Abstract:
:Classical neurotransmitters are synthesized in the cytoplasm, so they require transport into secretory vesicles for regulated exocytotic release. Previous work has identified distinct vesicular transport activities for the different classical transmitters, and all depend on the H+-electrochemical gradient across the vesicle membrane but differ in the extent to which they rely on the chemical and electrical components of this gradient. Drugs that interfere with vesicular amine transport have implicated this activity in psychiatric disease. Selection for a cDNA encoding vesicular amine transport in the neurotoxin MPP+ also implicates the activity in Parkinson's disease. Molecular cloning of vesicular monoamine transporters shows sequence similarity to bacterial antibiotic resistance proteins, supporting a role for transport in detoxification and defining a novel mammalian gene family that now also includes a transporter for acetylcholine. Current work focuses on the mechanism of transport and the role that regulation of activity and its subcellular localization have in transmitter release, behavior, and neural degeneration.
journal_name
Annu Rev Neuroscijournal_title
Annual review of neuroscienceauthors
Liu Y,Edwards RHdoi
10.1146/annurev.neuro.20.1.125subject
Has Abstractpub_date
1997-01-01 00:00:00pages
125-56eissn
0147-006Xissn
1545-4126journal_volume
20pub_type
杂志文章,评审abstract::Human studies in the past three decades have provided us with an emerging understanding of how cortical and spinal networks collaborate to ensure the vast repertoire of human behaviors. Humans have direct cortical connections to spinal motoneurons, which bypass spinal interneurons and exert a direct (willful) muscle c...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-070815-013913
更新日期:2016-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.29.051605.112851
更新日期:2008-01-01 00:00:00
abstract::Prion diseases are transmissible neurodegenerative conditions that include Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) and scrapie in animals. Prions appear to be composed principally or entirely of abnormal isoforms of a host-encoded glycoprotein, prion protein. Prion propagat...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.24.1.519
更新日期:2001-01-01 00:00:00
abstract::The generation of distinct classes of neurons at defined positions within the developing vertebrate nervous system depends on inductive signals provided by local cell groups that act as organizing centers. Genetic and embryological studies have begun to elucidate the processes that control the pattern and identity of ...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.28.061604.135637
更新日期:2005-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-080317-061948
更新日期:2018-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.ne.12.030189.000435
更新日期:1989-01-01 00:00:00
abstract::Scientists have been fascinated by the human brain for centuries, yet knowledge of the cellular and molecular events that build the human brain during embryogenesis and of how abnormalities in this process lead to neurological disease remains very superficial. In particular, the lack of experimental models for a proce...
journal_title:Annual review of neuroscience
pub_type: 杂志文章
doi:10.1146/annurev-neuro-070918-050154
更新日期:2020-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.29.051605.112839
更新日期:2006-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.051508.135335
更新日期:2009-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-112210-112917
更新日期:2011-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-071714-033835
更新日期:2015-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.25.112701.142822
更新日期:2002-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.24.1.1121
更新日期:2001-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.ne.08.030185.002243
更新日期:1985-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.21.1.25
更新日期:1998-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.24.1.203
更新日期:2001-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.23.1.417
更新日期:2000-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-070918-050414
更新日期:2019-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,meta分析
doi:10.1146/annurev-neuro-062012-170320
更新日期:2014-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.26.041002.131421
更新日期:2003-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.28.061604.135718
更新日期:2005-01-01 00:00:00
abstract::Mutations in over 70 genes now define biological pathways leading to epilepsy, an episodic dysrhythmia of the cerebral cortex marked by abnormal network synchronization. Some of the inherited errors destabilize neuronal signaling by inflicting primary disorders of membrane excitability and synaptic transmission, where...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.26.010302.081210
更新日期:2003-01-01 00:00:00
abstract::The Wnt signaling pathway regulates multiple events in development and disease in both vertebrates and invertebrates. Recently, the noncanonical Wnt signaling cascades, those that do not signal through beta-catenin, have gained prominence for their role in the regulation of cellular polarity. It is not surprising that...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.29.051605.112933
更新日期:2006-01-01 00:00:00
abstract::Muscarinic signaling affects attention, action selection, learning, and memory through multiple signaling cascades, which act at different timescales and which alter ion channels in cell type-specific manners. The effects of muscarinic signaling differ between cortical layers and between brain areas. Muscarinic signal...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-062012-170433
更新日期:2013-07-08 00:00:00
abstract::The primate retina is an exciting focus in neuroscience, where recent data from molecular genetics, adaptive optics, anatomy, and physiology, together with measures of human visual performance, are converging to provide new insights into the retinal origins of color vision. Trichromatic color vision begins when the im...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev.neuro.23.1.743
更新日期:2000-01-01 00:00:00
abstract::Maturation of neuronal circuits requires selective elimination of synaptic connections. Although neuron-intrinsic mechanisms are important in this process, it is increasingly recognized that glial cells also play a critical role. Without proper functioning of these cells, the number, morphology, and function of synapt...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-070918-050306
更新日期:2019-07-08 00:00:00
abstract::The tragedy of epilepsy emerges from the combination of its high prevalence, impact upon sufferers and their families, and unpredictability. Childhood epilepsies are frequently severe, presenting in infancy with pharmaco-resistant seizures; are often accompanied by debilitating neuropsychiatric and systemic comorbidit...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-072116-031250
更新日期:2017-07-25 00:00:00
abstract::Understanding how sensory and motor processes are temporally integrated to control behavior in the hundredths of milliseconds-to-minutes range is a fascinating problem given that the basic electrophysiological properties of neurons operate on a millisecond timescale. Single-unit recording studies in monkeys have ident...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-062012-170349
更新日期:2013-07-08 00:00:00
abstract::Rhythmicity is a universal timing mechanism in the brain, and the rhythmogenic mechanisms are generally dynamic. This is illustrated for the neuronal control of breathing, a behavior that occurs as a one-, two-, or three-phase rhythm. Each breath is assembled stochastically, and increasing evidence suggests that each ...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
doi:10.1146/annurev-neuro-080317-061756
更新日期:2018-07-08 00:00:00