Abstract:
:Mercury is a neurotoxic agent that produces different effects on the brain. In the present work, the effects of chronic doses of methyl mercury (MeHg) were studied on the dopaminergic system of the rat striatum, using microdialysis coupled to high-performance liquid chromatography in order to quantify the in vivo release of dopamine (DA) and its acidic metabolites DOPAC and HVA. The administration of an equivalent total dose of 6 mg/kg of MeHg induced significant increases in the striatal release of DA and/or its acidic metabolites, independently of the pattern of administration. These effects are discussed on the base of the release and the metabolization of DA. In conclusion, the effect of MeHg administered under these experimental conditions on the in vivo release of DA and its metabolites seems to have a dose-dependent component and seems to be an accumulative process.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Faro LR,Durán R,do Nascimento JL,Alfonso M,Picanço-Diniz CWdoi
10.1006/eesa.1997.1567subject
Has Abstractpub_date
1997-11-01 00:00:00pages
95-8issue
2eissn
0147-6513issn
1090-2414pii
S0147-6513(97)91567-0journal_volume
38pub_type
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