European Concerted Action on Anticoagulation (ECAA)-the multicentre calibration of rabbit and human ECAA reference thromboplastins. Steering Committee.

Abstract:

:Two candidate ECAA reference preparations have been calibrated in a multicentre exercise at 14 representative national laboratories to provide reference thromboplastin for a large field study in 16 European countries. Two preparations were required because of the established differences in ISI arising from the two main routes of calibration via rabbit and human IRP. To be comparable with working reagents in everyday use a human plain recombinant reagent of low ISI and a rabbit plain preparation of moderately high ISI were selected. A precise calibration of the two candidate preparations has been achieved with the manual PT technique and an ISI of 0.95 (SE 0.0078) for the human reagent and 1.67 (SE 0.0322) for the rabbit reagent.

journal_name

Thromb Haemost

authors

Poller L,Barrowcliffe TW,van den Besselaar AM,Jespersen J,Tripodi A,Houghton D

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

977-82

issue

6

eissn

0340-6245

issn

2567-689X

journal_volume

76

pub_type

杂志文章,多中心研究
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    authors: Koike C,Hayakawa Y,Niiya K,Sakuragawa N,Sasaki H

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  • Identification of dense granule specific membrane proteins in bovine platelets that are absent in the Chediak-Higashi syndrome.

    abstract::Platelets from cattle with the Chediak-Higashi syndrome (CHS) have a platelet dense granule deficiency. One hypothesis for the platelet dense granule deficiency is that the granule is simply not formed in CHS megakaryocytes (MK). Alternative hypotheses include that the granule is assembled in CHS MK but a functional a...

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    doi:

    authors: Meyers K,Seachord C

    更新日期:1990-10-22 00:00:00

  • Von Willebrand's disease caused by compound heterozygosity for a substitution mutation (T1156M) in the D3 domain of the von Willebrand factor and a stop mutation (Q2470X).

    abstract::Hereditary defects of the von Willebrand factor (VWF) gene cause von Willebrand's disease (VWD) which shows great variability dependent on the nature and location of the mutation. We here describe the characteristics of a substitution of methionine for threonine 1156 in the D3 domain of the VWF, i.e. the domain involv...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Lethagen S,Isaksson C,Schaedel C,Holmberg L

    更新日期:2002-09-01 00:00:00

  • High levels of adhesion molecules are associated with impaired endothelium-dependent vasodilation in patients with peripheral arterial disease.

    abstract::Soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cellular adhesion molecule-1 (sVCAM-1) were measured alongside flow-mediated vasodilation (FMD) in 34 patients with intermittent claudication and 14 control subjects. Patients with plasma sICAM-1 >253 ng/mL (median value) showed lower FMD than those with...

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    pub_type: 杂志文章

    doi:

    authors: Brevetti G,Martone VD,de Cristofaro T,Corrado S,Silvestro A,Di Donato AM,Bucur R,Scopacasa F

    更新日期:2001-01-01 00:00:00

  • Animal models of vulnerable plaque. Clinical context and current status.

    abstract::There is increasing recognition of the importance of vulnerable plaque and acute plaque rupture leading to thrombosis, in the pathogenesis of acute coronary syndromes. This is fueling a number of developments, including novel imaging modalities and potential plaque stabilization therapies. However, to date, no animal ...

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    pub_type: 杂志文章,评审

    doi:10.1160/TH03-06-0374

    authors: Lowe HC,Jang IK,Khachigian LM

    更新日期:2003-11-01 00:00:00

  • Changes in von Willebrand factor-cleaving protease (ADAMTS-13) in patients with aortic stenosis undergoing valve replacement or balloon valvuloplasty.

    abstract::It was the objective of this study to determine whether reduced cleavage of von Willebrand factor (VWF) multimers following aortic valve replacement (AVR) is a consequence of reduced shear stress or postoperative changes in VWF cleavage protease (ADAMTS-13) activity. Aortic stenosis (AS) may be complicated by acquired...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH11-12-0803

    authors: Bander J,Elmariah S,Aledort LM,Dlott J,Stelzer P,Halperin JL,Kini AS,Sharma SK

    更新日期:2012-07-01 00:00:00

  • Effect of calcium and synthetic peptides on fibrin polymerization.

    abstract::Human fibrinogen was subjected to limited proteolytic attack by thrombin, batroxobin or Agkistrodon contortrix thrombin-like enzyme, yielding desAB-, desA- or desB-fibrin monomers, respectively. Turbidity curves demonstrated that, with all three enzymes, the polymerization process was strongly accelerated by increasin...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Furlan M,Rupp C,Beck EA,Svendsen L

    更新日期:1982-04-30 00:00:00

  • Pneumococcal association to platelets is mediated by soluble fibrin and supported by thrombospondin-1.

    abstract::Platelets and coagulation are involved in bacterial colonisation of the host. Streptocococcus pneumoniae (pneumococcus) are important etiologic agents of respiratory tract infections in humans. The formation of pneumococci-platelet associations may facilitate haematogenous dissemination of pneumococci by providing an ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH09-01-0049

    authors: Niemann S,Kehrel BE,Heilmann C,Rennemeier C,Peters G,Hammerschmidt S

    更新日期:2009-10-01 00:00:00

  • Lysophosphatidic acid activates nuclear factor kappa B and induces proinflammatory gene expression in endothelial cells.

    abstract::The cellular phospholipid, lysophosphatidic acid (LPA), released by activated platelets and fibroblasts or, at high levels, from ovarian and cervical carcinomas is a powerful serum mitogen that may modulate several signaling pathways in endothelial cells (EC). Hence, LPA could function in a paracrine manner during EC-...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Palmetshofer A,Robson SC,Nehls V

    更新日期:1999-11-01 00:00:00

  • Intra-operative activation of coagulation--a stimulus to thrombosis mediated by vasopressin?

    abstract::Vasopressin infusions in normal volunteers that produce concentrations in plasma comparable to those seen during stress, cause an increase in plasma factor VIII and shortening of the euglobulin clot lysis time (ECLT). We have investigated the relationship between endogenous vasopressin (aVP) release and haemostatic fu...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Grant PJ,Tate GM,Davies JA,Williams NS,Prentice CR

    更新日期:1986-02-28 00:00:00

  • Effect of adjunctive dipyridamole to DAPT on platelet function profiles in stented patients with high platelet reactivity. The result of the ACCEL-DIP Study.

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    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,随机对照试验

    doi:10.1160/TH14-01-0040

    authors: Park Y,Jeong YH,Tantry US,Ahn JH,Kim KH,Koh JS,Park JR,Hwang SJ,Kwak CH,Hwang JY,Gurbel PA

    更新日期:2014-12-01 00:00:00

  • B cell dysfunction in haemophilia in the absence and presence of HIV-1 infection.

    abstract::56 haemophiliacs selected on the basis of HIV-1 antibody status, liver disease grade and mean annual dose of clotting factor concentrate used were studied. Spontaneous and stimulated IgG and IgM production in vitro were measured. HIV-1 infection was associated with increased spontaneous immunoglobulin production and a...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Madhok R,Gracie JA,Forbes CD,Lowe GD

    更新日期:1991-01-23 00:00:00

  • Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia.

    abstract::Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin α2β1, or to defects in downstream signalling events by comparison to platelet activation by C-type...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0038-1646924

    authors: Hardy AT,Palma-Barqueros V,Watson SK,Malcor JD,Eble JA,Gardiner EE,Blanco JE,Guijarro-Campillo R,Delgado JL,Lozano ML,Teruel-Montoya R,Vicente V,Watson SP,Rivera J,Ferrer-Marín F

    更新日期:2018-06-01 00:00:00

  • Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation.

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    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH12-03-0202

    authors: Berger JS,Becker RC,Kuhn C,Helms MJ,Ortel TL,Williams R

    更新日期:2013-01-01 00:00:00

  • Elevated D-dimer level is an independent risk factor for cardiovascular death in out-patients with symptoms compatible with heart failure.

    abstract::D-dimer, a marker of fibrin turnover, exhibits many interesting properties as a biological marker of thrombosis. Some of the properties of D-dimer might also be used to provide additional information about patients with heart failure. In this study, we evaluate the prognostic information acquired from D-dimer concerni...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH04-05-0278

    authors: Alehagen U,Dahlström U,Lindahl TL

    更新日期:2004-12-01 00:00:00

  • The action of ticlopidine on human platelets. Studies on aggregation, secretion, calcium mobilization and membrane glycoproteins.

    abstract::The effects on platelet function of a 5-day course of Ticlopidine (Tcl) have been studied in two groups of volunteers receiving different dosage schedules. Tcl had a relatively greater inhibitory effect on aggregation induced by ADP than by other agonists, and a greater effect, in contrast to that of an ADP receptor a...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Hardisty RM,Powling MJ,Nokes TJ

    更新日期:1990-08-13 00:00:00

  • Extent of differentiated gene expression in the human endothelium-derived EA.hy926 cell line.

    abstract::Vascular endothelial cells perform many differentiated functions in processes such as angiogenesis, hemostasis, and inflammation. The number of recognized differentiated functions has increased rapidly in recent years, but there may be many more still unrecognized. The purpose of this study is to estimate the fraction...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Rieber AJ,Marr HS,Comer MB,Edgell CJ

    更新日期:1993-05-03 00:00:00

  • Cultured human mesangial cells produce both type 1 and type 2 plasminogen activator inhibitors.

    abstract::Cultured human mesangial cells (HMC) derived from normal kidneys have been shown to synthesize tissue-type plasminogen activator (t-PA) and excess amounts of PA inhibitor type 1 (PAI-1). Conflicting results have been obtained concerning the production of urokinase-type PA (u-PA) and efforts to show PA inhibitor 2 (PAI...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Colucci M,Gesualdo L,Montemurro P,Cavallo LG,Conese M,Mascolo E,Ranieri E,Di Paolo S,Schena FP,Semeraro N

    更新日期:1995-12-01 00:00:00

  • Regulation of urokinase receptor function and pericellular proteolysis by the integrin alpha(5)beta(1).

    abstract::Interactions between the uPA receptor (uPAR) and various integrins, including alpha(5)beta(1), are known to modulate integrin-dependent cell adhesion, and we have shown that the integrin-associated tetraspanin protein CD82 down-regulates uPAR-dependent plasminogen activation by affecting alpha(5)beta(1) cellular local...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Bass R,Ellis V

    更新日期:2009-05-01 00:00:00

  • Anticoagulation in patients with atrial fibrillation undergoing coronary stent implantation.

    abstract::In patients with atrial fibrillation (AF) undergoing coronary stent implantation, the optimal antithrombotic strategy is unclear. We evaluated whether use of oral anticoagulation (OAC) was associated with any benefit in morbidity or mortality in patients with AF, high risk of thromboembolism (TE) (CHA2DS2-VASC score ≥...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH13-04-0351

    authors: Bernard A,Fauchier L,Pellegrin C,Clementy N,Saint Etienne C,Banerjee A,Naudin D,Angoulvant D

    更新日期:2013-09-01 00:00:00

  • Platelets release their lysosomal content in vivo in humans upon activation.

    abstract::Platelets contain, besides alpha- and delta-granules, lysosomes which store glycohydrolases able to degrade glycoproteins, glycolipids and glycosaminoglycans. While several studies have shown that alpha- and delta-granule secretion takes place "in vivo" in humans upon platelet activation, no data are available on the ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Ciferri S,Emiliani C,Guglielmini G,Orlacchio A,Nenci GG,Gresele P

    更新日期:2000-01-01 00:00:00

  • Factor VIII: C and factor VIII R: Ag in Argentine hemorrhagic fever.

    abstract::Factor VIII procoagulant activity (F VIII:C) and factor VIII related antigen (F VIII R: Ag) were investigated in 35 patients with Argentine hemorrhagic fever. Since the results obtained in the three clinical forms of the disease were not significantly different, they were tabulated altogether. F VIII:C was low in earl...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Molinas FC,Maiztegui JI

    更新日期:1981-08-28 00:00:00

  • A prospective, randomized trial of prednisone and cyclophosphamide in the treatment of patients with factor VIII autoantibodies.

    abstract::Thirty-one non-hemophilic patients with acquired antibodies to factor VIII were entered into a prospective, randomized, multi-institutional trial to determine the safety and efficacy of prednisone (P), cyclophosphamide (C), or the combination in the treatment of this disorder. Patients were eligible if they had antibo...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Green D,Rademaker AW,Briët E

    更新日期:1993-11-15 00:00:00

  • Pathophysiology of platelet thrombin receptors.

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    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Jamieson GA

    更新日期:1997-07-01 00:00:00

  • The A6936G polymorphism of the endothelial protein C receptor gene is associated with the risk of unexplained foetal loss in Mediterranean European couples.

    abstract::The endothelial protein C receptor (EPCR) is expressed by trophoblast cells. Mid-gestation pregnancy loss is described in animals with a haemochorial placenta lacking EPCR. The A6936G allele of the EPCR gene (PROCR) may be associated with lower EPCR densities on trophoblasts, but data are lacking for its effect on the...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH-09-04-0224

    authors: Cochery-Nouvellon E,Chauleur C,Demattei C,Mercier E,Fabbro-Peray P,Marès P,Mismetti P,Lissalde-Lavigne G,Gris JC

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  • Aggregation of washed platelets from non-anticoagulated human blood is not reversible.

    abstract::Most of the knowledge acquired on platelet function and biochemistry has been obtained from platelets prepared from blood anticoagulated with sodium citrate. Using washed platelets from human blood (PNB) to which no anticoagulants were added, we report on responses not observed with platelets prepared from citrate-ant...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Bowry SK,Müller-Berghaus G

    更新日期:1986-10-21 00:00:00

  • A cross sectional study of antiphospholipid-protein antibodies in patients with venous thromboembolism.

    abstract:OBJECTIVE:To look for an association between venous thromboembolism (VTE) and antiphospholipid antibodies (aPL) in patients without Systemic Lupus Erythematosus (SLE) when implementing, beside conventional assays, new tests for aPL screening directed towards purified proteic targets. METHODS:We conducted a cross-secti...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Pasquier E,Amiral J,de Saint Martin L,Mottier D

    更新日期:2001-08-01 00:00:00

  • Increase in plasma concentration of plasminogen activator inhibitor, fibrinogen, von Willebrand factor, factor VIII:C and in erythrocyte sedimentation rate with age.

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    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Aillaud MF,Pignol F,Alessi MC,Harle JR,Escande M,Mongin M,Juhan-Vague I

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  • Platelets adhere to sulfatides by von Willebrand factor dependent and independent mechanisms.

    abstract::Unstimulated human platelets from normal volunteers adhere to sulfatides (galactosylceramide-I3-sulfate) as single cells but do not adhere appreciably to other lipids including gangliosides, neutral glycolipids, phospholipids or cholesterol-3-SO4. Platelet adhesion to sulfatide is saturable and dose-dependent, reaches...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Data RE,Williams SB,Roberts DD,Gralnick HR

    更新日期:1991-05-06 00:00:00

  • Chronological expression of PAR isoforms in acute liver injury and its amelioration by PAR2 blockade in a rat model of sepsis.

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    pub_type: 杂志文章

    doi:

    authors: Jesmin S,Gando S,Zaedi S,Sakuraya F

    更新日期:2006-12-01 00:00:00