Factors involved in cardiac autonomic neuropathy in diabetic patients.

Abstract:

:The role cardiac autonomic neuropathy (CAN) plays in diabetes is not well known. The aim of this study was to identify the factors involved in CAN in diabetic patients. One hundred patients, 44 insulin-dependent (IDDM) and 56 non-insulin-dependent (NIDDM), were investigated, using five standard tests. Three of these tests were for parasympathetic control (cardiac response to the lying-to-standing, deep breathing, and Valsalva tests), and the other two measured sympathetic control (testing for orthostatic hypotension and evaluating heart and blood pressure response to the handgrip test). Results were compared to those found in a series of 40 healthy volunteers. An age-adjusted comparison with the controls, showed that 34 patients had one abnormal parasympathetic test, 23 had two, and 6 patients had three. Cardiac parasympathetic neuropathy was thus present in 63% of the patients. The handgrip test was completed by 84 diabetic patients. There was evidence of orthostatic hypotension and/or an abnormal cardiac response to the handgrip in 15 of these patients, who all had a parasympathetic abnormality as well. There was no significant association between the type of diabetes and the presence of CAN. The duration of diabetes was significantly longer in patients with CAN (9.3 +/- 0.9 years) (p < 0.01) than in those with all three parasympathetic tests normal (5.8 +/- 0.9 years) (p < 0.01). The HbA1c level was also higher in patients with CAN than in those with three normal parasympathetic tests (9.95 +/- 0.35% versus 8.17 +/- 0.42%, p < 0.005). There was a significant association between the presence of retinopathy, observed by angiofluorography, and the presence of peripheral neuropathy confirmed by the electrophysiological investigation and the presence of CAN (p < 0.001). However, more than half the patients without retinopathy or nephropathy had CAN, and 11 of the 31 patients with a normal electrophysiological investigation also had CAN. Eighteen patients (6 IDDM) without retinopathy and nephropathy, who had been diabetic for less than 2 years, also had CAN. This study shows that CAN occurs early and is frequently found in a population of unselected diabetic patients. Metabolic factors may play an important role in its occurrence. CAN is significantly associated with the presence of retinopathy, which suggests that an impairment of autonomic peripheral blood flow control might be a contributing factor in the formation of microvascular lesions.

authors

Valensi P,Huard JP,Giroux C,Attali JR

doi

10.1016/s1056-8727(97)00005-6

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

180-7

issue

3

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(97)00005-6

journal_volume

11

pub_type

杂志文章
  • Overweight and obese children with optimal control in the T1D Exchange Registry: How are they different from lean children with optimal control?

    abstract:AIMS:Increased adiposity is a risk factor for suboptimal diabetes control and cardiovascular disease (CVD) complications. Our goal was to identify modifiable behavioral characteristics of overweight and obese pediatric patients with type 1 diabetes mellitus (T1DM) who achieve optimal glycemic control and to evaluate th...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2019.107513

    authors: Flokas ME,Zeymo A,Mete M,Anhalt H,Rother KI,Gourgari E

    更新日期:2020-04-01 00:00:00

  • Risk characterization for urinary tract infections in subjects with newly diagnosed type 2 diabetes.

    abstract:AIM:To evaluate the risk of urinary tract infections (UTI) in subjects with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS:Subjects aged ≥18years and diagnosed with T2DM between 1/1/10 and 12/31/10 were identified using the MarketScan® databases, which are representative of the commercially insured US popula...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2014.06.009

    authors: Fu AZ,Iglay K,Qiu Y,Engel S,Shankar R,Brodovicz K

    更新日期:2014-11-01 00:00:00

  • What factors influence uptake of retinal screening among young adults with type 2 diabetes? A qualitative study informed by the theoretical domains framework.

    abstract:AIMS:Young adults with type 2 diabetes (T2D, 18-39years) face increased risk of vision loss from diabetic retinopathy (DR). Retinal screening is essential to detect DR, yet screening rates for this group are low and little is known about the underlying factors influencing this important behavior. Using the theoretical ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2017.02.020

    authors: Lake AJ,Browne JL,Rees G,Speight J

    更新日期:2017-06-01 00:00:00

  • All-cause and cardiovascular mortality risk in U.S. adults with and without type 2 diabetes: Influence of physical activity, pharmacological treatment and glycemic control.

    abstract:AIMS:This study determined the joint association between physical activity, pharmacotherapy, and HbA1c control on all-cause and cardiovascular disease (CVD) mortality risk in adults with and without type 2 diabetes (T2D). METHODS:12,060 adults from NHANES III and NHANES continuous (1999-2002) surveys were used. Cox pr...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2013.06.005

    authors: Brown RE,Riddell MC,Macpherson AK,Canning KL,Kuk JL

    更新日期:2014-05-01 00:00:00

  • Evaluation of urinary Tamm-Horsfall protein in post-menopausal diabetic women.

    abstract::Tamm-Horsfall protein (THP), a glycoprotein produced in the thick ascending limb (TAL) and the early distal convoluted tubule (DCT), is normally excreted in large amounts in urine. Urinary THP may be a useful marker for renal damage. The goal of this research project was to determine the THP excretion in control and d...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(99)00046-x

    authors: Below AA,Chakraborty J,Khuder SH,Haselhuhn GD

    更新日期:1999-07-01 00:00:00

  • Association between dipstick hematuria and decline in estimated glomerular filtration rate among Japanese patients with type 2 diabetes: A prospective cohort study [Diabetes Distress and Care Registry at Tenri (DDCRT 14)].

    abstract:AIMS:To assess the association between dipstick hematuria and estimated glomerular filtration rate (eGFR) decline in Japanese patients with type 2 diabetes. METHODS:Longitudinal data were obtained from 3068 Japanese patients with type 2 diabetes. To assess the independent association between dipstick hematuria and eGF...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2017.04.016

    authors: Mashitani T,Hayashino Y,Okamura S,Kitatani M,Furuya M,Iburi T,Tsujii S,Ishii H,Diabetes Distress and Care Registry at Tenri Study Group.

    更新日期:2017-07-01 00:00:00

  • Insulin resistance since early adulthood and appendicular lean mass in middle-aged adults without diabetes: 20 years of the CARDIA study.

    abstract:AIMS:To determine the association between 20-year trajectories in insulin resistance (IR) since young adulthood and appendicular lean mass (ALM) at middle-age in adults without diabetes. METHODS:A prospective cohort study was designed among young and middle-aged US men (n = 925) and women (n = 1193). Fasting serum glu...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2018.09.011

    authors: Zhong VW,Bancks MP,Schreiner PJ,Lewis CE,Steffen LM,Meigs JB,Schrader LA,Schorr M,Miller KK,Sidney S,Carnethon MR

    更新日期:2019-01-01 00:00:00

  • Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy.

    abstract::To determine whether inflammatory cytokines are increased in proliferative diabetic retinopathy. We measured concentrations of interleukin-6, 8 (IL-6, 8) and tumor necrosis factor (TNF)-alpha by enzyme-linked immunosorbent assay (ELISA) in vitreous and serum from 47 patients with proliferative diabetic retinopathy and...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(01)00155-6

    authors: Yuuki T,Kanda T,Kimura Y,Kotajima N,Tamura J,Kobayashi I,Kishi S

    更新日期:2001-09-01 00:00:00

  • Combined exercise and visual gaze training improves stepping accuracy in people with diabetic peripheral neuropathy.

    abstract:INTRODUCTION:Patients with diabetes and diabetic peripheral neuropathy (DPN) place their feet with less accuracy whilst walking, which may contribute to the increased falls-risk. This study examines the effects of a multi-faceted intervention on stepping accuracy, in patients with diabetes and DPN. METHODS:Forty parti...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2019.07.001

    authors: Handsaker JC,Brown SJ,Petrovic M,Bowling FL,Rajbhandari S,Marple-Horvat DE,Boulton AJM,Reeves ND

    更新日期:2019-10-01 00:00:00

  • Social adaptability index predicts overall mortality in patients with diabetes.

    abstract:BACKGROUND:A quantifiable assessment of socioeconomic status and its bearing on clinical outcome in patients with diabetes is lacking. The social adaptability index (SAI) has previously been validated in the general population and in patients with chronic kidney disease, including those on dialysis and with kidney tran...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2011.12.002

    authors: Goldfarb-Rumyantzev AS,Rout P,Sandhu GS,Barenbaum A,Patibandla BK,Narra A,Chawla V,Williams M

    更新日期:2012-01-01 00:00:00

  • Effects of a synthetic retinoid on skin structure, matrix metalloproteinases, and procollagen in healthy and high-risk subjects with diabetes.

    abstract:BACKGROUND:In diabetes, foot ulceration may result from increased skin fragility. Retinoids can reverse some diabetes-induced deficits of skin structure and function, but their clinical utility is limited by skin irritation. The effects of diabetes and MDI 301, a nonirritating synthetic retinoid, and retinoic acid have...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2011.10.002

    authors: Zeng W,Tahrani A,Shakher J,Varani J,Hughes S,Dubb K,Stevens MJ

    更新日期:2011-11-01 00:00:00

  • Paraoxonase 1 gene polymorphisms concerning non-insulin-dependent diabetes mellitus nephropathy in hemodialysis patients.

    abstract:AIMS:Data on involvement of paraoxonase 1 gene (PON1) in non-insulin-dependent diabetes mellitus (NIDDM) nephropathy are scarce. We investigated PON1 polymorphisms concerning end-stage NIDDM nephropathy and atherosclerotic complications in NIDDM nephropathy patients treated with hemodialysis (HD). METHODS:In NIDDM nep...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2020.107687

    authors: Grzegorzewska AE,Ostromecka K,Adamska P,Mostowska A,Warchoł W,Jagodziński PP

    更新日期:2020-11-01 00:00:00

  • Plerixafor stimulates adhesive activity and endothelial regeneration of endothelial progenitor cells via elevating CXCR7 expression.

    abstract:AIMS:To assess the effects of plerixafor on function and endothelial regeneration of endothelial progenitor cells (EPCs). METHODS:The proliferation and adhesion capacity of EPCs were evaluated in vitro. Furthermore, the expression levels of CXC chemokine receptor-7 (CXCR7) were detected before and after treatment with...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2020.107654

    authors: Jiang C,Li R,Ma X,Hu H,Wei L,Zhao J

    更新日期:2020-10-01 00:00:00

  • Assessing cardiovascular autonomic neuropathy in diabetes mellitus: how many tests to use?

    abstract::The aim was to evaluate the relative importance of an established battery of five function tests used in the assessment of cardiovascular autonomic neuropathy (CAN) in diabetes employing spectral analysis of heart rate variability (HRV) as the reference test. In a population-based sample of 178 diabetic persons and 19...

    journal_title:Journal of diabetes and its complications

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1056-8727(00)00062-3

    authors: May O,Arildsen H

    更新日期:2000-01-01 00:00:00

  • Resistance of retinal inflammatory mediators to suppress after reinstitution of good glycemic control: novel mechanism for metabolic memory.

    abstract::Diabetic retinopathy resists arrest of its progression after reestablishment of good glycemic control that follows a profound period of poor glycemic control. The objective of this study was to elucidate the role of inflammation in the resistance of retinopathy to arrest after termination of hyperglycemia. Streptozoto...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2008.10.002

    authors: Chan PS,Kanwar M,Kowluru RA

    更新日期:2010-01-01 00:00:00

  • The potential of sodium glucose cotransporter 2 (SGLT2) inhibitors to reduce cardiovascular risk in patients with type 2 diabetes (T2DM).

    abstract::Type 2 diabetes mellitus (T2DM) significantly increases morbidity and mortality from cardiovascular disease (CVD). Treatments for patients with T2DM have the potential to reduce cardiovascular (CV) risk. This review focuses on the potential of a new class of antidiabetic agents, the sodium glucose cotransporter 2 (SGL...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdiacomp.2012.12.004

    authors: Basile JN

    更新日期:2013-05-01 00:00:00

  • Impact of comorbid conditions and race/ethnicity on glycemic control among the US population with type 2 diabetes, 1988-1994 to 1999-2004.

    abstract:OBJECTIVE:To measure trends in glycemic control in type 2 diabetes in the United States from 1988-1994 to 1999-2004 and to identify factors influencing glycemic control, including the presence of comorbid conditions and race/ethnicity. METHODS:Participants in the National Health and Nutrition Examination Surveys (1988...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2009.07.001

    authors: Suh DC,Choi IS,Plauschinat C,Kwon J,Baron M

    更新日期:2010-11-01 00:00:00

  • Urinary excretion rate of NC1 and Tamm-Horsfall protein in the microalbuminuric type I diabetic patient.

    abstract::Fifty-six type I diabetic patients with microalbuminuria (albumin excretion rate 20-200 micrograms/min) were characterized as to sex, age, duration of diabetes, smoking habits, blood pressure, glomerular filtration rate, urinary NC1 (the carboxy-terminal domain of collagen IV), and Tamm-Horsfall protein excretion rate...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/1056-8727(94)90055-8

    authors: Torffvit O,Agardh CD

    更新日期:1994-04-01 00:00:00

  • Prognostic indices for intra-hospital mortality in Nigerian diabetic NIDDM patients. Role of gender and hypertension.

    abstract::Hypertension and diabetes mellitus are independently associated with a high rate of target organ complications, which is particularly accentuated in the Negroid race. The aims of this study were to evaluate the mortality associated with diabetes mellitus and concurrent hypertension and diabetes mellitus in indigenous ...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(00)00069-6

    authors: Kolawole BA,Ajayi AA

    更新日期:2000-03-01 00:00:00

  • Differential effects of low-carbohydrate and low-fat diets on inflammation and endothelial function in diabetes.

    abstract:OBJECTIVE:To characterize acute (postprandial) and chronic (after a 6-month period of weight loss) effects of a low-carbohydrate vs. a low-fat diet on subclinical markers of cardiovascular disease (CVD) in adults with type 2 diabetes. DESIGN:At baseline and 6 months, measures of C-reactive protein (CRP), interleukin-6...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jdiacomp.2011.08.001

    authors: Davis NJ,Crandall JP,Gajavelli S,Berman JW,Tomuta N,Wylie-Rosett J,Katz SD

    更新日期:2011-11-01 00:00:00

  • Periodontal status of diabetics compared with nondiabetics: a meta-analysis.

    abstract:BACKGROUND:This meta-analysis was conducted to assess the association between diabetes mellitus and periodontal diseases by comparing the extent and severity of periodontal diseases between diabetics and nondiabetics. METHODS:A literature search was performed using MEDLINE database for published studies from January 1...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jdiacomp.2005.05.006

    authors: Khader YS,Dauod AS,El-Qaderi SS,Alkafajei A,Batayha WQ

    更新日期:2006-01-01 00:00:00

  • The prevalence of incipient tubular dysfunction, but not of glomerular dysfunction, is increased in patients with diabetes onset in childhood.

    abstract::The study investigated the prevalence of incipient renal dysfunction in two cohorts with identical duration of type I diabetes but with childhood or adult onset of the disease. The pattern of glomerular (albumin, alb) and tubular (alpha(1)-microglobulin, alpha(1)-m, and N-acetyl-beta-D-glucosaminidase, NAG) urinary pr...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(99)00055-0

    authors: Kordonouri O,Kahl A,Jörres A,Hopfenmüller W,Müller C,Danne T

    更新日期:1999-09-01 00:00:00

  • Exenatide improves diastolic function and attenuates arterial stiffness but does not alter exercise capacity in individuals with type 2 diabetes.

    abstract:BACKGROUND:Exercise is recommended as a cornerstone of treatment for type 2 diabetes mellitus (T2DM), however, it is often poorly adopted by patients. Even in the absence of apparent cardiovascular disease, persons with T2DM have an impaired ability to carry out maximal and submaximal exercise and these impairments are...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jdiacomp.2016.10.003

    authors: Scalzo RL,Moreau KL,Ozemek C,Herlache L,McMillin S,Gilligan S,Huebschmann AG,Bauer TA,Dorosz J,Reusch JE,Regensteiner JG

    更新日期:2017-02-01 00:00:00

  • Skeletal muscle lipoprotein-lipase activity in insulin-dependent diabetic patients with and without albuminuria.

    abstract::In patients with insulin-dependent diabetes mellitus (IDDM), albuminuria reflects widespread vascular dysfunction. Albuminuria has been associated to defects of heparan sulfate proteoglycan (HSPG) within the extracellular matrix. Our hypothesis is that loss of HSPG in vascular walls reduces the HSPG-bound lipoprotein-...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/s1056-8727(96)00048-7

    authors: Hansen PM,Jensen T,Egeberg J,Lithell H,Kofoed-Enevoldsen A,Deckert T

    更新日期:1997-07-01 00:00:00

  • Prevalence of symptoms suggestive of gastroparesis in a cohort of patients with diabetes mellitus.

    abstract:AIMS:To estimate the prevalence of symptoms suggestive of gastroparesis and their association to clinical and demographic data in a large population of patients with diabetes mellitus and in the general population in Israel. METHODS:A cross-sectional survey of type 2 diabetic patients treated in community settings was...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2013.02.004

    authors: Dickman R,Kislov J,Boaz M,Ron Y,Beniashvili Z,Raz I,Baigel I,Niv Y,Wainstein J

    更新日期:2013-07-01 00:00:00

  • Stratifying healthcare costs using the Diabetes Complication Severity Index.

    abstract:OBJECTIVE:We aim to determine whether healthcare costs for patients diagnosed with Type 2 Diabetes Mellitus (T2DM) are associated with the severity of diabetes complications as measured by the Diabetes Complication Severity Index (DCSI). METHODS:Retrospective cohort analysis was performed on a 2007 primary care cohort...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2012.02.004

    authors: Wu CX,Tan WS,Toh MP,Heng BH

    更新日期:2012-03-01 00:00:00

  • Community-acquired infections in type 2 diabetic patients and their nondiabetic partners. The Fremantle Diabetes Study.

    abstract:AIMS:The aim of this study was to investigate the association between Type 2 diabetes and community-acquired infections. METHODS:We recruited 68 patients (mean+/-S.D. age=64.9+/-9.1 years; 57.4% males) from a community-based cohort and their nondiabetic partners (age=63.8+/-9.9 years; mean relationship duration=37.3+/...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2005.03.003

    authors: Davis TM,Weerarathne T,Foong Y,Mason C,Davis WA

    更新日期:2005-09-01 00:00:00

  • Hepatitis C infection and diabetes.

    abstract::Since the discovery of the hepatitis C virus (HCV) in 1989, attention has been paid to the association of chronic HCV infection and the development of diabetes. The risk factors for diabetes include older age, HCV genotype 3, severe liver fibrosis, family history of diabetes, and liver/kidney transplantation. Emerging...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章,评审

    doi:10.1016/j.jdiacomp.2006.01.001

    authors: Noto H,Raskin P

    更新日期:2006-03-01 00:00:00

  • Albuminuria rather than glomerular filtration rate is associated with vascular endothelial function in patients with type 2 diabetes.

    abstract:AIMS:Albuminuria and reduced glomerular filtration rate (GFR) are manifestations of diabetic kidney disease and are both shown to be associated with cardiovascular outcomes. However, the differential association of albuminuria and reduced GFR with endothelial dysfunction, an early feature of atherosclerotic vascular da...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2020.107702

    authors: Kakutani Y,Morioka T,Mori K,Yamazaki Y,Ochi A,Kurajoh M,Fukumoto S,Shioi A,Shoji T,Inaba M,Emoto M

    更新日期:2020-12-01 00:00:00

  • The 1h post glucose value best predicts future dysglycemia among normal glucose tolerance subjects.

    abstract:AIM:To analyse the OGTT glycemic parameters - fasting, 1h and 2h plasma glucose values singly and in various combinations; with respect to their prediction of future dysglycemia in subjects with normal glucose tolerance (NGT). METHODS:Electronic medical records of individuals who underwent an OGTT between 1991 and 201...

    journal_title:Journal of diabetes and its complications

    pub_type: 杂志文章

    doi:10.1016/j.jdiacomp.2017.07.017

    authors: Sai Prasanna N,Amutha A,Pramodkumar TA,Anjana RM,Venkatesan U,Priya M,Pradeepa R,Mohan V

    更新日期:2017-11-01 00:00:00