (H), bovine (B), and both (HB) erythrocytes was investigated in strains of E. coli isolated from 142 cases of children with diarrhoea aged 0-36 months. Haemolysin production was more frequent in strains isolated from children...
journal_title:Journal of tropical pediatrics
pub_type: 杂志文章
doi:10.1093/tropej/39.3.183
更新日期:1993-06-01 00:00:00