Abstract:
:Autonomic activity and respiration were studied in Rett syndrome (RS) and age matched controls. Breathing movements were monitored using a pletysmograph around the chest. Sympathetic activity was monitored by measuring blood pressure (BP) using the Finapres. Cardiac parasympathetic activity was monitored by measuring the cardiac response to baroreflex using the NeuroScope which outputs measure of cardiac vagal tone (CVT) in units of a linear vagal scale (LVS). Resting CVT (means +/- SEM) was 10.5 +/- 0.9 units in the LVS and BP was 94.6 +/- 6.4 mmHg in controls. The BP was 78 +/- 4.33 mmHg and CVT was 3.6 +/- 0.7 units in the LVS in girls with RS, 65% lower than in their age matched controls (p < 0.001), but equal to previously reported level in neonates. Each girl with RS had at least 6 types of breathing dysrhythmias, a sign of instability of the respiratory oscillator. The sympathetic system controlled the HR and BP smoothly during breath holding in control girls, but there were oscillations and rebounds in RS. The HR and BP were under parasympathetic influence during hyperventilation in normal girls but not in RS. The CVT was invariably withdrawn at the height of sympathetic activity during both hyperventilation and breath holding in RS, leading to sympathovagal imbalance with the risk of cardiac arrhythmias and possibly sudden death. Neonatal level of CVT, poor autonomic integration and multiple breathing dysrhythmias shows medullary immaturity in RS. It is the first demonstration of immaturity of the brain which could be used for screening in early childhood and potentially useful for diagnosis and management of RS.
journal_name
Eur Child Adolesc Psychiatryjournal_title
European child & adolescent psychiatryauthors
Julu PO,Kerr AM,Hansen S,Apartopoulos F,Jamal GAsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
47-54eissn
1018-8827issn
1435-165Xjournal_volume
6 Suppl 1pub_type
杂志文章abstract::Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research focuses on adult indiv...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-019-01458-7
更新日期:2020-09-01 00:00:00
abstract::This is the first clinical description of a detailed psychological, speech, and language phenotype of four young children (< 5 years) with Velo-Cardio-Facial syndrome (VCFS) due to a deletion on chromosome 22 (22q11.2). The reported elevated risk of developing schizophrenia or bipolar disorder in adolescence for indiv...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050005
更新日期:2000-06-01 00:00:00
abstract::Pediatric anxiety is associated with comorbid externalizing behaviors and social problems, and these associations may be related to altered emotion processing. The late positive potential (LPP), an event-related potential component, is a neural marker of emotion processing, and there is evidence that anxious youth exh...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-016-0883-9
更新日期:2017-02-01 00:00:00
abstract::We compared the predictability of the behaviour of hyperactive children with that of aggressive children, combined hyperactive/aggressive children and normal children. Detailed behaviour measurements relating to each child and an experimenter were recorded during playroom session. Predictability was expressed in infor...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF00571673
更新日期:1996-09-01 00:00:00
abstract::We compared four instruments commonly used to screen for and diagnose Attention-Deficit/Hyperactivity Disorder (ADHD) in children. The Bergen Child Study included a DSM-IV ADHD symptom list and the Strengths and Difficulties Questionnaire (SDQ) as screen in Phase one. Phase two included the parent Development and Well...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-013-0442-6
更新日期:2014-04-01 00:00:00
abstract::Infants' temperamental anger or frustration reactions are highly stable, but are also influenced by maturation and experience. It is yet unclear why some infants high in anger or frustration reactions develop disruptive behavior problems whereas others do not. We examined family regularity, conceptualized as the consi...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-015-0797-y
更新日期:2016-07-01 00:00:00
abstract::Previous studies have suggested environmental factors may contribute to the risk of attention-deficit/hyperactivity disorder (ADHD). The current meta-analysis examined (1) the difference in the duration of maternal breastfeeding between children with and without ADHD, and (2) the association between maternal breastfee...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,meta分析
doi:10.1007/s00787-018-1182-4
更新日期:2019-01-01 00:00:00
abstract::This study investigates the prevalence and subtypes of conduct disorder (CD) and behavioral problems among youth in two communities characterized by prolonged parent-child separation upon immigration. CD and problem behaviors were assessed in 252 Caribbean-Canadian and Filipino-Canadian adolescents (12-19-year-old) us...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-007-0640-1
更新日期:2008-08-01 00:00:00
abstract::To examine child factors and parental characteristics as predictors of discrepancies between parents' ratings of externalizing and internalizing behavior problems in a sample of preschool children with ADHD and behavior problems and in a nonclinical sample. We investigated correspondence and discrepancies between pare...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-016-0897-3
更新日期:2017-03-01 00:00:00
abstract::Despite the fact that juvenile fire involvement is associated with significant injuries and is highly correlated with diverse maladjustment characteristics, firesetting has never been empirically evaluated in Italy. Participants included 567 youth between 11 and 18 years of age. This investigation attempted to address...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-007-0664-6
更新日期:2008-06-01 00:00:00
abstract::Formal thought disorder (FTD) is a disruption in the flow of thought, which is inferred from disorganisation of spoken language. FTD in autism spectrum disorders (ASD) might be a precursor of psychotic disorders or a manifestation of ASD symptom severity. The current longitudinal study is a seven-year follow-up of 91 ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0552-9
更新日期:2015-02-01 00:00:00
abstract::Current pharmacological approaches have failed to provide complete remission for patients with Attention-Deficit/Hyperactivity Disorder (ADHD). This study aimed to evaluate the efficacy and tolerability of resveratrol (that have been shown to have antioxidative, anti-inflammatory, and anti-apoptotic effects) as an adj...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01562-z
更新日期:2020-05-24 00:00:00
abstract::Children with autism-spectrum disorders (ASD) often fail laboratory false-belief tests of theory of mind (ToM). Yet how this impacts on their everyday social behavior is less clear, partly owing to uncertainty over which specific everyday conversational and social skills require ToM understanding. A new caregiver-repo...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-008-0711-y
更新日期:2009-02-01 00:00:00
abstract::Despite sizeable short-term effects of neurofeedback (NF) therapy on attention-deficit and hyperactivity disorder (ADHD), longer-term clinical, comorbidity and self-regulation outcomes are less systematically studied. The aim of this largest NF follow-up to date was to evaluate these outcomes 6 months after NF compare...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00787-018-01271-8
更新日期:2019-08-01 00:00:00
abstract::The functional Val158Met COMT polymorphism appears to affect a host of behaviours mediated by the pre-frontal cortex, and has been found associated to the risk for disruptive behaviours including ADHD. Parental socioeconomic status (SES) has also been reported as a predictor for the same childhood disorders. In a gene...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-009-0080-1
更新日期:2010-07-01 00:00:00
abstract::Eating disorders have attracted steadily expanding clinical and scientific attention since second half of the 19(th) century and, particularly, after the core descriptions of anorexia nervosa had been delivered by Gull and Lasègue. In this review, we attempt to illustrate perspectives on eating disorders that have eme...
journal_title:European child & adolescent psychiatry
pub_type: 历史文章,杂志文章,评审
doi:10.1007/s00787-003-1102-z
更新日期:2003-01-01 00:00:00
abstract:: ...
journal_title:European child & adolescent psychiatry
pub_type: 社论
doi:10.1007/s00787-018-1165-5
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To compare the psychosocial profile and suicidal behavior of 110 pregnant teenagers (PT) with 110 non-pregnant teenagers (NPT). METHOD:Subjects were matched by age and residential district. The research instruments used were a structured clinical interview and a self-reporting questionnaire based on psychome...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-007-0668-2
更新日期:2008-09-01 00:00:00
abstract::The Revised Behaviour Summarized Evaluation Scale (BSE-R) was developed for the objective evaluation of autistic behaviours in order to facilitate the recording of the evolution of developmentally disabled children. Among its 29 items, 13 items that precisely describe the degree of autistic behaviours were extracted b...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF01980489
更新日期:1995-10-01 00:00:00
abstract::The Strengths and Difficulties Questionnaire (SDQ) is used to measure psychopathological symptoms in children and adolescents from 4 to 17 years old, but its underlying structure is still a matter of debate. Indeed, on the basis of a systematic review of English and non-English articles conducted using multiple databa...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-015-0679-3
更新日期:2015-10-01 00:00:00
abstract::It was examined how juvenile psychiatric disorders and adult schizotypal symptoms are associated. 731 patients of the Department of Child and Adolescent Psychiatry of the University Medical Centre Utrecht, the Netherlands, with mean age of 12.1 years (SD = 4.0) were reassessed at the mean age of 27.9 years (SD = 5.7) ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-013-0409-7
更新日期:2013-11-01 00:00:00
abstract::Information on behavior of children with Prader-Willi syndrome (PWS) and the effect of growth hormone (GH) treatment is scarce. Parents report less problem behavior during GH treatment. Forty-two pre-pubertal children, aged 3.5-14 years were studied in a randomized controlled GH trial (RCT) during 2 years, followed by...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00787-014-0662-4
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to investigate capacity, demographic composition, and patterns of practice of Dutch child and adolescent psychiatrists, and to compare these findings with the results of a similar investigation in 1996. METHOD:A postal survey was sent out to all Dutch child and adolescent psychiatris...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-005-0480-9
更新日期:2005-09-01 00:00:00
abstract::The aim was to study the association between preschool behavioural problems and emotional symptoms in 10- to 12-year-old children. The study was based on the Aarhus Birth cohort, Denmark, and included 1,336 children. Based on the parent-administered preschool behaviour questionnaire (PBQ), we identified three not mutu...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-010-0128-2
更新日期:2010-10-01 00:00:00
abstract::Consultation-liaison psychiatry emerged in the late thirties as a bridge between body and mind splitting of medical care. Setting-up of consultation-liaison services in general hospitals began some years later and is still developing in many countries. Paediatric consultation-liaison services share some general charac...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章,评审
doi:10.1007/BF00573633
更新日期:1997-03-01 00:00:00
abstract::Deficits in motor and imitation abilities are a core finding in autism spectrum disorders (ASD), but impaired motor functions are also found in attention deficit/hyperactivity disorder (ADHD). Given recent theorising about potential aetiological overlap between the two disorders, the present study aimed to assess diff...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-015-0753-x
更新日期:2015-12-01 00:00:00
abstract::While parental psychological distress is a commonly examined risk factor in the development and maintenance of child's emotional and behavioral problems, there is an incomplete understanding of the unique contribution of the father. The current study examines whether paternal psychological distress (i.e., depression, ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-020-01613-5
更新日期:2020-08-09 00:00:00
abstract::Children meeting the Child Behavior Checklist Dysregulation Profile (CBCL-DP) suffer from high levels of co-occurring internalizing and externalizing problems. Little is known about the cognitive abilities of these children with CBCL-DP. We examined the relationship between CBCL-DP and nonverbal intelligence. Parents ...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s00787-014-0551-x
更新日期:2014-11-01 00:00:00
abstract::The primary purpose of this study was to investigate autistic children's scripts for social routines. Scripts specify familiar events in terms of who does what, when, to whom, and why. Scripts are verbalizations of mental event representations, containing and organizing generalized knowledge of how the world works. Sc...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/s007870050082
更新日期:1999-03-01 00:00:00
abstract::A large number of investigation techniques are used to establish the relationships between the clinical and biological data which are necessary for physiopathological analysis in the field of developmental disorders. It therefore seemed necessary to develop a quantified grouping system, based on developmental assessme...
journal_title:European child & adolescent psychiatry
pub_type: 杂志文章
doi:10.1007/BF01977740
更新日期:1995-04-01 00:00:00