p53 Induces myocyte apoptosis via the activation of the renin-angiotensin system.

abstract：:Transforming growth factor beta regulates many biological processes including cell motility and invasion. Podosomes are specialized F-actin rich structures found in normal cells, such as osteoclasts and macrophages. Tumor cells often form related structures called invadopodia that are thought to promote invasion and m...

journal_title：Experimental cell research

authors： Mandal S,Johnson KR,Wheelock MJ

更新日期：2008-11-15 00:00:00

abstract：:Inorganic polyphosphate [Poly(P)] may represent a physiological source of phosphate and has the ability to induce bone differentiation in osteoblasts. We previously reported that cytokine-induced matrix metalloproteinase (MMP)-3 accelerates the proliferation of purified odontoblast-like cells. In this study, MMP-3 sma...

journal_title：Experimental cell research

authors： Ozeki N,Hase N,Yamaguchi H,Hiyama T,Kawai R,Kondo A,Nakata K,Mogi M

更新日期：2015-05-01 00:00:00

abstract：:In many animals, the germ line develops from a distinct mitochondria-rich region of embryonic cytoplasm called the germ plasm. However, the protein composition of germ plasm and its formation remain poorly understood, except in Drosophila. Here, we show that Xpat, a recently identified protein component of Xenopus ger...

journal_title：Experimental cell research

authors： Hames RS,Hames R,Prosser SL,Euteneuer U,Lopes CA,Moore W,Woodland HR,Fry AM

更新日期：2008-02-01 00:00:00

abstract：:The structure of a tissue engineering scaffold plays an important role in modulating tissue growth. A novel gelatin-chitosan (Gel-Cs) scaffold with a unique structure produced by three-dimensional printing (3DP) technology combining with vacuum freeze-drying has been developed for tissue-engineering applications. The ...

journal_title：Experimental cell research

authors： Chen H,Liu Y,Jiang Z,Chen W,Yu Y,Hu Q

更新日期：2014-05-01 00:00:00

abstract：:Previous work has suggested that adhesive or cytoskeletal structures alter during epithelial transformation. The purpose of the present studies was to see whether such reorganizations were accompanied by consistent changes in the biophysical characteristics of cells. We used in vitro cell lines from rat liver and resp...

journal_title：Experimental cell research

authors： Heckman CA,Campbell AE,Wetzel B

更新日期：1987-03-01 00:00:00

abstract：:The correct functioning of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is required for normal skin development and homeostasis. Cellular hyperproliferation induced by dysregulation of EGFR is tightly associated with structural and functional defects of hair follicles, skin lesions, and tumorig...

journal_title：Experimental cell research

authors： Chen L,Wang T,Ji X,Ding C,Liang T,Liu X,Lu J,Guo X,Kang Q,Ji Z

更新日期：2019-11-15 00:00:00

abstract：:The progression of cancer cells to highly malignant phenotypes that ultimately invade and metastasize to near and distant sites requires that metastatic cells respond to mitogenic signals in new microenvironments. The successful growth of metastases is due to their ability to respond to local paracrine growth factors ...

journal_title：Experimental cell research

authors： Nicolson GL

更新日期：1993-02-01 00:00:00

abstract：:Tumor angiogenesis and immune response have in common to be cell recognition mechanisms, which are based on specific adhesion molecules and dependent on nitric oxide (NO(•)). The aim of the present study is to deepen the mechanisms of angiogenesis and inflammation regulation by NO(•) to find out the molecular regulati...

journal_title：Experimental cell research

authors： Carreau A,Kieda C,Grillon C

更新日期：2011-01-01 00:00:00

abstract：:The effect of hydrocortisone (HC) on PDGF beta-receptor expression was studied in the human malignant mesothelioma cell line Mero-14. HC was found to induce a time- and dose-dependent increase of PDGF beta-receptor mRNA. Nuclear run off analysis revealed that HC induced increased transcription of the PDGF beta-recepto...

journal_title：Experimental cell research

authors： Versnel MA,Bouts MJ,Langerak AW,van der Kwast TH,Hoogsteden HC,Hagemeijer A,Heldin CH

更新日期：1992-05-01 00:00:00

abstract：:DNA methylation in F9 embryonal carcinoma cells at various stages of retinoic acid-induced differentiation was compared to that in immortalized differentiated derivatives of this cell line. Different repetitive sequences, such as L1 LINE, GAPDH pseudogenes, and major and minor satellite DNA, lost their methylation to ...

journal_title：Experimental cell research

authors： Teubner B,Schulz WA

更新日期：1994-02-01 00:00:00

abstract：:Contraction of 3D collagen matrices by fibroblasts frequently is used as an in vitro model of wound closure. Different iterations of the model - all conventionally referred to as "contraction" - involve different morphological patterns. During floating matrix contraction, cells initially are round without stress fiber...

journal_title：Experimental cell research

authors： Liu Z,Ho CH,Grinnell F

更新日期：2014-08-15 00:00:00

abstract：:Mitochondria are increasingly recognized as key mediators of acute cellular stress responses in asthma. However, the distinct roles of regulators of mitochondrial physiology on allergic asthma phenotypes are currently unknown. The mitochondrial Ca2+ uniporter (MCU) resides in the inner mitochondrial membrane and contr...

journal_title：Experimental cell research

authors： Sebag SC,Koval OM,Paschke JD,Winters CJ,Comellas AP,Grumbach IM

更新日期：2018-01-15 00:00:00

abstract：:By a sequential mutation and selection utilizing N-methyl-N'-nitro-N-nitrosoguanidine as a mutagen, we succeeded in separating a poly(ADP ribose) polymerase-defective mutant clone (Cl-3527) from a mouse L1210 cell clone (Cl-3). The enzyme activity per cell in Cl-3527 cells was only 8% of that in wild type L1210 (CCL 2...

journal_title：Experimental cell research

authors： Yoshihara K,Itaya A,Hironaka T,Sakuramoto S,Tanaka Y,Tsuyuki M,Inada Y,Kamiya T,Ohnishi K,Honma M

更新日期：1992-05-01 00:00:00

abstract：:Paromomycin is an aminocyclitol aminoglycoside antibiotic used for the treatment of leishmaniasis. In view of the central role of mitochondria in cellular energetics and metabolism, its effect on in vivo mitochondrial activities of Leishmania donovani promastigotes-the parasite flagellate form-was investigated. The ap...

journal_title：Experimental cell research

authors： Maarouf M,de Kouchkovsky Y,Brown S,Petit PX,Robert-Gero M

更新日期：1997-05-01 00:00:00

abstract：:Specific mitochondrial incorporation of 10 N-nonyl acridine orange (NAO) is demonstrated by subcellular fractionation of rat hepatocytes. Moreover, comparative studies with NAO and rhodamine 123 (Rh 123) prove that acridine orange-derivative uptake is independent of transmembrane mitochondrial potential, a property al...

journal_title：Experimental cell research

authors： Leprat P,Ratinaud MH,Maftah A,Petit JM,Julien R

更新日期：1990-01-01 00:00:00

abstract：:The effect of 1 microM antimycin on the proliferative properties, metabolism and basic cell composition of Ehrlich ascites tumour cells cultured in the second in vitro passage was studied. Continuous drug exposure of asynchronous cells caused rapid cessation of cell growth, characterized by the cell number and DNA, RN...

journal_title：Experimental cell research

authors： Löffler M

更新日期：1985-03-01 00:00:00

abstract：:The phenotypic transition of smooth muscle cells (SMC) from a contractile to a synthetic state appears to be an early event in the pathogenesis of atherosclerosis. We examined the effects of extracellular matrix components on the phenotypic modulation of rabbit arterial SMC in primary culture by flow cytometry. The re...

journal_title：Experimental cell research

authors： Yamamoto M,Yamamoto K,Noumura T

更新日期：1993-01-01 00:00:00

abstract：:Porcine brain microvascular endothelial cells (PBMEC) were isolated from fresh brains by several enzymatic digestion steps followed by a gradient centrifugation. Cells of the primary culture were transfected with pRNS-1, encoding for the small and large T-antigens of SV 40, by means of lipofection. After selection wit...

journal_title：Experimental cell research

authors： Teifel M,Friedl P

更新日期：1996-10-10 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are frequently used as a therapeutic, but reliable imaging technique to longitudinally evaluate the engraftment of transplanted cells is inadequate. For magnetic resonance imaging (MRI), it is essential to understand the technical competence of in vitro stem cells labeling with iron oxide...

journal_title：Experimental cell research

authors： Mishra SK,Khushu S,Gangenahalli G

更新日期：2017-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are non-immunogenic, multipotent cells with at least trilineage differentiation potential. They promote wound healing, improve regeneration of injured tissue, and mediate numerous other health effects. MSCs migrate to sites of injury and stimulate repair either through direct differentiat...

journal_title：Experimental cell research

authors： Naaldijk Y,Johnson AA,Ishak S,Meisel HJ,Hohaus C,Stolzing A

更新日期：2015-10-15 00:00:00

abstract：:Alexander disease (AxD) is a rare neurodegenerative disorder characterized by large cytoplasmic aggregates in astrocytes and myelin abnormalities and caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), the main intermediate filament protein in astrocytes. We tested the effects of ...

journal_title：Experimental cell research

authors： Mignot C,Delarasse C,Escaich S,Della Gaspera B,Noé E,Colucci-Guyon E,Babinet C,Pekny M,Vicart P,Boespflug-Tanguy O,Dautigny A,Rodriguez D,Pham-Dinh D

更新日期：2007-08-01 00:00:00

abstract：:Autophagy has been shown to be critically associated with the central mechanisms underlying Parkinson's disease (PD), while the mechanisms contributing to the imbalance of autophagy remain unclear. Small nucleolar RNA host gene 1 (SNHG1), a well-studied long noncoding RNA, has been reported to be significantly increas...

journal_title：Experimental cell research

authors： Qian C,Ye Y,Mao H,Yao L,Sun X,Wang B,Zhang H,Xie L,Zhang H,Zhang Y,Zhang S,He X

更新日期：2019-11-01 00:00:00

abstract：:The phosphorylation state of the CD18-chain of beta 2-integrins have been shown not to mediate changes in the avidity of these receptors (i.e., inside-out signaling); however, no alternative functional significance has been proposed. Our study focused on how changes in the phosphorylation state of beta 2-integrin-rece...

journal_title：Experimental cell research

authors： Hellberg C,Eierman D,Sjölander A,Andersson T

更新日期：1995-03-01 00:00:00

abstract：:Polyamines affect nucleosome oligomerization and DNA conformation in vitro, yet little information exists regarding the influence of naturally synthesized polyamines on mammalian chromatin. Capitalizing on the relative inefficiency of a moderate ionic strength extraction buffer to dissociate histones, we obtained evid...

journal_title：Experimental cell research

authors： Hobbs CA,Paul BA,Gilmour SK

更新日期：2003-11-01 00:00:00

abstract：:The purpose of the present study was to investigate the influence of the actin cytoskeleton on gap junctional intercellular communication (GJIC) in cultured astrocytes. This report describes an decrease of GJIC following microinjection of anti-actin antibodies or cytochalasin D treatment. Dye transfer of microinjected...

journal_title：Experimental cell research

authors： Theiss C,Meller K

更新日期：2002-12-10 00:00:00

abstract：:Uptake and metabolism of thymidine and adenosine have been studied in embryos of the sea urchin Strongylocentrotus purpuratus. Uptake of these nucleosides is found to be mutually competitive, with the Km for uptake of thymidine similar to its Ki for inhibition of adenosine uptake and vice versa. The metabolic studies ...

journal_title：Experimental cell research

authors： Schneider EG,Whitten DJ

更新日期：1987-01-01 00:00:00

abstract：:The effect of the physiological vitamin D metabolite 24R, 25-dihydroxyvitamin D3 [24R,25(OH)2D3] on human osteoblastic cells was assessed. Physiological concentrations (10(-9)-10(-8) M) of 24R, 25(OH)2D3 significantly increased the cyclic guanosine 5'-monophosphate (cGMP) content in the human osteoblastic cells by app...

journal_title：Experimental cell research

authors： Yamamoto T,Ozono K,Shima M,Yamaoka K,Okada S

更新日期：1998-10-10 00:00:00

abstract：:Pancreatic cancer is characterized by aggressive local invasion and early metastasis formation. Active migration of the pancreatic cancer cells is essential for these processes. We have shown previously that the pancreatic cancer cells lines CFPAC1 and IMIM-PC2 show high migratory activity, and we have investigated he...

journal_title：Experimental cell research

authors： Stock AM,Hahn SA,Troost G,Niggemann B,Zänker KS,Entschladen F

更新日期：2014-08-15 00:00:00

abstract：:An in vitro system has been employed to study the apoptotic mechanisms in the AK-5 tumor which is a spontaneously regressing rat histiocytoma. Cytosolic extracts of tumor cells primed for apoptosis using dexamethasone and immune serum from tumor-regressing animals were able to induce apoptosis in intact nuclei and rep...

journal_title：Experimental cell research

authors： Anjum R,Khar A

更新日期：1997-11-01 00:00:00

abstract：:The alpha 3 beta 1 integrin has been implicated as a receptor for several matrix components, including collagen, fibronectin, and laminins. The function of alpha 3 beta 1 seems to be very versatile involving cell adhesion to or migration on ECM, establishment of cell-cell contacts in aggregates, as well as linkage to ...

journal_title：Experimental cell research

authors： Lichtner RB,Howlett AR,Lerch M,Xuan JA,Brink J,Langton-Webster B,Schneider MR

更新日期：1998-05-01 00:00:00