Abstract:
OBJECTIVE:To test the hypothesis that hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) may decrease the risk of community acquired pneumonia. DESIGN:Population based case-control study. SETTING:Group Health, a large integrated healthcare delivery system. Population Immunocompetent, community dwelling Group Health members aged 65 to 94; two matched controls for each case with pneumonia. Information on comorbid illnesses and functional and cognitive status, potential confounders of the association between statin use and risk of pneumonia, came from medical record review and computerised pharmacy data. MAIN OUTCOME MEASURE:Adjusted estimates of risk of pneumonia in relation to current statin use. RESULTS:1125 validated cases of pneumonia and 2235 matched controls were identified. Compared with controls, cases were more likely to have chronic lung and heart disease, especially severe disease, and functional or cognitive impairment. Current statin use was present in 16.1% (181/1125) of cases and 14.6% (327/2235) of controls (adjusted odds ratio 1.26, 95% confidence interval 1.01 to 1.56). Among cases admitted to hospital and matched controls, current statin use was present in 17.2% (68/395) of cases and 14.2% (112/788) of controls (adjusted odds ratio 1.61, 1.08 to 2.39, compared with non-use). In people in whom statins were indicated for secondary prevention, the adjusted odds ratio for risk of pneumonia in relation to current statin use was 1.25 (0.94 to 1.67); in those with no such indication, it was 0.81 (0.46 to 1.42). CONCLUSIONS:Statin use was not associated with decreased risk of pneumonia among immunocompetent, community dwelling older people. Findings of previous studies may reflect "healthy user" bias.
journal_name
BMJjournal_title
BMJ (Clinical research ed.)authors
Dublin S,Jackson ML,Nelson JC,Weiss NS,Larson EB,Jackson LAdoi
10.1136/bmj.b2137subject
Has Abstractpub_date
2009-06-16 00:00:00pages
b2137eissn
0959-8138issn
1756-1833journal_volume
338pub_type
杂志文章abstract:OBJECTIVES:To evaluate current processes by which young children presenting with a febrile illness but suspected of having serious bacterial infection are diagnosed and treated, and to develop and test a multivariable model to distinguish serious bacterial infections from self limiting non-bacterial illnesses. Design T...
journal_title:BMJ (Clinical research ed.)
pub_type: 杂志文章
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更新日期:2010-04-20 00:00:00
abstract:OBJECTIVE:To design and evaluate a computer advisory system for the treatment of gestational trophoblastic tumour. DESIGN:A comparison of clinicians' treatment decisions with those of the computer system. Two datasets were used: one to calibrate the system and one to independently evaluate it. SETTING:Department of m...
journal_title:BMJ (Clinical research ed.)
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journal_title:BMJ (Clinical research ed.)
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doi:10.1136/bmj.307.6917.1465
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journal_title:BMJ (Clinical research ed.)
pub_type: 杂志文章,评审
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更新日期:1997-02-08 00:00:00
abstract:OBJECTIVE:To measure the prevalence of breast feeding and to examine the value of using information collected on Guthrie cards (used for detecting inherited metabolic disease and hypothyroidism when newborn infants are 7 days old) to calculate this prevalence. DESIGN:Analysis, by geographical area and maternity unit, ...
journal_title:BMJ (Clinical research ed.)
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doi:10.1136/bmj.308.6932.824
更新日期:1994-03-26 00:00:00
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journal_title:BMJ (Clinical research ed.)
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pub_type: 杂志文章,评审
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更新日期:2017-02-22 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2016-09-13 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-03-10 00:00:00
abstract:OBJECTIVES:To investigate the possible influence of attendance at cultural events, reading books or periodicals, making music or singing in a choir as determinants for survival. DESIGN:A simple random sample was drawn of 15,198 individuals aged 16-74 years. Of these, 85% (12,982) were interviewed by trained non-medica...
journal_title:BMJ (Clinical research ed.)
pub_type: 杂志文章
doi:10.1136/bmj.313.7072.1577
更新日期:1996-12-21 00:00:00
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pub_type: 杂志文章
doi:10.1136/bmj.h2388
更新日期:2015-06-02 00:00:00
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更新日期:2019-11-27 00:00:00
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更新日期:2011-07-07 00:00:00
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pub_type: 杂志文章
doi:10.1136/bmj.38313.624352.8F
更新日期:2005-01-29 00:00:00
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doi:10.1136/bmj.f4752
更新日期:2013-08-06 00:00:00
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doi:10.1136/bmj.321.7253.88
更新日期:2000-07-08 00:00:00
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doi:10.1136/bmj.297.6663.1574
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更新日期:1989-11-25 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2007-11-03 00:00:00
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更新日期:2016-06-07 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1136/bmj.c6801
更新日期:2010-12-09 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2006-04-22 00:00:00
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更新日期:1993-10-09 00:00:00
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更新日期:1997-07-05 00:00:00
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journal_title:BMJ (Clinical research ed.)
pub_type: 杂志文章
doi:10.1136/bmj.e7895
更新日期:2012-11-27 00:00:00
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更新日期:2010-09-10 00:00:00
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更新日期:2012-12-04 00:00:00