Effects of methyl mercury on the in vivo release of dopamine and its acidic metabolites DOPAC and HVA from striatum of rats.

Abstract:

:Mercury is a neurotoxic agent that produces different effects on the brain. In the present work, the effects of chronic doses of methyl mercury (MeHg) were studied on the dopaminergic system of the rat striatum, using microdialysis coupled to high-performance liquid chromatography in order to quantify the in vivo release of dopamine (DA) and its acidic metabolites DOPAC and HVA. The administration of an equivalent total dose of 6 mg/kg of MeHg induced significant increases in the striatal release of DA and/or its acidic metabolites, independently of the pattern of administration. These effects are discussed on the base of the release and the metabolization of DA. In conclusion, the effect of MeHg administered under these experimental conditions on the in vivo release of DA and its metabolites seems to have a dose-dependent component and seems to be an accumulative process.

journal_name

Ecotoxicol Environ Saf

authors

Faro LR,Durán R,do Nascimento JL,Alfonso M,Picanço-Diniz CW

doi

10.1006/eesa.1997.1567

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

95-8

issue

2

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(97)91567-0

journal_volume

38

pub_type

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