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Stages in the development of radiation-induced thymic lymphomas in C57 BL/Ka mice: preleukemic cells become progressively resistant to the tumor preventing effects of a bone marrow graft.

Abstract：

:Fractionated whole body irradiation induces thymic lymphomas in C57 BL/Ka mice after 6-12 months. A graft of normal congenic bone marrow cells immediately after the last irradiation prevents the development of lymphomas by inducing the disappearance of preleukemic cells. When such a graft is performed one month later, it does not inhibit the emergence of tumors. It could be because, one month after irradiation, preleukemic cells become insensitive to the effects of the grafted bone marrow on their leukemogenic potential. To check this hypothesis, we have investigated the capacity of grafted bone marrow cells to prevent the development of lymphomas in mice inoculated with radiation-induced preleukemic cells collected at several time intervals after the completion of the radiation regimen. It was found that the bone marrow graft reduced the incidence of thymic lymphoma at day 2 (10 vs. 43%; p < 0.01) and 10 (39 vs. 86%; p < 0.01) but not at day 15 (64 vs. 80%; NS) or 30 (93 vs. 82%; NS). The inefficacy of the marrow graft was not associated with proliferation of the inoculate in the recipient thymus nor with inhibition by preleukemic cells of thymic repopulation by bone marrow precursors. The data provide evidence that preleukemic cells undergo intrinsic changes which are reflected by the acquisition of resistance to bone marrow grafts.

journal_name

Exp Hematol

journal_title

Experimental hematology

authors

Humblet C,Greimers R,Boniver J,Defrense MP

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

109-13

issue

2

eissn

0301-472X

issn

1873-2399

journal_volume

25

pub_type

杂志文章

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