Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor.

Abstract:

:A mouse cDNA encoding for matrilin-3, the third member of the novel matrilin family of extracellular matrix proteins, was cloned. The protein precursor of 481 amino acids consists of a putative signal peptide, a short positively charged sequence, a single vWFA-like domain followed by four epidermal growth factor-like modules and a potential coiled-coil alpha-helical oligomerization domain at the C-terminus. It is the smallest member of the matrilin family with a predicted Mr of the mature protein of 48 902. The primary structure of a C-terminal portion of 310 amino acids of the human matrilin-3 was determined and showed a sequence identity to the mouse matrilin-3 of 84.8%. Northern blot hybridization of mouse matrilin-3 mRNA showed a 2.9 kb mRNA expressed in sternum, femur and trachea and indicates a cartilage-specific expression.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Wagener R,Kobbe B,Paulsson M

doi

10.1016/s0014-5793(97)00895-8

subject

Has Abstract

pub_date

1997-08-11 00:00:00

pages

129-34

issue

1

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(97)00895-8

journal_volume

413

pub_type

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