Cortico-thalamic interplay and the security of operation of neural assemblies and temporal chains in the cerebral cortex.

Abstract:

:Much evidence suggests that the mammalian thalamus is not merely a set of nuclei relaying signals to the cerebral cortex, but is engaged in two-way interplay with it. Three important features constrain ideas about the nature of this interplay: (i) thalamic projection neurones lack local axon collaterals; (ii) most corticothalamic projections have very long axonal conduction time; (iii) in the waking state the membrane potential of thalamic projections cells appears to be poised just beneath threshold for firing. It is proposed that corticothalamo-cortical pathways represent connections between different cortical loci which have higher security than the direct cortico-cortical route. Thus each thalamo-cortical projection neurone can have a singular and pivotal role in the activation of one or more cortical neural assemblies. The long delays of cortico-thalamic conduction suggest that the cortico-thalamo-cortical loop also plays a crucial role in the operation of time-structured neural assemblies ('synfire chains'; Abeles), by providing a high-security link from one active node of the chain to nodes activated at a later time in the sequence. It is predicted that, in the waking animal, thalamic projection cells should have a response selectivity to complex percepts and concepts, conferred on them by the cortical assemblies in whose activation they participate.

journal_name

Biol Cybern

journal_title

Biological cybernetics

authors

Miller R

doi

10.1007/s004220050293

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

263-75

issue

3

eissn

0340-1200

issn

1432-0770

journal_volume

75

pub_type

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