Abstract:
:A novel drug delivery system for osteomyelitis was developed in which a porous hydroxyapatite block (HAB) is loaded with antibiotic by a centrifugation method. In this study, implantation of HABs loaded with the aminoglycoside antibiotic, arbekacin, were tested in established Staphylococcus aureus osteomyelitis in the proximal tibia of rats after debridement of the marrow cavity. The animals were observed for radiographic signs of infection and tissue was examined histologically. The infections were also evaluated by bone cultures. Bacterial counts were statistically lower in rats implanted with an antibiotic-loaded HAB than in those given a drug-free HAB. Radiographical and histological observations also showed beneficial effects of the antibiotic-loaded implant. The results suggest that the centrifugation method for loading HABs provides a simple drug delivery system. These antibiotic-loaded HABs may be useful for filling grafts in osteomyelitis.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Itokazu M,Ohno T,Tanemori T,Wada E,Kato N,Watanabe Kdoi
10.1099/00222615-46-9-779subject
Has Abstractpub_date
1997-09-01 00:00:00pages
779-83issue
9eissn
0022-2615issn
1473-5644journal_volume
46pub_type
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