Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs).

abstract：:In response to endovascular injury, platelet-derived growth factor-BB (PDGF-BB) and basic fibroblast growth factor (bFGF) are released locally and modulate vascular smooth muscle cells (SMC) proliferation and migration within the vascular wall. The aim of the present in vitro study was to determine how rat aorta SMC r...

journal_title：Journal of cell science

authors： Facchiano A,De Marchis F,Turchetti E,Facchiano F,Guglielmi M,Denaro A,Palumbo R,Scoccianti M,Capogrossi MC

更新日期：2000-08-01 00:00:00

abstract：:The human Ras superfamily of small GTPases controls essential cellular processes such as gene expression and cell proliferation. As their deregulation is widely associated with human cancer, small GTPases and their regulatory proteins have become increasingly attractive for the development of novel therapeutics. Class...

journal_title：Journal of cell science

authors： Koraïchi F,Gence R,Bouchenot C,Grosjean S,Lajoie-Mazenc I,Favre G,Cabantous S

更新日期：2018-01-08 00:00:00

abstract：:Rho GTPases and their downstream effectors regulate changes in the actin cytoskeleton that underlie cell motility and adhesion. They also participate, with RhoA, in the regulation of gene transcription by activating serum response factor (SRF)-mediated transcription from the serum response element (SRE). SRF-mediated ...

journal_title：Journal of cell science

authors： Xie Y,Tan EJ,Wee S,Manser E,Lim L,Koh CG

更新日期：2008-02-15 00:00:00

abstract：:The influence of extracellular environmental factors on preimplantation rat blastocysts was tested by determining the number of embryos which escaped from their zonae pellucidae, followed by attachment and outgrowth of trophoblast giant cells, after 72 h in culture Uterine luminal ocmponents from individual females, o...

journal_title：Journal of cell science

authors： Surani MA

更新日期：1977-06-01 00:00:00

abstract：:Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous system, facilitates water movement into and out of the brain. Here, we identify a novel role for aquaporin-4 in astroglial cell migration, as occurs during glial scar formation. Astroglia cultured from the neocortex of aquaporin...

journal_title：Journal of cell science

authors： Saadoun S,Papadopoulos MC,Watanabe H,Yan D,Manley GT,Verkman AS

更新日期：2005-12-15 00:00:00

abstract：:The endoplasmic reticulum-Golgi intermediate compartment (ERGIC) defined by the cycling lectin ERGIC-53 consists of tubulovesicular clusters, but it is unknown if these membranes are transport vehicles or stationary entities. Here, we show by live imaging that GFP-ERGIC-53 mainly localizes to long-lived stationary and...

journal_title：Journal of cell science

authors： Ben-Tekaya H,Miura K,Pepperkok R,Hauri HP

更新日期：2005-01-15 00:00:00

abstract：:Voltage-gated Ca2+ (CaV) channels couple membrane depolarization to Ca2+ influx, triggering a range of Ca2+-dependent cellular processes. CaV channels are, therefore, crucial in shaping neuronal activity and function, depending on their individual temporal and spatial properties. Furthermore, many neurotransmitters an...

journal_title：Journal of cell science

authors： Mustafá ER,López Soto EJ,Martínez Damonte V,Rodríguez SS,Lipscombe D,Raingo J

更新日期：2017-11-15 00:00:00

abstract：:Hematopoietic and vascular endothelial cells constitute the circulatory system and are both generated from the ventral mesoderm. However, the molecules and signaling pathways involved in ventral mesoderm formation and specification remain unclear. We found that zebrafish etv5a was expressed in the ventral mesoderm dur...

journal_title：Journal of cell science

authors： Chen SY,Shih HY,Lin SJ,Hsiao CD,Li ZC,Cheng YC

更新日期：2013-12-15 00:00:00

abstract：:Increased deposition of collagen in extracellular matrix (ECM) leads to increased tissue stiffness and occurs in breast tumors. When present, this increases tumor invasion and metastasis. Precisely how this deposition is regulated and maintained in tumors is unclear. Much has been learnt about mechanical signal transd...

journal_title：Journal of cell science

authors： Zhang K,Grither WR,Van Hove S,Biswas H,Ponik SM,Eliceiri KW,Keely PJ,Longmore GD

更新日期：2016-05-15 00:00:00

abstract：:The ryanodine receptor (RyR) is an ion channel composed of four identical subunits mediating calcium efflux from the endo/sarcoplasmic reticulum of excitable and non-excitable cells. We present several lines of evidence indicating that the RyR2 N-terminus is capable of self-association. A combination of yeast two-hybr...

journal_title：Journal of cell science

authors： Zissimopoulos S,Viero C,Seidel M,Cumbes B,White J,Cheung I,Stewart R,Jeyakumar LH,Fleischer S,Mukherjee S,Thomas NL,Williams AJ,Lai FA

更新日期：2013-11-01 00:00:00

abstract：:Errors during the first meiotic division are common in our species, but virtually all occur during female meiosis. The reason why oogenesis is more error prone than spermatogenesis remains unknown. Normal segregation of homologous chromosomes at the first meiotic division (MI) requires coordinated behavior of the sist...

journal_title：Journal of cell science

authors： Hodges CA,LeMaire-Adkins R,Hunt PA

更新日期：2001-07-01 00:00:00

abstract：:We have examined the pattern of expression of four different matrix metalloproteinases (MMPs), collagenase, stromelysin, 92 kD gelatinase, and 72 kD gelatinase, by primary and passaged cultures of rabbit corneal fibroblasts. Primary cultures of this cell type have previously been shown to reproduce the normal tissue r...

journal_title：Journal of cell science

authors： Fini ME,Girard MT

更新日期：1990-10-01 00:00:00

abstract：:The model organism Neurospora crassa undergoes programmed cell death when exposed to staurosporine. Here, we show that staurosporine causes defined changes in cytosolic free Ca(2+) ([Ca(2+)]c) dynamics and a distinct Ca(2+) signature that involves Ca(2+) influx from the external medium and internal Ca(2+) stores. We i...

journal_title：Journal of cell science

authors： Gonçalves AP,Cordeiro JM,Monteiro J,Muñoz A,Correia-de-Sá P,Read ND,Videira A

更新日期：2014-09-01 00:00:00

abstract：:Several cell types express inducible nitric oxide synthase (NOS2) in response to exogenous insults such as bacterial lipopolysaccharide (LPS) or proinflammatory cytokines. For instance, muscular cells treated with LPS and interferon gamma (IFN-gamma) respond by increasing the mRNA and protein levels of NOS2, and synth...

journal_title：Journal of cell science

authors： Navarro-Lérida I,Portolés MT,Barrientos AA,Gavilanes F,Boscá L,Rodríguez-Crespo I

更新日期：2004-04-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a transcriptional regulator of genes involved in xenobiotic metabolism. Increasingly clear is also the role of the AhR in the control of cell growth and proliferation. By analyzing differential patterns of gene expression between wild-type (AhR+/+) and null (AhR-/-) mouse embryo ...

journal_title：Journal of cell science

authors： Santiago-Josefat B,Mulero-Navarro S,Dallas SL,Fernandez-Salguero PM

更新日期：2004-02-29 00:00:00

abstract：:Neurofilaments (NFs) are the major intermediate filaments (IFs) of mature neurons. They play important roles in the structure and function of axons. Recently, two mutations in the neurofilament light (NFL) subunit have been identified in families affected by Charcot-Marie-Tooth (CMT) neuropathy type 2. We have charact...

journal_title：Journal of cell science

authors： Perez-Olle R,Leung CL,Liem RK

更新日期：2002-12-15 00:00:00

abstract：:The C terminus of the tubulin alpha-subunit of most eukaryotic cells undergoes a cycle of tyrosination and detyrosination using two specific enzymes, a tubulin tyrosine ligase (TTL) and a tubulin carboxypeptidase. Although this enzyme cycle is conserved in evolution and exhibits rapid turnover, the meaning of this mod...

journal_title：Journal of cell science

authors： Lafanechère L,Courtay-Cahen C,Kawakami T,Jacrot M,Rüdiger M,Wehland J,Job D,Margolis RL

更新日期：1998-01-01 00:00:00

abstract：:Oncogenic forms of the non-receptor tyrosine kinase Src alter cell structure, in particular the actin cytoskeleton and the adhesion networks that control cell migration, and also transmit signals that regulate proliferation and cell survival. Recent work indicates that they do so by influencing the RhoA-ROCK pathway t...

journal_title：Journal of cell science

authors： Frame MC

更新日期：2004-03-01 00:00:00

abstract：:Monoclonal mouse hybridoma antibodies were obtained for secreted cellular fibronectin (cFn) from A8387 fibrosarcoma cells. One of them, 52-DH1 (DH), reacted exclusively with cFns but not with plasma Fns (pFns) in immunoblotting and solid-phase EIA. The DH antibody also recognized thermolysin cFn fragments and beta-gal...

journal_title：Journal of cell science

authors： Vartio T,Laitinen L,Närvänen O,Cutolo M,Thornell LE,Zardi L,Virtanen I

更新日期：1987-11-01 00:00:00

abstract：:The relationshio between Con A-receptor mobility and Con A-induced agglutination of Novikoff hepatoma and normal rat liver cells was investigated. Novikoff cells, incubated with fluorescein-labelled Con A at 3 degrees C displayed uniform, ring-like surface fluorescence. Increasing the temperature of the cells to 37 de...

journal_title：Journal of cell science

authors： Mastromarino P,Neri G,Serra A,Walborg EF Jr

更新日期：1980-04-01 00:00:00

abstract：:We use the fungus Ashbya gossypii to investigate how its polar growth machinery is organized to achieve sustained hyphal growth. In slowly elongating hyphae exocyst, cell polarity and polarisome proteins permanently localize as cortical cap at hyphal tips, thus defining the zone of secretory vesicle fusion. In tenfold...

journal_title：Journal of cell science

authors： Köhli M,Galati V,Boudier K,Roberson RW,Philippsen P

更新日期：2008-12-01 00:00:00

abstract：:ARVCF is a novel Armadillo repeat domain protein that is closely related to the catenin p120(ctn). Using new ARVCF monoclonal antibodies, we have found that ARVCF associates with E-cadherin and competes with p120 for interaction with the E-cadherin juxtamembrane domain. ARVCF also localized to the nucleus in some cell...

journal_title：Journal of cell science

authors： Mariner DJ,Wang J,Reynolds AB

更新日期：2000-04-01 00:00:00

abstract：:During the first meiotic prophase, alignment and synapsis of the homologous chromosomes are mediated by the synaptonemal complex. Incorrect assembly of this complex results in cell death, impaired meiotic recombination and formation of aneuploid germ cells. We have identified a novel mouse meiosis-specific protein, TE...

journal_title：Journal of cell science

authors： Hamer G,Gell K,Kouznetsova A,Novak I,Benavente R,Höög C

更新日期：2006-10-01 00:00:00

abstract：:Re-epithelialization after skin wounding requires both migration and hyperproliferation of keratinocytes. Laminin-332 is deposited during migration over the provisional matrix. To investigate the function of the laminin-332 binding integrin alpha3beta1 in wound re-epithelialization, we generated Itga3flox/flox; K14-Cr...

journal_title：Journal of cell science

authors： Margadant C,Raymond K,Kreft M,Sachs N,Janssen H,Sonnenberg A

更新日期：2009-01-15 00:00:00

abstract：:A mutation in the alpha 1-tubulin gene of Chlamydomonas reinhardtii was isolated by using the amiprophos-methyl-resistant mutation apm1-18 as a background to select new mutants that showed increased resistance to the drug. The upA12 mutation caused twofold resistance to amiprophos-methyl and oryzalin, and twofold hype...

journal_title：Journal of cell science

authors： James SW,Silflow CD,Stroom P,Lefebvre PA

更新日期：1993-09-01 00:00:00

abstract：:Ligand-dependent transcriptional regulation by nuclear receptors is believed to be mediated by intermediary factors (TIFs) acting on remodelling of the chromatin structure and/or the activity of the transcriptional machinery. The putative transcriptional mediator TIF1alpha is a nuclear protein kinase that has been ide...

journal_title：Journal of cell science

authors： Remboutsika E,Lutz Y,Gansmuller A,Vonesch JL,Losson R,Chambon P

更新日期：1999-06-01 00:00:00

abstract：:Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a membrane-anchored matrix metalloproteinase (MMP) that is frequently associated with processes involving tissue remodelling and cell migration. We have examined MT1-MMP expression and subcellular distribution as a function of MCF10A mammary epithelial cell migrati...

journal_title：Journal of cell science

authors： Gilles C,Polette M,Coraux C,Tournier JM,Meneguzzi G,Munaut C,Volders L,Rousselle P,Birembaut P,Foidart JM

更新日期：2001-08-01 00:00:00

abstract：:Yeast cells were cultivated at different growth rates in a chemostat by alterations in the flow of the limiting nutrient glucose and in batch cultures where variations in growth rate were achieved by alterations in the composition of nutrients. It was observed that the stage in the cycle at which S-phase was completed...

journal_title：Journal of cell science

authors： Jagadish MN,Carter BL

更新日期：1978-06-01 00:00:00

abstract：:Postsynaptic neuronal dendrites undergo functional and morphological changes in response to pathologically excessive synaptic activation. Although rapid formation of segmental focal swelling (varicosity) is the most prominent hallmark in such excitotoxic injury, little is known about the pathophysiological function of...

journal_title：Journal of cell science

authors： Ikegaya Y,Kim JA,Baba M,Iwatsubo T,Nishiyama N,Matsuki N

更新日期：2001-11-01 00:00:00

abstract：:We have performed a screening analysis of differential gene expression using a defined in vitro model of human capillary tube formation. Gene array, differential display and cDNA library screening were used to identify both known and novel differentially expressed genes. Major findings include: the upregulation and fu...

journal_title：Journal of cell science

authors： Bell SE,Mavila A,Salazar R,Bayless KJ,Kanagala S,Maxwell SA,Davis GE

更新日期：2001-08-01 00:00:00