The role of vesicular transport proteins in synaptic transmission and neural degeneration.

Abstract:

:Classical neurotransmitters are synthesized in the cytoplasm, so they require transport into secretory vesicles for regulated exocytotic release. Previous work has identified distinct vesicular transport activities for the different classical transmitters, and all depend on the H+-electrochemical gradient across the vesicle membrane but differ in the extent to which they rely on the chemical and electrical components of this gradient. Drugs that interfere with vesicular amine transport have implicated this activity in psychiatric disease. Selection for a cDNA encoding vesicular amine transport in the neurotoxin MPP+ also implicates the activity in Parkinson's disease. Molecular cloning of vesicular monoamine transporters shows sequence similarity to bacterial antibiotic resistance proteins, supporting a role for transport in detoxification and defining a novel mammalian gene family that now also includes a transporter for acetylcholine. Current work focuses on the mechanism of transport and the role that regulation of activity and its subcellular localization have in transmitter release, behavior, and neural degeneration.

journal_name

Annu Rev Neurosci

authors

Liu Y,Edwards RH

doi

10.1146/annurev.neuro.20.1.125

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

125-56

eissn

0147-006X

issn

1545-4126

journal_volume

20

pub_type

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