The in vitro motility activity of beta-cardiac myosin depends on the nature of the beta-myosin heavy chain gene mutation in hypertrophic cardiomyopathy.

abstract：:ADF/cofilins disassemble the actin filament and contribute to a wide range of actin dynamics. These proteins are regulated by several factors, including phosphorylation, pH and mechanical forces. Although the cofilin-decorated actin filament structure was published recently, the mechanisms of these regulating factors ...

journal_title：Journal of muscle research and cell motility

authors： Narita A

更新日期：2020-03-01 00:00:00

abstract：:The aim of the present study was to examine the temperature dependence of active force in lengthening and shortening muscle. Experiments were done, in vitro, on bundles of intact fibres (fibre length L(0) ~2 mm; sarcomere length ~2.5 μm) isolated from a rat fast muscle (flexor hallucis brevis) and a ramp length change...

journal_title：Journal of muscle research and cell motility

authors： Roots H,Pinniger GJ,Offer GW,Ranatunga KW

更新日期：2012-10-01 00:00:00

abstract：:Although a substantial literature exists on the in vitro polymerization of purified myosin, little is known about native thick filament assembly, remodeling or turnover. We have recently described a cell-free system (Bouche et al., 1988) to examine the interactions between thick filaments and soluble, newly synthesize...

journal_title：Journal of muscle research and cell motility

authors： Goldfine SM,Einheber S,Fischman DA

更新日期：1991-04-01 00:00:00

abstract：:There is evidence to suggest that 8 nm calcium transport particles in the sarcoplasmic reticulum are involved in the regulation of twitch properties in adult muscles. We have studied ultrastructural characteristics of the sarcoplasmic reticulum in relation to previously defined physiological changes that take place in...

journal_title：Journal of muscle research and cell motility

authors： Gauthier GF,Hobbs AW

更新日期：1986-04-01 00:00:00

abstract：:We examined the temperature dependence of muscle and non-muscle myosin (heavy meromyosin, HMM) with in vitro motility and actin-activated ATPase assays. Our results indicate that myosin V (MV) has a temperature dependence that is similar in both ATPase and motility assays. We demonstrate that skeletal muscle myosin (S...

journal_title：Journal of muscle research and cell motility

authors： Yengo CM,Takagi Y,Sellers JR

更新日期：2012-12-01 00:00:00

abstract：:Under muscle disuse conditions decrease of expression of MyHC of slow type, and sometimes of type IIa, as well as upregulation of expression of IIb and IId/x isoforms were observed. Through dephosphorylation and entry of NFAT molecules to the nucleus calcineurin/NFATc1 signaling pathway promotes upregulation of the sl...

journal_title：Journal of muscle research and cell motility

authors： Lomonosova YN,Turtikova OV,Shenkman BS

更新日期：2016-04-01 00:00:00

abstract：:The effects of a ramp stretch (amplitude <6% muscle fibre length (L0), speed < 13L0 s(-1)) on twitch tension and twitch tension re-development were examined in intact mammalian (rat) fast and slow muscle fibre bundles. The experiments were done in vitro at 20 degrees C and at an initial sarcomere length of 2.68 microm...

journal_title：Journal of muscle research and cell motility

authors： Mutungi G,Ranatunga KW

更新日期：2001-01-01 00:00:00

abstract：:Muscle development involves a complex sequence of time and spatially regulated cellular events leading to the formation of highly specialised syncytial muscle cells displaying a common feature, the capacity of contraction. Analyses of mechanisms controlling muscle development reveals that the main steps of muscle form...

journal_title：Journal of muscle research and cell motility

authors： Maqbool T,Jagla K

更新日期：2007-01-01 00:00:00

abstract：:Hodges and his colleagues identified a 12 amino acid fragment of troponin I (TnI-ip) that inhibits Ca(2+)-activated force and reduces the effectiveness Ca(2+) as an activator. To understand the role of troponin C (TnC) in the extended cooperative interactions of thin filament activation, we compared the effect of TnI-...

journal_title：Journal of muscle research and cell motility

authors： Schachat F,Brandt PW

更新日期：2013-05-01 00:00:00

abstract：:The loss of muscle force and power during fatigue from intense contractile activity is associated with, and likely caused by, elevated levels of phosphate ([Formula: see text]) and hydrogen ions (decreased pH). To understand how these deficits in muscle performance occur at the molecular level, we used direct measurem...

journal_title：Journal of muscle research and cell motility

authors： Jarvis K,Woodward M,Debold EP,Walcott S

更新日期：2018-08-01 00:00:00

abstract：:The L-type Ca2+ channel in skeletal muscle (alpha1S) is essential for excitation-contraction (EC) coupling. Previous studies using chimeras composed of alpha1S together with alpha1C or alpha1M demonstrated the importance of the alpha1S II-III loop and of a smaller subdomain (residues 720-764; 'ECC') in skeletal EC cou...

journal_title：Journal of muscle research and cell motility

authors： Wilkens CM,Beam KG

更新日期：2003-01-01 00:00:00

abstract：:Guinea-pig soleus muscles were denervated and electrically stimulated for periods of 43 to 66 days. Stimuli were in 1 s bursts of 40 Hz pulses, repeated every 5 min. Other guinea-pigs were denervated for 82 days without stimulation and, in a third group, the soleus muscle was necrotized and allowed to regenerate witho...

journal_title：Journal of muscle research and cell motility

authors： Lewis DM,al-Amood WS,Schmalbruch H

更新日期：1997-10-01 00:00:00

abstract：:The properties of extraocular muscles (EOMs) are quite different from those of the trunk and limb. Here we show that there is a novel pattern of troponin T (TnT) expression in EOMs which most likely contributes to the fine control of ocular movement and may reflect their innervation by cranial motoneurons. Three regio...

journal_title：Journal of muscle research and cell motility

authors： Briggs MM,Jacoby J,Davidowitz J,Schachat FH

更新日期：1988-06-01 00:00:00

abstract：:The length dependency of the sensitivity to activators of the smooth muscle of different blood vessels is not yet fully understood. Muscle preparations of the aorta, the femoral artery and the portal vein of the rabbit were investigated for the length dependency of the sensitivity to phenylephrine and calcium in both ...

journal_title：Journal of muscle research and cell motility

authors： Van Heijst BG,De Wit E,Van der Heide UA,Blangé T,Jongsma HJ,De Beer EL

更新日期：1999-01-01 00:00:00

abstract：:Long-(SL > 6 microns) and short-sarcomere (SL < 4 microns) fibres were isolated from the claw muscle of the yabby (Cherax destructor) during limb regeneration and at different stages of the moult cycle. Long-sarcomere fibres were more susceptible to the changes resulting from the moult-induced atrophy compared with th...

journal_title：Journal of muscle research and cell motility

authors： West JM,Humphris DC,Stephenson DG

更新日期：1995-06-01 00:00:00

abstract：:The giant molecule titin (also called connectin) provides an elastic connection in the I-band between the Z-disk and A-band of striated muscle. This region is assembled in a tissue-specific way by extensive differential splicing events. We have raised monoclonal antibodies against the two N2-line isoforms of titin and...

journal_title：Journal of muscle research and cell motility

authors： Gautel M,Lehtonen E,Pietruschka F

更新日期：1996-08-01 00:00:00

abstract：:temporaria (0.9-2.5degrees C) were stimulated to produce a 1 s isometric tetanus at regular intervals until constant mechanical responses were attained. Various degrees of force depression ("fatigue") were produced by decreasing the contraction interval from 30 or 15 min (control to 120, 60, 30 and 15s, respectively. ...

journal_title：Journal of muscle research and cell motility

authors： Edman KA,Mattiazzi AR

更新日期：1981-09-01 00:00:00

abstract：:Skeletal muscle hypertrophy is a result of increased load, such as functional and stretch-overload. Activation of satellite cells and proliferation, differentiation and fusion are required for hypertrophy of overloaded skeletal muscles. On the contrary, a dramatic loss of skeletal muscle mass determines atrophy settin...

journal_title：Journal of muscle research and cell motility

authors： Cassano M,Quattrocelli M,Crippa S,Perini I,Ronzoni F,Sampaolesi M

更新日期：2009-12-01 00:00:00

abstract：:Mechanical properties of myofibrillar bundles from single chemically skinned fibres from the superficial abdominal flexor muscle of the Norway lobster Nephrops norvegicus were measured, and the protein content of these fibres was analysed by SDS-PAGE. Two slow fibre phenotypes (S1, S2) were distinguished on the basis ...

journal_title：Journal of muscle research and cell motility

authors： Holmes JM,Hilber K,Galler S,Neil DM

更新日期：1999-04-01 00:00:00

abstract：:In frog semitendinosus muscle the descending limb of the length-tension curve is shifted rightward relative to that of tibialis anterior. Both the plateau right corner and the zero-force intercept are equally shifted. To investigate the reason for this shift, we compared filament lengths in the two muscles. Single fib...

journal_title：Journal of muscle research and cell motility

authors： Trombitás K,Frey L,Pollack GH

更新日期：1993-04-01 00:00:00

abstract：:Troponin T (TnT) is one of the muscle regulatory proteins and is thought to be related to unique contractile properties in diverse muscles and also to myogenesis. The expression of TnT isoforms in the chicken wing muscles was investigated by two-dimensional gel electrophoresis and immunoblotting with an antiserum agai...

journal_title：Journal of muscle research and cell motility

authors： Miyazaki JI,Akutsu S,Satow N,Hirao C,Yao Y

更新日期：2001-01-01 00:00:00

abstract：:Using a variety of techniques, we have demonstrated the presence of at least two fibre types in Limulus median telson levator muscle. By light and electron microscopy, large (2,156 microns 2 mean cross-sectional area) fibres have A-bands of 4.1 microns, one-half I bands of 2.15 microns and Z lines less than or equal t...

journal_title：Journal of muscle research and cell motility

authors： Levine RJ,Davidheiser S,Kelly AM,Kensler RW,Leferovich J,Davies RE

更新日期：1989-02-01 00:00:00

abstract：:We found that the active tension of C2C12 myotubes that had been subjected to artificial exercise for ~10 days decreased rapidly after termination of the artificial exercise. When differentiated C2C12 myotubes were subjected to continuous 1 Hz artificial exercise for ~10 days, the active tension increased to ~4× compa...

journal_title：Journal of muscle research and cell motility

authors： Fujita H,Hirano M,Shimizu K,Nagamori E

更新日期：2010-12-01 00:00:00

abstract：:Skeletal muscle tissue is mechanosensitive, as it is able to sense mechanical impacts and to translate these into biochemical signals making the tissue adapt. Among its mechanosensitive nature, skeletal muscle tissue is the largest metabolic organ of the human body. Disturbances in skeletal muscle mechanosensing and m...

journal_title：Journal of muscle research and cell motility

authors： Pingel J,Suhr F

更新日期：2017-08-01 00:00:00

abstract：:The cellular function of the giant protein titin in striated muscle is a major focus of scientific attention. Particularly, its role in passive mechanics has been extensively investigated. In strong contrast, the structural details of this filament are very poorly understood. To date, only a handful of atomic models f...

journal_title：Journal of muscle research and cell motility

authors： Marino M,Svergun DI,Kreplak L,Konarev PV,Maco B,Labeit D,Mayans O

更新日期：2005-01-01 00:00:00

abstract：:Much has been written about the effects of aging on reproductive function, especially female fertility. Much less is known about how aging may affect the contractility of the smooth muscle within the uterus, the myometrium. The myometrium is active through a woman's entire life, not just during pregnancy. Here we will...

journal_title：Journal of muscle research and cell motility

authors： Arrowsmith S,Robinson H,Noble K,Wray S

更新日期：2012-08-01 00:00:00

abstract：:The aim of the study was to investigate sex-related differences in contractile properties, parameters of action potentials, and mechanisms of force regulation of motor units in the rat soleus muscle, which is a frequent experimental model in animal research. It was revealed that the mean mass of the muscle in males wa...

journal_title：Journal of muscle research and cell motility

authors： Drzymała-Celichowska H,Krutki P

更新日期：2015-06-01 00:00:00

abstract：:In this study the spontaneous activities of prescapular lymph nodes, which were isolated from calves, goats and sheep and mesenteric lymph nodes of guinea-pigs were recorded and analysed in the frequency domain. Stretch-evoked contractions of the mesenteric lymph nodes were also recorded and their frequency characteri...

journal_title：Journal of muscle research and cell motility

authors： Tümer A,Oztürk-Demir N,Basar-Eroğlu C,Noyan A

更新日期：1983-02-01 00:00:00

abstract：:Clenbuterol is a beta2-adrenoceptor agonist primarily used for treating bronchospasm and alleviating the symptoms of chronic obstructive pulmonary disease (COPD) in the horse. In other species (rats, mice, sheep, and cattle), chronic high doses of clenbuterol (typically in the milligram per kilogram body weight range)...

journal_title：Journal of muscle research and cell motility

authors： Plant DR,Kearns CF,McKeever KH,Lynch GS

更新日期：2003-01-01 00:00:00

abstract：:Monoclonal antibodies (mAb's) have been raised against proteins in preparations of Z-discs isolated from honeybee fibrillar flight muscle. These antibodies have identified four Z-disc antigens on immunoblots of honeybee fibrillar proteins. Antibody alpha binds to the 90-100 kD protein, alpha-actinin; mAb P interacts w...

journal_title：Journal of muscle research and cell motility

authors： Saide JD,Chin-Bow S,Hogan-Sheldon J,Busquets-Turner L

更新日期：1990-04-01 00:00:00