Abstract:
:The gene encoding E. coli nitroreductase (NTR) was expressed in the luminal cells of the mammary gland of transgenic mice using the ovine beta-lactoglobulin promoter. Treatment of NTR expressing animals with the prodrug CB1954 (5-aziridin-1-yl-2-4-dinitrobenzamide) resulted in a rapid and selective killing of this population of cells whereas the closely associated myoepithelial cells were unaffected. NTR-mediated inducible cell ablation offers a number of advantages over the use of HSV1-tk for the selective killing of cells in vivo.
journal_name
Gene Therjournal_title
Gene therapyauthors
Clark AJ,Iwobi M,Cui W,Crompton M,Harold G,Hobbs S,Kamalati T,Knox R,Neil C,Yull F,Gusterson Bdoi
10.1038/sj.gt.3300367subject
Has Abstractpub_date
1997-02-01 00:00:00pages
101-10issue
2eissn
0969-7128issn
1476-5462journal_volume
4pub_type
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