The early amniocentesis study: a randomized clinical trial of early amniocentesis and midtrimester amniocentesis. II. Evaluation of procedure details and neonatal congenital anomalies.

Abstract:

:The present study provides detailed neonatal and congenital malformation follow-up from 695 women enrolled in a prospective randomized multicenter study comparing the safety and accuracy of early (11-12 weeks of gestation) and midtrimester amniocentesis (15-16 weeks of gestation). No differences were found for total pregnancy loss (difference 0.4%; CI -3.6 to 4.4%), obstetrical or neonatal outcome. The incidence of congenital anomalies was 2.4 and 2.6% for the early amniocentesis and midtrimester amniocentesis groups, respectively. Respiratory problems were present in 2.1 and 1.6%, respectively. Musculoskeletal problems were present in 0.9 and 2.4%, respectively. It must be emphasized that before early amniocentesis can be considered as an alternative to midtrimester amniocentesis or chorionic villus sampling, careful evaluation of any fetal effects must be considered and further large randomized trials are necessary.

journal_name

Fetal Diagn Ther

authors

Wilson RD,Johnson J,Windrim R,Dansereau J,Singer J,Winsor EJ,Kalousek D

doi

10.1159/000264440

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

97-101

issue

2

eissn

1015-3837

issn

1421-9964

journal_volume

12

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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