The prognostic significance of Ki-67 labeling indices for oligodendrogliomas.

Abstract:

OBJECTIVE:The prognostic significance of quantitative measurement of tumor proliferative activity was evaluated for oligodendroglial tumors. METHODS:Ki-67/MIB-1 immunochemistry was used to measure proliferative activity in 81 oligodendrogliomas and oligoastrocytomas. The relationship among survival, proliferation, histological features, and clinical variables were evaluated using a Cox proportional hazards analysis. RESULTS:After stratifying by histological grade and adjusting for age at diagnosis, there was a significant association between the Ki-67/MIB-1 labeling index (LI) (percentage of positive cells) and survival (P = 0.04). This association was illustrated further by the significantly different survival of two groups based on LI ranges of less than or equal to 5 and greater than 5 (P < 0.0001). CONCLUSION:The poor correlation between mitotic figures and survival in oligodendrogliomas that has been reported previously emphasizes the need for an accurate method to measure proliferative activity. Our study demonstrated the usefulness of the Ki-67/MIB-1 LI and demonstrated that LI ranges can be defined for clinical application.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Coons SW,Johnson PC,Pearl DK

doi

10.1097/00006123-199710000-00021

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

878-84; discussion 884-5

issue

4

eissn

0148-396X

issn

1524-4040

journal_volume

41

pub_type

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